Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- Kitap BölümüYalnız künye2022Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis
Farooqi, Ammad Ahmad; Ozbey, Ulku; Pimentel, Tatiana Colombo; Attar, Rukset
The magical little fruits have started to gain attention because of their cancer chemopreventive roles against different cancers. More recently, cancer inhibitory properties of blueberry extracts and isolated bioactive constituents have been described that provide new mechanistic insights. However, there are visible knowledge gaps in our understanding about metastasis inhibitory role of blueberries in xenografted mice. Despite mainstream popularization of cancer chemopreventive role of blueberries, many questions remain about their precise role in the regulation of deregulated oncogenic cascades in metastasis. It will be really exciting to consider how new scientific breakthroughs in future might propel the science of nutrigenomics to a more sophisticated level of inquiry.
AtıfScopus2OpenAlex1
İncele - MakaleAçık Erişim2022Scopus SJRQ1Cadmium exposure in population: alcoholic beverage consumption and health risk assessment
Kaplan Ince, Olcay; Ince, Muharrem; Onal, Ali
Risk assessment of cadmium (Cd) for human health play a key role because of toxic effect. Researchers are undergoing constant development for modelling approaches to make a risk assessment. It was carried out a central composite design combining with response surface modeling to optimize and modeling of Cd2+ ions in this study. Also, this study was performed to provide information about possible risk associated with alcoholic beverage consumption. Some independent process parameters including contact time and pH were chosen for optimization. Under optimal parameters, 142.9 mg g−1 was determined as Cd2+ ions removal effectiveness. Significance independent parameters and their interactions were checked using analysis of variance. These results were verified by correlation coefficients (R2 = 0.9967) of the statistical prediction. Estimated daily intake (EDI) and target hazard quotients (THQ) were calculated, to assess health risk. The Cd2+ ions EDI values (µg/day/person) were less than the recommended dietary allowance values and also, its THQ value was less than 1, also. When the obtained results compared with the levels set by regulatory authorities, the studied alcoholic beverages consumption do not pose a toxicological risk. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus3OpenAlex3
İncele - MakaleYalnız künye2022Scopus SJRQ3Characterization of the antioxidant activity, total phenolic content, enzyme inhibition, and anticancer properties of Achillea millefolium L. (yarrow)
Karaaslan Ayhan, Nagihan; Karaaslan Tunc, Merve Goksin; Noma, Samir Abbas Ali; Kurucay, Ali; Ates, Burhan
The antioxidant activity, total phenolic content, enzyme inhibition, anticancer properties of Achillea millefolium L. (yarrow), which is generally consumed by humans as herbal tea, were investigated. Yarrow extracts were prepared with different extraction techniques and solvents and the optimum conditions were determined. When the antioxidant activity and total phenolic content results were evaluated, the best yield was obtained with ultrasound-assisted extraction for all solvents. Moreover, the yields from highest to lowest were methanol, water, and acetonitrile. The enzyme inhibition and anticancer of Achillea millefolium L. extracts using methanol were evaluated. The IC50 values for the inhibition of xanthine oxidase and acetylcholinesterase were 4.974 ± 0.54 and 21.891 ± 1.118 µg/mL, respectively. The extract concentration was determined to be 23.85 μg/mL for 50% reduction in growth inhibitory activity cell viability (IC50) against breast cancer (MCF-7).
AtıfScopus7OpenAlex9İncele - MakaleAçık Erişim2022Scopus SJRQ3Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate
Akkoyun, H. Turan; Aydın, Sevinç; Akkoyun, Mahire Bayramoglu; Bengü, Aydın Şükrü; Ekin, Suat; Erdem, Sinem Aslan
Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3 ) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 ± 0.53-11.71 ± 2.55 and 33.71 ± 2.12-37.11 ± 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29-9.96 ± 1.18 and 14.72 ± 3.66-22.13 ± 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts.
AtıfOpenAlex1İncele - Kitap BölümüYalnız künye2022X-Ray Computed Tomography and Magnetic Resonance Imaging Applications of Magnetic Nanoalloys and Nanocomposites
Aslan, Naim; Koç, Mümin Mehmet
Metallic nanoparticles were used in different medical and biological applications. Such applications can cover targeted drug delivery, biomarking, MRI imaging, CT imaging, magnetic hyperthermia, etc. Metallic nanoparticles show outstanding properties with high electron affinity and good electrical, electronic, and optoelectronic properties with possible magnetic characteristics. In this regard, magnetic nanoparticles and magnetic nanoalloys are found to be a suitable candidate to be used in imaging applications. In this chapter, concepts of X-ray computed tomography imaging and magnetic resonance imaging are briefly discussed. Magnetic nanoparticles, nanoalloys, and nanocomposites used in imaging, diagnostics, and theranostic applications were illustrated.
AtıfScopus2OpenAlex1İncele - MakaleAçık Erişim2022Scopus SJRQ2The effect of COVID-19 restrictions on sleep quality of university students and variables predicting sleep quality
Bulut, Arzu; Sengul, Halil; Uslu, Yeter Demir; Bas, Kazim; Tosun, Nurperihan
BACKGROUND/AIM: The COVID-19 pandemic has created a long period of stress for people worldwide and has significantly affected sleep duration. The pandemic revealed new stress factors that are likely to affect sleep. Uncertainty is a factor that leads to anxiety and depression, which affects sleep. It should also be noted that reductions in sleep quality rather than sleep duration are associated with negative consequences on mental health. This study aims to investigate online that how this situation affected university students. MATERIALS AND METHODS: This research, with a descriptive study design, was conducted in Turkey between June 01, 2021 and July 30, 2021. The sample included 604 people who accepted voluntary participation, chosen by the random selection method. In the study, sociodemographic information form, Pittsburgh sleep quality index (PSQI), morningness-eveningness questionnaire scale (MEQ Scale), Beck depression inventory (BDI), and Beck anxiety inventory (BAI) were used as data collection tools. Pearson correlation analysis was utilized to examine the relationship between the scales. Multiple regression analysis was performed to investigate the role of morningness-eveningness, anxiety, depression, and insomnia severity on sleep quality. RESULTS: Sleep quality was negatively correlated with morningness-eveningness scores (r = -0.32, P < 0.01), and positively and significantly related with anxiety (r = 0.43, P < 0.01), depression (r = 0.40, P < 0.01) and insomnia severity (r = 0.55, P < 0.01). According to regression coefficients, while anxiety (β = 0.041, P < 0.001) and insomnia severity scores (β = 0.226, P < 0.001) positively predicted sleep quality, depression did not predict it significantly (β = 0.009, P > 0.05). A significant difference was found in sleep quality according to morning, evening, and intermediate types (F = 27.401, P < 0.001). CONCLUSION: Events related to the COVID-19 pandemic are associated with reduced sleep quality in connection with increasing negative moods. Considering the importance of sleep for a healthy life, efforts should be made to raise awareness about this issue and to provide psychological help to affected individuals.
AtıfScopus8WoS7OpenAlex10İncele - Derleme MakaleAçık Erişim2022Scopus SJRQ1Dietary exposure to acrylamide: A critical appraisal on the conversion of disregarded intermediates into acrylamide and possible reactions during digestion
Aktağ, Işıl Gürsul; Hamzalıoğlu, Aytül; Kocadağlı, Tolgahan; Gökmen, Vural
The amount of acrylamide in asparagine rich thermally processed foods has been broadly monitored over the past two decades. Acrylamide exposure can be estimated by using the concentration of acrylamide found in foods and alternatively, biomarkers of exposure are correlated. A better estimation of dietary acrylamide exposure is crucial for a proper food safety assessment, regulations, and public health research. This review addresses the importance of the presence of neglected Maillard reaction intermediates found in foods, that may convert into acrylamide during digestion and the fate of acrylamide in the gastrointestinal tract as a reactive compound. Therefore, it is questioned in this review whether acrylamide concentration in ingested foods is directly correlated with the dietary exposure to acrylamide.
AtıfScopus32WoS26OpenAlex31İncele - MakaleAçık Erişim2021Doğum sonu depresyonun kişilik özellikleri ile ilişkisi
Okyay, Esra Karataş; Ucar, Tuba; Gökbulut, Nilay; Sunay, Zeliha
Bu araştırma, doğum sonu depresyonun kişilik özellikleri ile ilişkisini belirlemek amacıyla yapıldı. Tanımlayıcı ve ilişki arayıcı tipte olan araştırmanın örneklemini, Haziran-Eylül 2018 tarihleri arasında Malatya’da bir kamu hastanesinin kadın doğum polikliniklerine başvuran, doğum sonu 0-3 ay arasında olan 381 kadın oluşturdu. Veriler yüz yüze görüşme yöntemi kullanılarak; Kişisel Bilgi Formu, Edinburgh Postpartum Depresyon Skalası (EPDS) ve On-Maddeli Kişilik Ölçeği (OMKÖ) ile toplandı. Araştırmada kadınların EPDS toplam puan ortalaması 5,66±4,72 olup, kadınların %14,2’sinde (n=54) depresif semptom varlığı olduğu belirlendi. Ayrıca, doğum sonu depresyon ile OMKÖ alt boyutları olan dışa dönüklük, sorumluluk, duygusal dengelilik ve yumuşak başlılık arasında negatif yönde anlamlı ilişki bulundu (sırasıyla r=-0,142, r=-0,242, r=-0,251, r=-0,223; p<0,05). Çoklu doğrusal regresyon modeli sorumluluk, duygusal dengelilik ve yumuşak başlılık gibi kişilik özelliklerinin doğum sonu depresyonun önemli belirleyicileri olduğunu göstermiştir (sırasıyla β=-0,286, β=-0,316, β=-0,267; p<0,05). Elde edilen bulgulara göre; sorumluluk özelliği düşük, duygusal dengesiz ve yumuşakbaşlı olmayan kişilik özelliklerine sahip kadınların doğum sonu depresyon açısından riskli gruplar olduğu söylenebilir.
AtıfOpenAlex7TR Dizin4
İncele - MakaleAçık Erişim2021Investigation of Chrysin Effects on Lead Asetat-Induced Liver Damage in Rats
Benzer, Fulya; Kandemir, Fatih Mehmet; Yildirim, Serkan; Coşkun, Pınar; Küçükler, Sefa
This study was conducted to investigate the effects of chrysin (CH) on lead acetate (PbA) inducing liver injury. In this study, 35 male Sprague Dawley rats were divided into 5 groups as 7 rats in each group. Group 1 (Control): Saline was given orally. Group 2 (CH group): CH (50 mg kg-1 weight day-1 ) were orally given rats for 7 days. Group 3 (PbA group): PbA (30 mg kg-1 ) was orally given to rats at 30 mg kg-1 PbA for 7 days. Group 4 (PbA +CH 25 group): 25 mg/kg CH was orally given to rats for 7 days. In addition, 30 mg kg-1 PbA was given orally to rats for 7 days after 30 minutes of the application of the CH. Group 5 (PbA+CH 50 group): 50 mg kg-1 CH was orally given to rats for 7 days. Furthermore, 30 mg kg-1 PbA was given orally to rats for 7 days after 30 minutes of the application of the CH. The rats were euthanized under mild sevoflurane anesthesia and tissue and blood samples were taken 24 hours after the last application (8th day). AST, ALT and ALP in serum, MDA, GSH and NO levels and SOD, CAT, GPx and arginase enzyme activities in liver tissue were measured. Serum ALT, AST and ALP levels increased in the PbA group when compared with the control, and this increase was partially corrected with CH. Liver MDA and NO levels increased in the PbA administered groups while antioxidant enzyme activities and GSH levels decreased. Although, CH administration decreased the increased MDA and NO levels, it increased the decreased antioxidant enzyme activities and GSH levels. Histologically, it was determined that CH decreased the necrosis, hydropic degenerations and mononuclear cell infiltrations seen in the livers of rats treated with PbA. As a result, CH is effective in the reducing PbA damages in the liver.
AtıfOpenAlex3TR Dizin3İncele - MakaleAçık Erişim2021TOPSIS-Sort temelli nicel bir mesleki risk değerlendirme metodolojisi ve alüminyum ekstrüzyon endüstrisinde uygulanması
Gul, Muhammet
Alüminyum ekstrüzyon üretimini de kapsayan metal ürünleri sektörü, iş sağlığı ve güvenliği (İSG) açısından yüksek risk taşıyan sektörlerden biridir. Bu durum ve sektördeki iş kazalarının artış eğilimi göz önüne alındığında, iş güvenliğinin artırılması ihtiyacı ortaya çıkmaktadır. Bu nedenle, bu çalışma, alüminyum ekstrüzyon endüstrisindeki riskleri yönetmek için kümeleme temelli bir TOPSIS yaklaşımı (TOPSIS-Sort) ile nicel bir mesleki risk değerlendirmesi önermektedir. Risk değerlendirmesinde önemli bir süreç olan elde edilen risk değerine göre risk sınıflandırmasının gerekliliği nedeniyle sıralamaya dayalı bir metodoloji önerilmiştir. Metodolojinin uygulanabilirliği, 28 potansiyel tehlikenin üç risk parametresi (olasılık, ciddiyet ve sıklık) altında değerlendirilmesiyle gösterilmiştir. Değerlendirilen tehlikeler beş risk kümesine (Çok yüksek risk, Yüksek risk, Önemli risk, Olası risk ve Risk) bölünmüş ve risklerin azaltılmasını sağlayacak kontrol önlemleri belirlenmiştir. Çalışmanın sonuçları, Çok yüksek risk kümesine bir tehlikenin, Yüksek risk kümesine 3, Önemli risk kümesine 23 ve Olası risk kümesine bir tehlike atandığını göstermektedir.
AtıfOpenAlex16TR Dizin4İncele - MakaleAçık Erişim2021Nhibitory Property of Poly (AN-co-VP) Copolymer on Some Dermatophyte Fungiand Yeasts Causing Fungal Infections
Torgut, Gulben; Kirbag, Sevda; Sönmez, Pınar Erecevıt; Pıhtılı, Güzin
Antimicrobial susceptibility test for poly (AN-co-VP) copolymer, which we think could be an ideal drug in treatment interventions was evaluated with disk diffusion method and minimum inhibitor concentration. In the antimicrobial measurement data, it was determined that the poly (AN-co-VP) copolymer dissolved in pure water is a significant inhibitory property against the growth of yeast (on Candida spp. with 11.33±0.3 mm barrier area) and dermatophyte fungi (on Epidermophyton sp. and Trichophyton sp.with 12.33±0.3 mm barrier area) (p<0.001) and no inhibitory properties were observed in preventing the growth of all bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus megaterium). MIC limit values that prevent the growth of dermatophytes and yeasts supporting the disc diffusion method are 50-100 μL. This study is an alternative approach in order to limit the spread of superficial fungal infections they cause and eliminate these infections that tend to become chronic since this polymer extract has no inhibitory properties on bacteria but prevents the growth of yeast and dermatophytes.
AtıfOpenAlex1İncele - MakaleAçık Erişim2021Gadolinyumun Tatlı Su Omurgasızı Dreissena polymorpha Üzerindeki Biyokimyasal Etkileri
Serdar, Osman; Yildirim, Nuran Cikcikoglu; Yildirim, Numan; Tatar, Sule
Bu çalışma, metabolik ve oksidatif stres biyobelirteçlerinin analizi yoluyla, su kirliliğinin iyi bir biyoindikatörü olarak kabul edilen tatlı su omurgasızı Dreissena polymorpha üzerindeki Gadolinyum (Gd) toksisitesini değerlendirmeyi amaçlamaktadır. Öncelikle çalışmamızda Gd’nin D. polymorpha üzerindeki LC50 değeri belirlenmiştir. D. polymorpha, kontrollü koşullar altında 24 ve 96 saatlik bir süre boyunca üç letal olmayan Gd konsantrasyonuna (1/20, 1/10 ve 1/5 LC50 değerine) maruz bırakılmıştır. TBARS ve CYP1A1 seviyeleri ELISA kiti kullanılarak belirlenmiştir. CYP1A1 ve TBARS düzeylerinin tüm gruplarda 24. ve 96. saatte kontrol grubuna göre arttığı görülmüştür. Bu sonuçlar, Gd'nin tatlı su omurgasızları, D. polymorpha için bir risk olarak kabul edilebileceğini ve bu nedenle alıcı ortamlara deşarjının denetlenmesi gerektiğini göstermektedir.
AtıfOpenAlex8TR Dizin4İncele - MakaleAçık Erişim2021Bir Hemşirelik Bölümünde Öğrenim Gören Öğrencilerin Hemşirelik Bakım Davranışları Algısının Belirlenmesi
Şeker, Sevda Arslan; Gül, Şenay
Amaç: Bu araştırma, hemşirelik öğrencilerinin hemşirelik bakımına ilişkin algılarının ve bakımı etkileyen faktörlere ilişkin görüşlerinin incelenmesi amacıyla yapılmıştır. Gereç ve Yöntem: Tanımlayıcı nitelikteki bu araştırmanın örneklemini 2019-2020 eğitim-öğretim döneminde bir üniversitenin hemşirelik bölümünde öğrenim gören, araştırmaya katılmayı kabul eden 142 öğrenci oluşturmuştur. Araştırmanın verileri “Tanıtıcı Özellikler Formu” ve “Bakım Davranışları Ölçeği-30 (BDÖ-30)” kullanılarak toplanmıştır. Araştırmanın verileri tanımlayıcı istatistikler, Mann Whitney U ve Kruskal Wallis Analizi ile incelenmiştir. Bulgular: Araştırmaya katılan öğrencilerin yaş ortalaması 20.80±1.839 yıl, %56.3’ü kadın ve %59.9’u Anadolu lisesi mezunudur. Öğrencilerin BDÖ-30 puan ortalaması 150.79±21.81’dir. Öğrencilerin cinsiyet ve öğrenim gördükleri sınıflarına göre BDÖ-30 puan ortalamaları arasında istatistiksel olarak anlamlı farklılık olduğu belirlenmiştir. Sonuç: Araştırmada öğrencilerin hemşirelik eğitimi sürecinde hemşirelik bakım davranışları algısında artış olduğu, cinsiyet açısından anlamlı farklılıkların olduğu, kadın öğrencilerin puan ortalamalarının daha yüksek olduğu belirlenmiştir. Hemşirelik bakımının felsefesi ve öneminin birinci sınıftan itibaren ve cinsiyetçi yaklaşımdan arındırılarak aktarılması önerilmektedir.Anahtar kelimeler: bakım davranışları, hemşirelik eğitimi, hemşirelik bakımı, hemşirelik öğrencisi
AtıfOpenAlex8TR Dizin9İncele - MakaleAçık Erişim2021Ebelik ve Hemşirelik Öğrencilerinin Covid 19 Salgını Hakkındaki Bilgileri ve Korunmaya Yönelik Aldıkları Önlemler
Orhan, Ilksen; Yılmaz, Ayşe Nur; Yüksekol, Özlem Doğan
Amaç: Bu araştırma ebelik ve hemşirelik öğrencilerinin Covid 19 ile ilgili bilgi düzeyleri ve korunmaya yönelik aldıkları önlemleri belirlemek amacıyla tanımlayıcı olarak yapıldı. Gereç ve Yöntemler: Araştırmanın evrenini bir ilin Sağlık Bilimleri Fakültesi Ebelik bölümünde okuyan 315 ve başka bir ilin hemşirelik bölümünde okuyan 200 öğrenci olmak üzere toplam 515 öğrenci oluştururken, araştırmanın örneklemini 395 öğrenci oluşturdu. Veriler 5-15 Mayıs tarihleri arasında, araştırmacılar tarafından hazırlanan anket formu ile online olarak toplandı. Araştırmada yüzde, frekans ve ki kare analizleri kullanıldı. Bulgular: Araştırmada öğrencilerin %90.09 oranında bilgi sahibi oldukları, %99’unun Covid 19 hastalığının belirtilerini doğru tanımladığı, %97.7’si hastalığı önlemek için alınabilecek tedbirleri doğru tanımladığı bulundu. Ayrıca öğrencilerin %93.66’sının korunma için çeşitli önlemler aldığı bulundu. Araştırmada Covid 19 virüsünün kuluçka süresi ortalama 4-14 gündür değişkenine doğru cevap verenler ile yanlış cevap verenler arasında okudukları bölümü isteyerek tercih etme ve okudukları bölümlere göre istatistiksel olarak anlamlı farklılık saptandı (p<0.05, Tablo 4). Önlem olarak yetkililerin yaptığı açıklamaları takip ettiklerini ve mümkün olduğunca bu önerilere uymaya çalıştıklarını ifade eden öğrenciler ile bu değişkene hayır cevabı veren öğrenciler arasında okudukları bölüme göre istatistiksel olarak anlamlı farklılık bulundu (p<0.05, Tablo 5). Sonuç: Öğrencilerin %66.6’sının Covid 19 ile ilgili tedavi konusunda yanlış bilgiye sahip oldukları saptandı. Ebelik ve hemşirelik bölümü öğrencilerine Covid 19 tedavisi konusunda eğitim verilmesi önerilebilir.Anahtar Kelimeler: Ebelik; Hemşirelik, Öğrenciler; Covid 19
AtıfOpenAlex6TR Dizin5İncele - MakaleYalnız künye2021İnsanlarda Ciddi Hastalıklara Neden Olan Bakteri, Maya ve Dermatofit Mantarları Üzerinde Poly (DMAA-co-MMA) 'nin İnhibe Edici Etkisi
Kirbag, Sevda; Sönmez, Pınar Erecevıt; Pıhtılı, Güzin
Bu çalışmada insanlarda ciddi hastalıklara neden olan bakteri, maya ve dermatofit mantarları gibi mikroorganizmalar üzerindeki poli dimetilakrilamid-ko-metilmetakrilat’ın poli P (DMAA-co-MMA) diklorometan içeren çözeltilerinin inhibitör etkilerini araştırıldı. Disk difüzyon yöntemi ile incelenen bu çözelti, Bacillus megaterium ve Klebsiella pneumoniae dışındaki tüm bakterilerin (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) ve dermatofit mantarlarının çoğalmasını engelleyerek antimikrobiyal özelliğe sahiptir. Antimikrobiyal duyarlılık verilerinde, diklorometan içinde çözünen poli P (DMAA-ko-MMA) maya ve dermatofit mantarlarının büyümesine karşı inhibe edici bir etkiye sahiptir (Candida spp. üzerinde 11.3mm / inhibisyon alanı - 12.3 mm / inhibisyon alanı) ve Epidermophyton sp. üzerinde 11.3 mm / inhibisyon alanı - Trichophyton sp. üzerinde 11.3 mm / inhibisyon alanı) (P <0.001). Disk difüzyon yöntemini güçlendiren MIC (Minimal inhibisyon konsantrasyonu) sınır değerleri bakteriler, mayalar, dermatofitlerin büyümesini engelleyen en küçük değer olarak 50-100 μL'dir (10 mL de 4500- 9000 μg). Antimikrobiyal bileşik, gelecek bu alandaki çalışmaları aydınlatmak için büyük avantaj sağlayabilir. Çalışmada kullanılan polimer, iltihaplanma ve mantar enfeksiyonlarına neden olan mikroorganizmalar ile savaşan antimikrobiyal polimerlere umut verici yeni bir katkı sağlayacaktır.
- MakaleAçık Erişim2021Scopus SJRQ3Effects of Chrysin on Carbon Tetrachloride-Induced Testicular Damage in Rats: Biochemical, Histopathological and Immunohistochemical Evaluation
Parlak Ak, Tuba; Seven, Pinar Tatli; Seven, Ismail; Mutlu, Seda Iflazoglu; Yaman, Mine; Sur, Aslihan; Gul, Burcu
The aim of this study was to evaluate the effect of chrysin on testicular damage induced by carbon tetrachloride (CCl4) in rats. Twenty-four male Spraque-Dawley rats were divided into four groups as the control group, Chrysin group, CCl4 group, and Chrysin+CCl4 group. Chrysin (100 mg/kg/body weight/day) and CCl4 (0.5 ml/kg/body weight/day in corn oil (1:1)) were administered by gavage for 14 days. Compared to the control group, it was determined that malondialdehyde (MDA) level increased, reduced glutathione (GSH) level, and superoxide dismutase (SOD) and catalase (KAT) activities decreased in the CCl4 group. It was also determined that many testicular lesions were induced, Johnsen’s Mean Testicular Biopsy Score (JMTBS) decreased, and caspase-3 immunoreactivity increased in this group. Compared to the CCl4 group, it was determined that GSH level and SOD and CAT activities increased, MDA level decreased in the Chrysin+CCl4 group. It was also observed that testicular lesions were alleviated, JMTBS increased, and caspase-3 immunoreactivity was decreased in this group. As a result, it was concluded that chrysin might have beneficial effects in the treatment of CCl4-induced testicular toxicity as a result of its antioxidant and anti-apoptotic properties.
AtıfOpenAlex2İncele - MakaleAçık Erişim2021Türkiye'de Kentsel Bir Atıksu Arıtma Tesisinde SARS-CoV-2 ve Gastrointestinal Patojenlerin Araştırılması
Topal, Murat; Topal, E.Işıl Arslan; Toraman, Zülal Aşçı; Süer, Ceren Sel; Öbek, Erdal
Bu çalışmada, Elazığ'da (Türkiye) bir kentsel atıksu arıtma tesisinde (AAT) SARS-CoV-2 ve gastrointestinal patojenler araştırılmıştır. Gastrointestinal patojen analizleri AAT giriş ve çıkış sularında, SARS-CoV-2 analizleri ise arıtma tesisinin farklı ünitelerinde yapılmıştır. Elde edilen analiz sonuçlarına göre AAT’nin girişinde gastrointestinal patojenler (bakteriyel, viral, EPA ve dışkı parazitleri) tespit edilmiştir. AAT'nin atıksularında enterohemorragik / verotoksin üreten Esherichia coli, gastroenterite neden olan tüm viral ajanlar (sapovirüsler (Sapo) hariç), insan parekovirüs (HPeV) ve EPA'dan adenovirüsler ve dışkı parazitlerinden Giardia lamblia tespit edilmiştir. AAT çıkışında gastroenterite neden olan bakteriyel ajanlar, viral ajanlar, EPA ve dışkı parazitleri incelendiğinde 7'de sadece 1, 6'da 4, 3'te 2 ve 3'te 1 ajan pozitif (+) olarak tespit edilmiştir. Atık su arıtma tesisinin her bir ünitesinden alınan numunelerde SARS-CoV-2 tespit edilememiştir. Sonuç olarak, araştırma bulgularına göre, atık su arıtma tesisi atık sularında patojenlerle karşılaşıldığından, çevre ve insan sağlığını korumak için arıtma tesislerinde dezenfeksiyon sistemine sahip olmak ve patojenleri ve SARS-CoV-2'yi sürekli izlemek gerekmektedir.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2021Antibacterial and Antifungal Features of Centaurea urvillei DC. subsp. urvillei that is herboized in Turkey
Cakilcioglu, Ugur; Sönmez, Pınar Erecevıt
Although there are many studies on the activities of different species, the compounds and effects of Centaurea L., the largest genus of the Turkish flora, on human health, no relevant studies have been conducted on the antimicrobial properties of the usable parts (above ground leaves, flowers) of C. urvillei DC. subsp urvillei against pathogenic microorganisms.This study aimed to show whether it prevents the growth of these microorganisms that cause infectious diseases in humans on bacteria, yeast, dermatophytes that cause infectious diseases in humans via well agar and microdilution method by applying a methanol solution of the usable parts of C. urvillei DC. subsp. urvillei. Regarding the antimicrobial susceptibility results, the plant solution formed a generally sensitive inhibition zone (14.66 mm-11.66 mm inhibition zone-1 diameter) on inhibition of growth of yeast, dermatophyte isolates and other bacteria. This means that 40 mg dose of C. urvillei DC. subsp. urvillei has antibacterial and antifungal that can prevent the growth of all test microorganisms (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Klepsiella pneumoniae clinical isolate, Candida albicans RSKK 02007, Candida glabrata RSKK 014019, Candida tropicalis RSKK 02011, Epidermophyton floccosum RSKK 14024, Trichophyton rubrum RSKK 03022) that cause disease. It is seen when we compared with the control group that there was no significant difference in bacteria, however, a significant difference was observed in yeast and dermatophytes (p
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2021Examination of The Attitudes of Cycling Athletes' Towards Ecorecreation
Albayrak, Veysel; Gacar, Atalay; Nacar, Eyyup; Tutar, Omer Faruk
Background: It is known that people's relations with nature can be greatly influential in all periods of their lives and especially in their future, which has increased their interest in concepts such as environment, nature, natural life, ecology, ecosystem as a result of the increase in natural awareness in humans. Aim: Based on these ideas, our research aims to measure the attitudes of cycling athletes in Elazig province towards ecorecreation.. Methods: A total of 178 athletes from 242 cycling athletes, including cycling sports clubs, associations, and individual athletes in Elazig province, participated voluntarily. It consists of 31 substances and 6 sub-dimensions developed by Ayyildiz and the 'Personal Information Form' prepared by the researchers as a data collection tool. Attitude Scale Towards Ecorecreation(ASTE), which was created in a 5-point Likert type format, was used. Spss 22.00 package program was used for the analysis of the data and the level of significance was determined as p<0.05. In the study, t-test analysis was applied to determine the significance of the differences between two groups and ANOVA was applied to determine the significance between more than two groups. Pearson correlation analysis was used to determine the direction and severity of the relationship between variables. Results: As a result of the research, there was a semantic difference in the individual and environmental sensitivities of licensed cycling athletes. A significant difference was observed in the Attitudes and Behavior towards Ecorecreation sub-dimensions of the athletes who are interested in another nature sport. Conclusion: The increase in positive behaviors towards nature has clearly become clear that it is directly related to being in nature. Accordingly, researchers believe and draw attention to the fact that in order to increase the positive effect on nature, it is necessary to be intertwined with nature and to adopt it.
- MakaleAçık Erişim2021Examining Addiction Levels of Tablet, Phone, and Computer Gaming According to the Parents' Opinions of Students Participating Summer Sports Schools
Albayrak, Veysel; Gacar, Atalay; Nacar, Eyyup; Tutar, Omer Faruk
Background: The universe of the research is the athletes of summer sports schools held in Elazig in 2021. The sample consists of the mothers of 669 randomly selected athletes from sports schools. Aim: The aim of the study is to examine the levels of gaming addiction according to the parental opinions of the students participating the 2021 Elazig Summer Sports Schools. Methods: In order to determine the demographic characteristics of the participants in the study, the personal information form(gender, age, school level, mother work status, child's tablet/phone ownership status), and an 18-item scale developed by Ulusoy (2019) was used. Analysis of the data in the research and the calculation of the results found were created through statistical programs in a computer environment. Frequency (f) and percentage (%) distributions of variables were calculated. The data were checked with skewness and kurtosis tests to determine whether they were normally distributed. As a result of these tests and controls, it was determined that the data of the research was parametric. Therefore, t test and variance analysis (Anova) test were used. The error level was taken as p<0.05 in the study. Results: It was determined that there was a statistically significant difference in computer game addiction depending on the gender, mother work status and tablet/phone/computer availability of the students participating summer sports schools in Elazig province. There was no statistically significant difference in computer game addiction depending on educational status and age variables. Conclusion: In line with the study findings, it was observed that the overall average of computer game addiction levels was below average at 45.30 within the framework of the parental opinions of the students participating summer sports schools in Elazig province.
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