Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleYalnız künye2024Scopus SJRQ2A risk assessment model with dependent failure modes for the manufacturing and design processes of medical equipment
Lo, Huai-Wei; Gul, Muhammet; Yucesan, Melih; Liaw, Ching-Fang
The reliability of medical equipment is paramount for surgical success. Manufacturers are continuously exploring risk assessment and improvement strategies to prevent equipment malfunctions during surgery. Failure mode and effects analysis (FMEA) can primarily be divided into two types: DFMEA (Design FMEA) and PFMEA (Process FMEA). Traditional FMEA serves as a practical tool for identifying and prioritizing key failure modes (FMs). However, past FMEA research has overlooked the interdependencies among FMs, treating them as independent entities, which does not align with real-world operations. This paper introduces a groundbreaking risk dependency assessment model aimed at addressing the influential relationships among FMs. The modified technique for defining the influential relationship of failure modes (modified TEDIR-FMs) is developed to compute the relative risk scores of different FMs accurately. At its core, this paper integrates concepts from multiple criteria decision-making (MCDM) techniques into FMEA, with a particular focus on the interdependencies of failure modes in the manufacturing and design manufacturing processes of medical equipment. The model’s application is demonstrated through a case study on a medical device for hernia surgery. The introduction of modified TEDIR-FMs not only enhances the accuracy of risk assessments but also offers a fresh perspective on risk management within the design and manufacturing processes. The research results indicate that the three failure modes with the highest risk are “adhesive does not deploy or only partially deploys from the dispenser,” “the mesh does not adhere to the adhesive,” and “the adhesive drips from the tip.” In the manufacturing and design processes of this device, greater attention should be given to improving the adhesive components.
AtıfScopus5WoS4OpenAlex2
İncele - MakaleYalnız künye2024Scopus SJRQ3Functionalized and Ag-Loaded Nano-Delivery System for Doxorubicin: Loading, Controlled Release and Kinetic Studies
Aydogdu, Burcu; Kaplan Ince, Olcay; Ince, Muharrem; Unal, Ilkay
Multi-walled carbon nanotubes (fMWCNTs) that functionalized and loaded Ag nanoparticles (AgNPs) were investigated to adsorp doxorubicin hydrochloride (DXR). DXR release behavior efficiency was determined using kinetic studies. DXR agent was treated into fMWCNTs@AgNPs material with different drug loading rates. The material was successfully established and characterized using transmission electron microscopy, and fourier transform–infrared spectroscopy. Thermogravimetric analysis was performed to elucidate the effect of temperature on mass loss and X-ray diffraction analysis was systematically assessed the crystalline state of DXR. Various kinetic models including Higuchi, Baker Hixson-Crowell, and power-law were applied. It was revealed that DXR has more binding affinity to the fMWCNTs@AgNPs material system surface as a nanocarrier at pH 7.4 and showed more release at pH 5.0. Functionalized material confirmed its efficiency as pH-based drug delivery system. Used material can be utilized as promising nanocarriers, and findings will contribute to the rational design of novel delivery tools for drugs.
- MakaleYalnız künye2024Scopus SJRQ2Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2-treated HDF cells of the extracts of Stachys tundjeliensis
Kurt-Celep, Inci; Zheleva-Dimitrova, Dimitrina; Sinan, Kouadio Ibrahime; Uba, Abdullahi Ibrahim; Nilofar; Mahomoodally, Mohamad Fawzi; Aumeeruddy, Muhammad Zakariyyah; Cakilcioglu, Ugur; Dall'Acqua, Stefano; Zengin, Gokhan
The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts from aerial parts of Stachys tundjeliensis. The obtained results showed that the ethanol extract exhibited the highest antioxidant activity in the antioxidant assays. Meanwhile, the ethanol extract displayed strong inhibitory activity against α-tyrosinase, the dichloromethane extract exhibited potent inhibition against butyrylcholinesterase, and the n-hexane extract against α-amylase. Based on ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry analysis, more than 90 secondary metabolites, including hydroxybenzoic acid, hydroxycinnamic acid, and their glycosides, acylquinic acids, phenylethanoid glycosides, and various flavonoids were identified or tentatively annotated in the studied S. tundjeliensis extracts. It was observed that the application of S. tundjeliensis eliminated H2O2-induced oxidative stress. It was determined that protein levels of phospho-nuclear factor kappa B (NF-κB), receptor for advanced glycation endproducts, and activator protein-1, which are activated in the nucleus, decreased, and the synthesis of matrix metalloproteinase (MMP)-2 and MMP-9 also decreased to basal levels. Overall, these findings suggest that S. tundjeliensis contains diverse bioactive compounds for the development of nutraceuticals or functional foods with potent biological properties.
AtıfScopus12OpenAlex12
İncele - MakaleYalnız künye2024Scopus SJRQ1Parental mediation in Turkey: The use of mobile devices in early childhood
Aslan, Alper; Turgut, Yigit Emrah
This study aims to investigate the use of mobile devices including smartphones and tablets in terms of mediation types of parents who have young children. In this case study, which is one of the qualitative research methods, criterion sampling was adopted for the selection of the study group. The fact that parents of 4–7-year-old children who use mobile devices is determined as the principal criterion. Twelve children aged 4–7 and their parents participated in the study. Data were collected through child observations and parent interviews. The results indicated that children with the mediation of parental supervision had fewer problematic behaviors in the use of media and faced fewer online risks. Besides, children whose parents have general restrictive mediation were the most likely to exhibit problematic media use behaviors. Children whose parents have active mediation were also the most likely to face Internet risks. It was observed that children frequently played games and watched videos on mobile devices. Most parents considered their children’s use of mobile devices as risky and harmful, while it was considered as useful only by co-using parents. It was found that children’s use of mobile devices causes physical, psychological, communicational, and cognitive issues while improving their academic abilities, interests, and cognitive structures. Nevertheless, it was discovered that parents used mobile devices to convince their children to go through their daily routines such as eating, bathing, and sleeping or calm them down in the workplace or social environments.
AtıfScopus9WoS8OpenAlex13İncele - MakaleAçık Erişim2024Scopus SJRQ1Integrating chemical analysis with in vitro, in silico, and network pharmacology to discover potential functional compounds from Marrubium astracanicum subsp. macrodon
Avşar, Ömer Kaan; Kasbolat, Sevgi; Ak, Gunes; Nilofar; Caprioli, Giovanni; Santanatoglia, Agnese; Uysal, Ahmet; Uba, Abdullahi Ibrahim; Ponniya, Sathish Kumar M.; Paksoy, Mehmet Yavuz
The members of the genus Marrubium are of great interest because they contain biologically active compounds. With in this mind, we aimed to examine the chemical profiles and biological activities (antioxidant, enzyme inhibition and antimicrobial effects) of different extracts of Marrubium astracanicum subsp. macrodon. Extractions of the plants were carried out with the solvent n-hexane, acetone, acetone/water (70 %), and water. The antioxidant activity of these extracts was evaluated through six different assays, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), metal chelating ability (MCA), and phosphomolybdenum (PBD). Additionally, the inhibitory effects of these solvents on five enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase were investigated. The study detected 38 compounds in a plant, with the highest content in acetone and acetone/water extracts. The acetone/water extract demonstrated the highest antioxidant activity aligning with its superior total phenolic (51.9 mg gallic acid equivalent (GAE)/g) and flavonoid (31.0 mg rutin equivalent (RE)/g) content, highlighting a direct correlation between bioactive compound concentration and antioxidant potential across various assays. Regarding the enzyme inhibition activity, the acetone/water extract of this plant exhibited significant AChE inhibition measuring 2.5 mg galantamine equivalent (GALAE)/g and anti-glucosidase activity measuring 1.2 mmol acarbose equivalent (ACAE)/g. In antimicrobial evaluation, the acetone extract exhibited good antimicrobial activity against B. cereus at 0.2 mg/ml dose. In molecular docking analysis, delphinidin 3,5 diglucoside showed a good interaction with the active site of AChE active. Through the application of network pharmacology, an in-depth exploration was conducted to unravel the potential of compounds from M. astracanicum against Alzheimer's disease. The study specifically focused on identifying key targets within the Alzheimer's disease pathway, pinpointing crucial proteins such as Glycogen synthase kinase-3 (GSK3), Prostaglandin-endoperoxide synthase 2 (PTGS2), and Alzheimer's-associated amyloid precursor protein (APP). In summary, the plant can serve as a valuable ingredient in the production of functional products within the pharmaceutical, nutraceutical, and cosmeceutical applications.
AtıfScopus4OpenAlex4İncele - MakaleAçık Erişim2024Scopus SJRQ2Cytotoxic, antioxidant, and enzyme inhibitory activities of Centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored Centaurea species
Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, María; Jiménez, Francisco-Javier Leyva; Uba, Abdullahi Ibrahim; Ak, Gunes; Soomro, Sanam Iram; Balos, Maruf; Cakilcioglu, Ugur; Rodrigues, Maria João
The members of the genus Centaurea have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of Centaurea stapfiana, an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non-tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- > 6)-glucoside and iNOS. In summary, our results suggest that C. stapfiana can be considered as a versatile raw material for the development of health-promoting applications in the pharmaceutical and cosmeceutical fields.
AtıfScopus13OpenAlex14İncele - MakaleAçık Erişim2024Scopus SJRQ4Erythropoietin and Hypericum perforatum ameliorate Gentamicin–induced nephrotoxicity in rats; [La eritropoyetina y el Hypericum perforatum mejoran la nefrotoxicidad inducida por gentamicina en ratas]
Ak, Tuba Parlak; Sağıroğlu, Meltem; Korkmaz, Gizem Elif; Yaman, Mine
Gentamicin (GM), which causes nephrotoxicity, is an aminoglycoside antibiotic commonly prescribed to treat of gram–negative infections. Erythropoietin (EPO), which has several biological functions including neuroprotection, wound healing and nephroprotection, is a glycoprotein hormone that controls erythropoiesis. Hypericum perforatum (HP) is a medicinal herb with antibacterial and nephroprotective effects. The aim of this study is to demonstrate the efficacy of EPO and HP in GM nephrotoxicity using combined biochemical, histopathological and immunohistochemical evaluations together. A total of 36 male Spraque–Dawley rats were divided into as control, GM (100 mg·kg-1 day), GM+EPO, GM+HP, EPO (1000 IU·kg-1 three consecutive days apart) and HP (200 mg·kg-1 day) groups (n=6) and the experiment lasted for 9 days. GM–induced increased relative kidney weight and increased serum urea nitrogen (BUN), creatinine and urea levels were reduced by EPO and HP. EPO and HP reduced the level of malondialdehyde (MDA), which increased with GM application, and increased the activities of reduced glutathione (GSH), glutathione peroxidase (GSH–Px), and catalase (CAT). GM nephrotoxicity resulted in tubular degeneration, vacuolization and hyaline deposits, glomerular degeneration and interstitial mononuclear cell infiltration. EPO and HP attenuated these histopathological changes. Also, EPO and HP also reduced caspase–3 immunoreactivities, which increased with GM application. It was shown that EPO and HP have attenuating effects on GM–induced kidney injury, and especially the intense antioxidant content of HP has a regulatory effect on the negative consequences of oxidative stress.
- MakaleAçık Erişim2024Scopus SJRQ1Spread patterns of COVID-19 in European countries: hybrid deep learning model for prediction and transmission analysis
Utku, Anıl; Akcayol, M. Ali
The COVID-19 pandemic has profoundly impacted healthcare systems and economies worldwide, leading to the implementation of travel restrictions and social measures. Efforts such as vaccination campaigns, testing, and surveillance have played a crucial role in containing the spread of the virus and safeguarding public health. There needs to be more research exploring the transmission dynamics of COVID-19, particularly within European nations. Therefore, the primary objective of this research was to examine the spread patterns of COVID-19 across various European countries. Doing so makes it possible to implement preventive measures, allocate resources, and optimize treatment strategies based on projected case and mortality rates. For this purpose, a hybrid prediction model combining CNN and LSTM models was developed. The performance of this hybrid model was compared against several other models, including CNN, k-NN, LR, LSTM, MLP, RF, SVM, and XGBoost. The empirical findings revealed that the CNN-LSTM hybrid model exhibited superior performance compared to alternative models in effectively predicting the transmission of COVID-19 within European nations. Furthermore, examining the peak of case and death dates provided insights into the dynamics of COVID-19 transmission among European countries. Chord diagrams were drawn to analyze the inter-country transmission patterns of COVID-19 over 5-day and 14-day intervals.
AtıfScopus6WoS3OpenAlex7İncele - MakaleAçık Erişim2024Scopus SJRQ1Exploring Chemical Composition, Antioxidant, Enzyme Inhibitory and Cytotoxic Properties of Glaucium acutidentatum Hausskn. & Bornm. from Turkey Flora: A Novel Source of Bioactive Agents to Design Functional Applications
Yagi, Sakina; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Maciejewska-Turska, Magdalena; Sieniawska, Elwira; Świątek, Łukasz; Rajtar, Barbara; Bahşi, Muammer; Guler, Osman; Dall’Acqua, Stefano
The present study was performed to determine the chemical constituents, cytotoxicity, antioxidant and enzyme inhibition activities of the aerial parts of Glaucium acutidentatum Hausskn. and Bornm. (family Papaveraceae). Methanolic and aqueous extracts were prepared by maceration, homogenizer-assisted extraction (HAE) and infusion. Results showed that the highest total phenolic and flavonoids contents were obtained from the methanol extracts obtained by HAE (53.22 ± 0.10 mg GAE/g) and maceration (30.28 ± 0.51 mg RE/g), respectively. The aporphine, beznyltetrahydroisoquinoline, and protopine types of Glaucium alkaloids have been tentatively identified. Among them, glaucine was identified in all extracts. Flavonoids, phenolic acids, coumarins, organic acids and fatty acids were also detected. Methanolic extract obtained using the HAE method displayed the highest anti-DPPH (41.42 ± 0.62 mg TE/g), total antioxidant (1.20 ± 0.17 mmol TE/g), Cu2+ (113.55 ± 6.44 mg TE/g), and Fe3+ (74.52 ± 4.74 mg TE/g) reducing properties. The aqueous extracts obtained by infusion and HAE methods exerted the best anti-ABTS (103.59 ± 1.49 mg TE/g) and chelating (19.81 ± 0.05 mg EDTAE/g) activities, respectively. Methanolic extract from HAE recorded the highest acetylcholinesterase (2.55 ± 0.10 mg GALAE/g) and α-amylase (0.51 ± 0.02 mmol ACAE/g) inhibition activities, while that obtained by maceration showed the best butyrylcholinesterase (3.76 ± 0.31 mg GALAE/g) inhibition activity. Both extracts revealed the best tyrosinase inhibitory activity (25.15 ± 1.00 and 26.79 ± 2.36 mg KAE/g, p ≥ 0.05). G. acutidentatum maceration-derived aqueous extract showed selective anticancer activity against cells originating from human hypopharyngeal carcinoma. In conclusion, these findings indicated that G. acutidentatum is a promising source of alkaloids and phenolic compounds for variable pharmaceutical formulations.
AtıfScopus13OpenAlex13İncele - MakaleYalnız künye2024Scopus SJRQ1Virtual reality for COPD exacerbation: A randomized controlled trial
Kizmaz, Erhan; Telli Atalay, Orçin; Çetin, Nazlı; Uğurlu, Erhan
Background: Pulmonary rehabilitation (PR) is an effective treatment method for chronic obstructive pulmonary disease (COPD). However, individuals with chronic diseases that require lifelong treatment and experience exacerbations need motivational methods. Objectives: The aim of this study was to examine the effects of virtual reality on symptoms, daily living activity, functional capacity, anxiety and depression levels in COPD exacerbation. Methods: Fifty patients hospitalized for COPD exacerbation were included in the study. They were randomly assigned to two groups. Twenty-five patients participated in a traditional PR (once-daily until discharge), including pedaling exercises. The second/25 patients followed the same protocol but experienced cycling simulation in the forest via virtual reality (VR + PR). All patients were evaluated using 1-minute/Sit-to-Stand test (STST), modified-Medical Research Council (mMRC) scale, COPD Assessment test (CAT), Hospital Anxiety and Depression Scale (HADS), and London Chest Activities of Daily Living (LCADL) before and after the treatment. Results: The STST showed an increase in both groups post-treatment, notably higher in the VR + PR (p = 0.037). Dyspnea levels and CAT scores decreased in all patients, but the decrease was greater in the PR + VR group for both parameters (p = 0.062, p = 0.003; respectively). Both groups experienced a reduction in the HADS scores compared to the pre-treatment, with a more significant decrease in depression and the total score in the VR + PR (p < 0.05). LCADL's sub-parameters and total score, excluding household, decreased in both groups after treatment (p < 0.05). The improvement was more substantial in the VR + PR. Conclusions: Virtual reality provides benefits in the management of COPD exacerbations and can be used safely. Clinical trial registiration: Registered at clinicaltrials.gov, registration ID: NCT05687396, URL: www.clinicaltrials.gov.
AtıfScopus11WoS11OpenAlex15İncele - MakaleAçık Erişim2024Scopus SJRQ1A broad-spectrum biological activities of Heracleum humile extracts: A first report of the antiviral, anti-cancer and chemical properties
Ocal, Mustafa; Duran Yelken, Selda; Altunoglu, Yasemin Celik; Baloglu, Mehmet Cengiz; Soomro, Sanam Iram; Zengin, Gokhan; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Paksoy, Mehmet Yavuz
The current work focused on researching the bioactive potential of ethyl acetate (EA), methanol (MeOH), and water extract of H. humile plant, specifically ethyl acetate, methanol extracts were acquired with maceration method, and water extract was obtained by the infusion method. The highest total phenolic ingredient was determined in the water extract, while the highest total flavonoid ingredient was found in the MeOH extract. The water extract displayed the most potent antioxidant activity in the assays used. The ethyl acetate extract showed the highest enzyme inhibition activity in Butyrylcholinesterase inhibition (BChE) and amylase assay. Antibacterial efficiency was analyzed using microdilution analysis. The minimum inhibitory concentration (MIC) amounts ranged from 125 to 500 μg/mL except for water extract. The antiviral potential of the extracts was assessed against Bovine herpes virus 1 (BoHV-1) (Cooper strain). Methanol extract showed more potent antiviral effect. Selectivity indices were calculated for ethyl acetate and methanol extract as 3.32 and 13.39, respectively. All extracts displayed Deoxyribonucleic Acid (DNA) protection activity at approximately 25%–35%. For cell viability evaluation, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) test was performed against triple-negative human breast adenocarcinoma cells (MDA-MB-231) and Michigan Cancer Foundation-7 (MCF-7) cells. The most effective results were found in ethyl acetate extract at 48h. The 50% inhibitor concentrations (IC50) were determined for MDA-MB-231 and MCF-7 as 116.7 μg/mL and 247.9 μg/mL, respectively. Based on the bioactive compound content results, extracts of H. humile include valuable compounds that possess significant biological properties. In conclusion, these extracts could offer promising novel plant-derived therapeutics.
- MakaleAçık Erişim2024Scopus SJRQ2Effects of naringenin on oxidative damage and apoptosis in liver and kidney in rats subjected to chronic mercury chloride
Kahramanoğullari, Merve; Erişir, Mine; Yaman, Mine; Parlak Ak, Tuba
Mercury chloride is a type of heavy metal that causes the formation of free radicals, causing hepatotoxicity, nephrotoxicity and apoptosis. In this study, the effects of naringenin on oxidative stress and apoptosis in the liver and kidney of rats exposed to mercury chloride were investigated. In the study, 41 2-month-old male Wistar-Albino rats were divided into five groups. Accordingly, group 1 was set as control group, group 2 as naringenin-100, group 3 as mercury chloride, group 4 as mercury chloride + naringenin-50, and group 5 as mercury chloride + naringenin-100. For the interventions, 1 mL/kg saline was administered to the control, 0.4 mg/kg/day mercury (II) chloride to the mercury chloride groups by i.p., and 50 and 100 mg/kg/day naringenin prepared in corn oil to the naringenin groups by gavage. All the interventions lasted for 20 days. Mercury chloride administration was initiated 1 h following the administration of naringenin. When mercury chloride and the control group were compared, a significant increase in plasma urea, liver and kidney malondialdehyde (MDA) levels, in kidney superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) activities (p <.001), and a significant decrease in liver and kidney glutathione (GSH) levels (p <.001), in liver catalase (CAT) activity (p <.01) were observed. In addition, histopathological changes and a significant increase in caspase-3 levels were detected (p <.05). When mercury chloride and treatment groups were compared, the administration of naringenin caused a decrease aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) (p <.01), urea, creatinine levels (p <.001) in plasma, MDA levels in liver and kidney, SOD, GSH-Px, GST activities in kidney (p <.001), and increased GSH levels in liver and kidney. The addition of naringenin-100 increased GSH levels above the control (p <.001). The administration of naringenin was also decreased histopathological changes and caspase-3 levels (p <.05). Accordingly, it was determined that naringenin is protective and therapeutic against mercury chloride-induced oxidative damage and apoptosis in the liver and kidney, and 100 mg/kg naringenin is more effective in preventing histopathological changes and apoptosis.
AtıfScopus13WoS14OpenAlex14İncele - MakaleYalnız künye2024Scopus SJRQ3Biogenic Silver and Zinc Enhanced MWCNTs: Nano-Decoration, Characterization, and Antimicrobial Effect
Ünal, İlkay
In this study, acid-treated multi-walled carbon nanotubes (MWCNTs) were decorated with silver (Ag), zinc (Zn), and Ag@Zn nanoparticles (NPs) synthesized using plant extract for reducing and stabilizing NPs. The nanocomposites were characterized by Scanning electron microscopy (SEM)-energy-dispersive X-ray spectroscopy (EDX), Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and Thermogravimetric analysis (TGA). The stability of functionalized MWCNTs (f-MWCNTs) and NP-decorated MWCNTs was visually evaluated for seven days in ethanol. The antimicrobial efficacy against Gram-positive (Staphylococcus aureus), Gram-negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and fungi (Candida albicans) was determined using the agar well diffusion assay. Results indicated that Ag-MWCNTs and Ag@Zn-MWCNTs nanocomposites exhibited superior antimicrobial activity against P. aeruginosa and C. albicans compared to other tested microorganisms. Conversely, f-MWCNTs and Zn-MWCNTs showed no antimicrobial effects.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ3Toxicity assessment of advanced biological wastewater treatment plant effluent by integrated biomarker response in zebra mussels (Dreissenapolymorpha)
Serdar, Osman; Ketenalp, Zozan; Yildirim, Nuran Cikcikoglu
In this study, zebra mussels (Dreissena polymorpha) were exposed to advanced biological wastewater treatment plant effluent (ABWTPE) for 96 h. At the end of the 96th hour, antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), malondialdehyde (MDA) and glutathione (GSH) were examined. The objective of the study was to identify biomarkers that are useful for assessing the potential toxic effects of ABWTPE in freshwater environments. We observed an increase in GPX, SOD activity and MDA levels, and a decrease in CAT, GST activity and GSH levels. The results obtained in our study showed that the measured biochemical parameters (GSH, MDA, SOD, CAT, GPX and GST) are useful biomarkers in determining the possible toxicity of ABWTPE in aquatic environments.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model
Sahin, Kazim; Gencoglu, Hasan; Korkusuz, Ahmet Kayhan; Orhan, Cemal; Aldatmaz, İsmail Ertuğ; Erten, Fusun; Er, Besir; Morde, Abhijeet; Padigaru, Muralidhara; Kilic, Ertugrul
Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.
AtıfScopus19OpenAlex19İncele - BildiriYalnız künye2024An Analysis of Dependence Relationships Between Covid-19 Pandemic and Environmental Conditions Cases Study in Indonesia, England, and Türkiye
Handhayani, Teny; Caglar, Durdane Kocacoban; Wibowo, F.W.
This study explores the causal relationships between environmental conditions and Coronavirus disease 2019 (COVID-19) using Bayesian networks in three geographically distinct cities: Jakarta (Indonesia), London (England), and Istanbul (Türkiye). The datasets collected from these cities span from January 2020 to October 2022, encompassing a variety of environmental variables (Particulate Matter (PM2.5), temperature, humidity, precipitation, wind speed, and Ultraviolet (UV) index) and COVID-19 variables (new cases, deaths, and population density). By using the PC algorithm and Greedy Equivalence Search (GES) to generate causal graphs, and applying the Intersection-Validation (InterVal) method to derive agreement graphs, this research reveals significant geographical differences in how environmental factors influence COVID-19 dynamics. The Peter-Clark (PC) algorithm identifies conditional dependencies, while GES optimizes the structure of the causal graph. The study highlights the significant impact of temperature, UV index, and humidity on COVID-19 dynamics, emphasizing the importance of localized public health strategies tailored to specific environmental conditions. These findings contribute to the understanding of environmental influences on COVID-19 and offer valuable insights for future research and policy-making aimed at mitigating the impact of pandemics in diverse geographical settings.
AtıfScopus3OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ1The Mediating Effect of Experiential Avoidance on the relationship between psychological resilience and psychological needs in the COVID-19 pandemic
Dursun, Asiye; Kaplan, Yılmaz; Altunbaş, Tuğçe; Bahtiyar, Muhammed
The COVID-19 pandemic that has impinged upon the world affects individuals not only physically but also psychologically. Considering the effects of the pandemic that can be called a challenging life event, the concept of psychological resilience comes to mind. In this study, the effect of multidimensional avoidance on the relationship between psychological resilience and psychological need satisfaction-frustration of adults is discussed through structural equation modeling. The study data were collected online from 506 adults who participated voluntarily from 7 different geographical regions of Turkey. The study findings were obtained by using correlation analysis, structural equation modeling, and path analysis. As a result of the study, it is seen that all the variables of multidimensional avoidance except distraction/suppression and frustration directly affect psychological resilience in satisfaction and frustration of basic psychological needs. In addition, it shows that psychological resilience has a significant effect on satisfaction and frustration of basic psychological needs, both directly and indirectly through multidimensional avoidance.
AtıfScopus13WoS15OpenAlex13İncele - MakaleAçık Erişim2024Scopus SJRQ1Evaluation of antioxidant, antimicrobial, and bioactive properties and peptide sequence composition of Malatya apricot kernels
Aydın, Çağlar Mert; Çelikbıçak, Ömür; Hayaloğlu, Ali Adnan
BACKGROUND: This study used four different apricot (Prunus armeniaca) kernels cultivated in Malatya during two consecutive years. The varieties were Hacihaliloglu, Hasanbey, Kabaasi, and Zerdali. The physicochemical properties of the kernels were determined, and the bioactive content of the kernels was evaluated using kernel hydrolysates prepared using trypsin. RESULTS: With regard to the physicochemical properties of the kernels, the dry matter ratio and protein content were the highest in the Hacihaliloglu variety; the ash ratio was the highest in the Kabaasi variety, and the free oil ratio was the highest in the Hasanbey variety. The bioactive compound content changed according to kernel variety. Angiotensin-converting enzyme inhibitors activity was found to be the highest in the Hacihaliloglu and Hasanbey varieties, which had the lowest amygdalin content, and Zerdali had the highest amygdalin content. The antioxidant and antimicrobial effects of the kernels varied, with Hasanbey and Kabaasi generally having the highest content in both analyses. Moreover, a concentration of 20 mg mL−1 of the hydrolysate was determined to have a destructive effect for the microorganisms used in this study. The storage protein of the kernels, except Hacihaliloglu, was found to be Prunin 1, with the longest matching protein chain in the kernels being R.QQQGGQLMANGLEETFCSLRLK.E. CONCLUSION: The results suggest that the peptide sequences identified in the kernels could have antihypertensive, antioxidative, and Dipeptidyl peptidase IV (DPP-IV) inhibitory effects. Consequently, apricot kernels show potential for use in the production of functional food products. Of the kernels evaluated in this study, Hacihaliloglu and Hasanbey were deemed the most suitable varieties due to their higher bioactive content and lower amygdalin content.
AtıfScopus13WoS11OpenAlex12İncele - MakaleYalnız künye2024Scopus SJRQ2Maxillary sinus detection on cone beam computed tomography images using ResNet and Swin Transformer-based UNet
Çelebi, Adalet; Imak, Andaç; Üzen, Hüseyin; Budak, Ümit; Türkoğlu, Muammer; Hanbay, Davut; Şengür, Abdulkadir
Objectives: This study, which uses artificial intelligence-based methods, aimed to determine the limits of pathologic conditions and infections related to the maxillary sinus in cone beam computed tomography (CBCT) images to facilitate the work of dentists. Methods: A new UNet architecture based on a state-of-the-art Swin transformer called Res-Swin-UNet was developed to detect the sinus. The encoder part of the proposed network model consists of a pre-trained ResNet architecture, and the decoder part consists of Swin transformer blocks. Swin transformers achieve powerful global context properties with self-attention mechanisms. Because the output of the Swin transformer generates sectorized features, the patch expanding layer was used in this section instead of the traditional upsampling layer. In the last layer of the decoder, sinus diagnosis was conducted through classical convolution and sigmoid function. In experimental works, we used a data set including 298 CBCT images. Results: The Res-Swin-UNet model achieved more success, with a 91.72% F1-score, 99% accuracy, and 84.71% IoU, outperforming the state-of-the-art models. Conclusions: The deep learning-based model proposed in the present study can assist dentists in automatically detecting the boundaries of pathologic conditions and infections within the maxillary sinus based on CBCT images.
AtıfScopus21OpenAlex20İncele - MakaleAçık Erişim2024Scopus SJRQ2An evaluation of societal perception of monkeypox in terms of disease anxiety and stress levels: A Turkish sample
Yeşiltepe, Akgün; Ayşe, Ç.A.L.
Objective: The purpose of this research was to examine community perception of monkeypox in terms of epidemic anxiety and stress levels. Methods: This research was performed as a descriptive, cross-sectional study. The research was conducted with 1001 individuals between September and December 2022. AMOS 24, JAMOVI, and SPSS version 25 software were employed. The data were collected using a descriptive form, the Epidemic Anxiety Scale, and the Perceived Stress Scale. Results: The mean Epidemic Anxiety Scale score was 52.47 ± 14.52, and the mean Perceived Stress Scale score was 41.88 ± 6.83. Significant positive correlation was determined between the Epidemic Anxiety Scale and the Perceived Stress Scale (r = 0.350, p =.000). A one-unit increase in perceived stress caused a 0.360 increase in epidemic anxiety (ß = 0.360). In addition, having heard of and fearing monkeypox, thinking about its ability to cause an epidemic, and perceived stress emerged as significant predictors of epidemic anxiety. Conclusion: The community was found to exhibit a moderate level of epidemic anxiety and a low level of perceived stress. Epidemic anxiety levels increased in line with perceived stress levels. We recommend that individuals in need receive support by determining epidemic anxiety and perceived stress levels in the community.
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