Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2024Effects of Porosity and Boron Reinforcement in AISI 316L Stainless Steel for Biomedical Applications
Aslan, Naim; Aksakal, Bunyamin; Fidan, Ferzan
AISI 316L stainless steel (SS) is one of the most widely used biomaterials in the manufacture of implants and biomaterials. It has advantages over equivalent biomaterials such as low cost, good mechanical properties and biocompatibility. The pores found in porous biomaterials provide mechanical interlock, ensuring strong attachment of the implant to the tissue. In this study, 20%, 30% and 40% by volume of polyvinyl alcohol (PVA) and Boron powder were added into 316L powder to obtain porous SS implant. To investigate the effect of porosity and boron effect on the stainless-steel implant material, the samples produced in PVA and Boron added groups, were sintered at 1180 oC under an argon atmosphere. With the evaporation of PVA in the structure, porous and boron added samples were obtained in two groups. Finally, the samples were subjected to Brinell hardness and compression tests and analyzed by SEM, EDS and XRD. As a result of the hardness tests, the highest values were measured as 37.006, 31.32, 25.28 HB. 39.5, 34.5, 26.2 MPa strengths were measured for 20%, 30% and 40% porous samples respectively.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2024Hangisi Daha Zorlayıcı? HIV ile Yaşamak Mı Yoksa İnsan Hakları İhlalleri Mi? HIV ile Yaşayan Kişilerin Maruz Bırakıldıkları İnsan Hakları İhlallerine Sosyal Hizmet Perspektifiyle Bir Bakış
Buz, Sema; Akbaş, Avşin
HIV, ürettiği damgalama, ayrımcılık ve insan hakları ihlalleriyle sadece viral bir enfeksiyon olmadığını aynı zamanda biyopsikososyal bir sağlık problemi olduğunu ortaya çıktığı günden bu yana yaklaşık 40 yıl içerisinde bizlere göstermiştir. HIV ile yaşayan kişiler bir yandan tıbbi tedaviyle uğraşırken diğer yandan HIV tanısının neden olduğu insan hakları ihlalleri, ayrımcılık ve damgalanma ile mücadele etmek durumunda kalmaktadır ve bu nedenle daha zorlu bir süreci deneyimlemektedir. Çalışmada Türkiye’de yayınlanmış olan HIV/AIDS alanına ilişkin insan hakları ihlalleri raporları üzerinden sosyal hizmet perspektifi ile bir değerlendirme yapmak ve insan hakları ihlallerine karşı çözüm yolları geliştirebilmek amaçlanmıştır. Bu çalışmada nitel araştırma yöntemlerinden doküman analizi metodu kullanılarak Türkiye’de HIV ile yaşayan kişiler tarafından kurulan ilk dernek olan Pozitif Yaşam Derneği’nin yayınlamış olduğu on dokuz rapor değerlendirilmiştir. Raporlardan insan hakları ihlallerinin sırasıyla en çok sağlık kuruluşları, işyerleri, kamu kurum ve kuruluşları, aile/sosyal çevre ve medyada gerçekleştiği ve çoklu insan hakları ihlallerinin yaşandığı ve raporların yayınlandığı tarihlerden günümüze gelindikçe insan hakları ihlallerine karşı daha fazla aksiyon alındığı tespit edilmiştir. Bu çalışma sosyal eşitsizlik ve adaletsizlikle mücadele eden sosyal hizmet uzmanlarının HIV ile yaşayanlara yönelik gerçekleştirilen insan hakları ihlallerine karşı mikro, mezzo ve makro boyutlarda uygulamalar gerçekleştirmesi gerektiğini ortaya koymaktadır.
AtıfOpenAlex2İncele - MakaleAçık Erişim2024Belediyelerin afet yönetimi kapasitelerinin değerlendirilmesi
Baş, Kazım
Belediyelerin afet yönetiminde rollerini yerine getirebilmeleri için yetki ve kapasitelerinin yeterli olmasının yanında merkezi yapılarla farklı seviyelerde işbirliği ve koordinasyona ihtiyaç duyulmaktadır. Bu araştırma, belediye çalışanlarının afet yönetiminde belediyelerin kapasiteleriyle ilgili görüşlerini değerlendirmek amacıyla yürütülmüştür. Tanımlayıcı türden olan araştırma, bir il ile ilçe belediyelerinde 20 Kasım 2023, 15 Ocak 2024 tarihleri arasında yürütüldü. Veri toplama aracı olarak araştırmacı tarafından geliştirilen “Çalışanları Tanıtıcı Form” ile “Çalışanların Afet Yönetiminde Belediyelerin Kapasiteleriyle İlgili Görüşlerini İçeren Form” kullanıldı. Araştırma evrenini, bir il ve ilçe belediyelerinde sürekli çalışan 260 kişi oluşturmuştur. Araştırmanın örneklemini ise işyerlerinde ulaşılabilen ve araştırmaya gönüllü katılan 148 (%56.92) belediye çalışanı oluşturdu. Verilerin analizinde sayı, yüzde, ortalama, standart sapma kullanıldı. Yaşların ortalaması 40.53±9.48 olan çalışanların, %60.1’i erkek, %29.7’si lisans mezunu olup, %42.6’sı işçi olarak çalışmakta, %29.0’unun belediyelerde 1-4 yıl çalışma deneyimine sahip olduğu görülmüştür. Çalışanlara göre belediyelerde afet yönetiminde; eğitim verilmediği (%71,6’sı), son iki yılda herhangi bir tatbikat yapılmadığı (%87.2’sı), belediyelerin afet yönetimine hazır olmadığı (%79.7’u) ve afet yönetiminde belediye bütçesinin yetersiz (%86.5’i), insan kaynakları sayısının (%77.0’si) yetersiz olduğu görülmüştür. Ayrıca çalışanlara göre belediyelerin afet yönetiminde en önemli üç sorunun ise nitelikli teknik personel ve ekipman eksikliği (%59.5), yetersiz bütçe (%45.9) ile eğitim eksikliğinin olduğu (%37.2) saptanmıştır. Araştırmada elde edilen bulgulara göre çalışanların büyük çoğunluğuna (%75’in üzerinde) göre belediyelerin afet yönetiminde kapasitelerinin yetersiz olduğu görülmüştür. Belediyelerin afet yönetiminde etkili ve başarılı olabilmeleri için yetkilerinin arttırılarak kapasitelerini geliştirici politikaların hayata geçirilmesi önerilmektedir.
AtıfOpenAlex4TR Dizin3İncele - MakaleAçık Erişim2024Hemşirelerin kültürel zekâları, iletişim becerileri ve ilişkili faktörler: bir yol analizi
Orhan, Ilksen; Ünal, Esra; Yıldız, Erman; Ağralı, Cansu
Bu araştırma, hemşirelerin kültürel zekâlarını, iletişim becerilerini ve ilişkili faktörleri belirlemek amacıyla yapıldı. Kesitsel ve ilişki arayıcı tasarımdaki araştırma, bir hastanede çalışmaya katılımda gönüllü 410 hemşire ile Mayıs-Ağustos 2023 tarihleri arasında gerçekleştirildi. Veriler, “Tanıtıcı Bilgi Formu, Kültürel Zekâ Ölçeği ve İletişim Becerileri Ölçeği” olmak üzere üç bölümden oluşan Google Form uygulamasıyla çevrim içi ortamda toplandı. Kültürel Zekâ Ölçeği (KZÖ) ve İletişim Becerileri Ölçeğini (İBÖ) etkileyen faktörleri belirlemek için yol analizi yapıldı. Bu araştırmada, Kültürel zekâ ile iletişim becerileri arasında orta derecede güçlü ve olumlu bir ilişki olduğu tespit edildi. Kültürel zekâyı etkileyen faktörler olarak cinsiyet, eğitim düzeyi ve yaş önemli bulundu. Bu faktörler, kültürel zekâ puanındaki değişimin %28.2’sini açıkladı. Hemşirelerde kültürel uygulamalar konusunda eğitim almanın iletişim becerileri düzeyini arttırdığı, cinsiyetin kültürel zekâ üzerinde etkili bir faktör olduğu, eğitim düzeyinin yükselmesinin kültürel zekâ düzeyini arttırdığı ve iletişim becerileri yüksek olan hemşirelerin kültürel zekâ düzeylerinin daha yüksek olduğu sonucuna varıldı.
- MakaleAçık Erişim2024Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom
Seliman, Thoiba Mogahid Hussein; Ülbegi, Gulsum Altiparmak; Ozsoy, Nurten; Kavlo, Hevidar Alp; Sagirli, Pinar Aksoy
Background and Aims: Pleurotus species are edible mushrooms with important economic and medicinal value. Many pharmacological properties of these species, such as anticancer, immunomodulating, and anti-inflammatory activities, have been attributed to lectin. The aim of this study was to purify a novel lectin from Pleurotus eryngii var. ferulae (PEFL) and investigate its anti-inflammatory activity. Methods: PEFL was purified by 80% ammonium sulphate fractionation, diethylaminoethyl (DEAE)-Sepharose-4B anion exchange, and Sephadex G-100 gel filtration chromatography. The molar mass of the purified lectin was determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under denaturing conditions. Inhibition of lectin-induced haemagglutination by several carbohydrates and one glycoprotein (ovalbumin) was also performed using the haemagglutination inhibition activity test. The anti-inflammatory effect of PEFL was tested in a lipopolysaccharide (LPS)-induced inflammation model in mouse macrophage cells (RAW 264.7). The levels of prostaglandin (PG)-E2, tumour necrosis factor-alpha (TNF-alpha), interleukin1-beta (IL-1 beta), interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma) were determined using enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was estimated by western blot analysis. Results: PEFL was obtained in 16% yield. The specific activity of PEFL was calculated as 1280 haemagglutinating units (HU)/mg protein and was inhibited only by D-galactose. The molecular weight was determined to be 46 kDa. PEFL showed an anti-inflammatory effect by reducing the production of pro-inflammatory PGs through COX-2 inhibition, as well as reducing iNOS expression. Furthermore, our findings reported that PEFL has a protective effect on inflammation by decreasing the production of pro-inflammatory cytokines and increasing the production of the anti-inflammatory cytokine (IL-10). Conclusion: The results suggest that PEFL can be considered as a potential therapeutic agent in the development of new therapeutic strategies for inflammatory diseases.
AtıfWoS1OpenAlex2
İncele - MakaleAçık Erişim2024Effect ofthe Practice of Guided Imagery on the Perceived Stress Level in High-Risk Pregnancies
Dal, Nursel Alp; Beydag, Kerime Derya; Dogan, Aysel
Objective: This research was conducted to identify the effect of the practice of Guided Imagery on the perceived stress level in high-risk pregnancies. Methods: The study was designed as a prospective, randomized, and single-blind study. The research was performed with the participation of a total of 128 women (64 in the experimental group, 64 in the control group) who had high-risk pregnancies between February-May, 2021. The data were evaluated with the Perceived Stress Scale. Results: The experimental group obtained a lower mean of post -test scores (26.36 +/- 5.96) from the Perceived Stress Scale than the control group (30.48 +/- 3.93), and this difference was statistically significant (p<.05). Also, the experimental group obtained lower mean scores from the Perceived Stress Scale in the post -test phase than the one in the pretest phase, and this difference was statistically significant (p<.05). Conclusion: Nurses and midwives should include the practice of Guided Imagery in the care processes to reduce the stress levels of women with high-risk pregnancies.
AtıfWoS1OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ2Synthesis and characterization of TiNbZrMo medium-entropy bio-composites: Microstructure, mechanical properties, and in vitro degradation
Say, Yakup
This study reports the synthesis and characterization of hydroxyapatite (HA)-based bio-composites reinforced with varying amounts (by weight, 1–15 wt.%) of bio-medium entropy alloy (BioMEA) for load-bearing implant applications. BioMEA powders consisting of Ti, Nb, Zr, and Mo were mechanically alloyed for 100 h and subsequently added to HA using powder metallurgy techniques. To show the effect of BioMEA, the microstructure, density, and mechanical tests have been conducted and the synthesized BioMEA was characterized by scanning electron microscope (SEM), x-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FTIR) analysis. In addition, in vitro degradation behavior and bioactivity analyses of bio-composites have been conducted. XRD analysis revealed the formation of BioMEA after 20 h of mechanical alloying. The highest density value of 2.47 g/cm3 was found in 15 wt.% BioMEA-reinforced bio-composite. The addition of BioMEA reinforcement led to a significant increase in hardness and tensile strength values, with the highest values observed at 15 wt.% reinforcement. Compression tests demonstrated a significant increase in compressive strength and deformation capability of the bio-composites with the highest values observed at 15 wt.% BioMEA addition. The highest toughness of 7.68 kJ/m2 was measured in 10 wt.% MEA-reinforced bio-composites. The produced bio-composite materials have an elastic modulus between 3.5–5.5 GPa, which may provide a solution to the stress shielding problems caused by the high elastic modulus of metallic implant materials. The most severe degradation occurred in 15 wt.% MEA-reinforced bio-composites, and the effect of degradation caused a decrease in Ca and an increase in Ti-Ni-Zr-Mo in all bio-composites. These findings suggest that HA/BioMEA bio-composites have the potential to be developed as advanced biomaterials with moderate mechanical and biological properties for load-bearing implant applications.
AtıfScopus2WoS1OpenAlex3
İncele - MakaleAçık Erişim2024Scopus SJRQ2Modeling the growth behavior of Salmonella spp. in grated carrots inoculated with different inoculum levels stored at various temperatures
Omac, Basri
The consumption of fresh and fresh-cut fruits and vegetables, such as carrots, has increased for the last decades for a healthy life and an adequate diet, but concerns regarding the microbial safety of them have been raised. The present study was conducted to develop predictive models for Salmonella spp. in grated carrots. The results showed that Salmonella spp. did not display growth at 5°C, but it grew in grated carrots at other temperatures (10, 15, 20, 25, and 37°C) for both inoculum levels. Also, the inoculum levels affected the growth of this pathogen in grated carrots when the storage temperatures ranged from 15 to 25°C. The theoretical minimum temperatures calculated using the Huang model were 3.48 and 5.79°C for inoculum levels of 101 and 102 CFU/g, respectively. The primary and secondary models performed well in terms of agreement between experimental and estimated values. Furthermore, compared to the Ratkowsky model, the theoretical minimum temperature was given a more reasonable value using the Huang model. The models developed in the present study will be a useful input for future quantitative microbial risk assessment to appraise the proliferation of Salmonella spp. in grated carrots throughout the production process, storage, and distribution.
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ2Genotypic diversity and antagonistic activities of enterococci isolated from pastırma
Ertekin, Özlem; Kaban, Güzin; Kaya, Mükerrem
The biodiversity of enterococci from pastırma (a traditional Turkish dry-cured meat product) by genotypic identification and the antagonistic activities of strains were investigated. Pastırma samples taken from 20 different small-scale factories were subjected to microbiological and physicochemical analysis. A hundred enterococci isolates were identified by 16S rRNA gene sequence analysis. To determine antagonistic activity of strains, Listeria monocytogenes and Staphylococcus aureus were used. The lactic acid bacteria and Micrococcus/Staphylococcus counts were ≥ 6 log cfu/g in 55% of the samples and 75% of the samples, respectively. Enterobacteriaceae was generally below the detectable level (< 2 log cfu/g). The enterococci count was higher than 6 log cfu/g in 30–35% of the samples, depending on the medium used. The enterococci isolates (100 isolates) were identified as E. faecium (80 strains), E. faecalis (19 strains) and E. hirae (1 strain) in genotypic identification. The nine E. faecium strains showed antagonistic activity against L. monocytogenes in the well diffusion test. In contrast, in the same antagonistic activity test, all of the strains had no antagonistic activity against S. aureus. Further studies could be planned to characterize E. faecium strains that show antagonistic activity against L. monocytogenes.
AtıfScopus2WoS2OpenAlex1İncele - MakaleYalnız künye2024Scopus SJRQ2Plant extract-based biosynthesis of silver nanoparticle and silver–zinc nanocomposites-doped hydroxyapatite and its antimicrobial activity
Unal, Ilkay; Aydoğdu, Burcu; Aytar, Mehmet
Hydroxyapatite (HAp) is an essential material in the biomedical field because of its chemical composition, similar to the apatites found in bones. The lack of bactericidal properties of HAp-based materials cannot prevent the adhesion and growth of bacteria. However, it can develop composite biomaterials using nanoparticles (NPs) such as silver (Ag) and zinc (Zn), which exhibit biocidal behaviours to control resistant microorganisms. This study aimed to prepareHAp–AgNPs and HAp–Ag@ZnNPs nanocomposite and evaluate their antimicrobial properties against Gram-positive and Gram-negative bacteria. HAp powders were produced from sheep bone. An aqueous extract of Marrubium astracanicum was used as a reducing and stabilising agent for the synthesis of NPs. The composites were characterized by XRD, SEM–EDX, SEM and FTIR. In vitro biocompatibility assessment was determined by agar well diffusion tests. The HAp–Ag@ZnNPs nanocomposites showed stronger antimicrobial activity than HAp–AgNPs against bacteria and fungi, while pure HAp did not show any effect.
AtıfScopus6WoS5OpenAlex4İncele - BildiriYalnız künye2024Performance Analysis of Attention Mechanisms for Melanoma Cancer Detection
Dogan, Gurkan
The deadliest type of skin cancer worldwide is melanoma. If melanoma skin cancer is detected and treated at an early stage, the mortality rate can be significantly reduced. In particular, convolutional neural networks, one of the deep learning techniques that have achieved remarkable success in recent years in areas such as computer vision, natural language processing, signal processing, etc., can detect this type of cancer automatically, quickly and with high accuracy. Moreover, the accuracy performance of the neural network can be further increased by using attention mechanisms together with convolutional neural networks. However, attention mechanisms have not been used correctly and effectively in the neural network models proposed so far for the detection of melanoma skin cancer. This study examines the effect of attention mechanisms on the accuracy performance of a convolutional neural network and guides researchers to use these mechanisms correctly and effectively. To achieve this, a base model based on a convolutional neural network was built. Then, seven different attention mechanisms were integrated separately into this basic model and the results of the experimental tests of each were presented.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ3Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications
Ak, Gunes; Tüfekci, Enis Fuat; Mustafa, Ahmed M.; Caprioli, Giovanni; Altunoglu, Yasemin Celik; Baloglu, Mehmet Cengiz; Cakılcıoglu, Ugur; Polat, Rıdvan; Darendelioglu, Ekrem; Zengin, Gokhan
Sorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S. torminalis leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS-MS. The effects of the extracts on cell viability were investigated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method against MDA-MB-231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p<0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin-3,5-diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5-dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n-hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of S. torminalis on antimicrobial, biofilm inhibitory, and anticancer activities was examined. Based on outcomes of our study recognize this plant as a critical source of medically active chemicals for feasible phytopharmaceutical and nutraceutical applications, providing the first scientific insight into the detailed biological and chemical profiles of S. torminalis.
AtıfScopus7OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ1Work stress and obsessive-compulsive symptoms in nurses and office workers: a comparative study
Kuzu Durmaz, Ayşe; Çiçekoğlu Öztürk, Pınar; Çevik Durmaz, Yadigar
Objectives. This study aims to compare the work stress and obsessive-compulsive symptoms of nurses and office workers and to determine the relationship between work stress and obsessive-compulsive symptoms. Methods. A total of 127 nurses and 127 office workers participated in the cross-sectional study and comparative study. Data were collected using the perceived work stress scale and the Maudsley obsessive-compulsive inventory. Results. Nurses had higher work stress scores (p = 0.003) in general than office workers. In particular, nurses with a low (p < 0.039) and average (p < 0.007) economic status, nurses who had been employed for 1–10 years (p < 0.001) and nurses working 40 h per week (p < 0.042) had higher work stress scores than office workers. There was no difference (p > 0.05) between obsessive-compulsive symptom scores. There was a positive significant relationship (p < 0.001) between work stress and obsessive-compulsive symptom scores of nurses and office workers. Work stress explains 6.1% of the obsessive-compulsive symptoms in nurses and 12.4% in office workers. Conclusion. The results of this study concluded that work stress of nurses is higher than that of office workers and work stress affects the obsessive-compulsive symptoms in both groups.
AtıfScopus4WoS3OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1A new hybrid mobile CNN approach for crosswalk recognition in autonomous vehicles
Doğan, Gürkan; Ergen, Burhan
While automobile transportation is increasing worldwide, it also negatively affects the safety of road users. Along with the neglect of traffic rules, pedestrians account for 22% of all highway traffic deaths. Millions of pedestrians suffer non-fatal injuries from these accidents. Most of these injuries and deaths occur at crosswalks, where the highway and pedestrians intersect. In this study, deep learning-based a new hybrid mobile CNN approaches are proposed to reduce injuries and deaths by automatically recognizing of crosswalks in autonomous vehicles. The first of these proposed approaches is the HMCNet approach, which is a hybrid model in which the MobileNetv3 and MNasNet CNN models are used together. This model achieves approximately 2% more accuracy than the peak performance of the lean used MobileNetv3 and MNasNet models. Another proposed approach is the FHMCNet approach, which increases the success of the HMCNet approach. In the FHMCNet approach, LSVC feature selection method and SVM classification method are used in addition to HMCNet. This approach increased the classification success of HMCNet by more than approximately 2%. Finally, the proposed FHMCNet offered approximately 3% more classification accuracy than state-of-the-art methods in the literature.
AtıfScopus10WoS7OpenAlex8İncele - MakaleYalnız künye2024Scopus SJRQ3Development of a novel rare earth element doped chitosan-graft-poly(hydroxyethyl methacrylate) composite for biomedical applications: synthesis, characterization, drug delivery, and antibacterial properties
Gürler, N.; Torǧut, G.; Yazdıç, F.C.; Karaman, A.; Karaaslan Ayhan, N.
The films of chitosan-graft-poly(hydroxyethyl methacrylate) polymer (Ch—g-poly(HEMA)) doped with the rare earth element (REE) lanthanum (La content of 0, 0.2, 0.4, and 0.8 wt.%) were fabricated. The films were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), thermogravimetric analysis (TGA), and powder X-ray diffraction (XRD) analysis. The films obtained were loaded with a model drug tetracycline by freezing/thawing method. The cumulative drug release properties of tetracycline were investigated. The release of tetracycline from the polymer matrix was carried out in phosphate-buffered saline (PBS) buffer (pH 7.4) at 37 °C. It was found that the REE-doped composite films had a retarding effect on tetracycline drug release compared to that of the undoped film. All tested composites regardless of the REE dopant content were found to be active against three Gram-positive and three Gram-negative bacterial strains used to assess the antimicrobial properties of the polymer composites. These findings demonstrated that lanthanum and tetracycline have a high affinity for the Ch—g-poly(HEMA) polymer and suggested a synergistic effect in the polymer—lanthanum—tetracycline system. The La3+-doped Ch—g-poly(HEMA) composite film can be used as drug carrier system in the biomedical field.
AtıfScopus4WoS4OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ3The correlation between children’s health literacy level and healthy eating self-efficacy
Kasimoğlu, Necla; Gürarslan Baş, Nazan
Background The school environment provides an important opportunity for children and educators to develop health education and health literacy the ability to make rational health decisions and identify and determine factors that affect health. The aim of this study is to determine the correlation between health literacy and eating self-efficacy levels of primary school students and the affecting factors. Methods The study was conducted with 486 fourth graders studying in a primary school located in eastern Turkey between September 2021 and June 2022. The data were collected through face-to-face interviews using the Personal Information Form, the Health Literacy for School-Age Children Scale (HLSAC), and the Healthy Eating Self-Efficacy Scale for Children (HESES-C). Data were analyzed by number, percentage, mean, independent samples t-test, non-parametric Mann–Whitney U and Kruskal–Wallis tests, and Pearson’s correlation tests. Results The gender of the students and the education level of their mothers had a statistically significant correlation with their mean HESES-C and HLSAC scores scores (p<0.05). There was a significant negative correlation between the students’ HLSAC and their HESES-C mean scores. Conclusions According to the findings of the study, the students had a moderate level of health literacy and a low level of healthy eating self-efficacy. There was a negative relationship between health literacy levels and healthy eating self-efficacy.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ4Oxidative and physiological effects of carvedilol, a beta–blocker, in Daphnia magna; [Efectos oxidativos fisiológicos del carvedilol, un betabloqueante, en Daphnia magna]
Seker, Engin
Carvedilol is a beta–blocker. Beta–blockers affect the heart and circulation. carvedilol is used to treat heart failure and hypertension. Although this substance has effects in humans and some animals, its effect on the physiological and antioxidant status of daphnids is unknown. The aim of this study was to determine the effect of carvedilol doses (0, 0.125, 0.45 and 0.90 mg·L-1) on physiological activities (heart rate, postabdominal paw activity and thoracic limb movements) and oxidative stress. In Daphnia magna; malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total glutathione (GSH) and glutathione S transferase (GST) markers were examined. The activity of physiological parameters in D. magna exposed to all carvedilol concentrations was found to be lower than in the control group, and the differences were statistically significant (P<0.01). Application of carvedilol to D. magna resulted in lower GSH content in all groups throughout the experimental period. MDA, SOD, CAT and GST activity were improved. These findings indicate that carvedilol causes physiological and biochemical changes in D. magna. Daphnia species have great potential to provide valuable insights into the mechanisms of human medicine. More comprehensive research is needed on this subject.
- MakaleYalnız künye2024Scopus SJRQ2Insight into novel inhibitors from Sterculia urens against Cholera via pharmacoinformatics and molecular dynamics simulation approaches
Rahman, M. Oliur; Ahmed, Sheikh Sunzid; Alqahtani, Ali S.; Cakilcioğlu, Uğur; Akbar, Mohammad Ahsanul
The underdeveloped countries with large populations are facing a grave global threat in the form of cholera. Vibrio cholerae, the etiologic agent of Cholera has drawn attention recently due to antimicrobial resistance and resulting outbreaks that necessitates establishment of novel medications to counteract virulence and viability of the pathogen. Sterculia urens Roxb. (Malvaceae) is an ethnomedicinally important tree, which harbors a good number of bioactive phytocompounds. In the present study, 53 phytocompounds of S. urens were screened against the promising target ToxT of V. cholerae employing structure-based drug design approach that revealed three lead compounds, viz., 4,4,5,8-Tetramethylchroman-2-ol (−8.2 kcal/mol), Beta-Bisabolol (−8.2 kcal/mol) and Ledol (−8.7 kcal/mol) with satisfactory ADMET properties. Molecular dynamics simulation for 150 ns unveiled notable compactness and structural stability for the lead compounds considering RMSD, RMSF, Rg, MolSA, PSA and protein-ligand contacts parameters. Molecular mechanics-based MM/GBSA binding energy calculation revealed Beta-Bisabolol (−66.74 kcal/mol) to have better scores than 4,4,5,8-Tetramethylchroman-2-ol (−47.42 kcal/mol) and Ledol (−65.79 kcal/mol). Enzymes were mostly found as drug target class, and Nabilone was found as a structurally similar analog for 4,4,5,8-Tetramethylchroman-2-ol. These discoveries could aid in revealing new antibacterial medications targeting ToxT to combat Cholera. Communicated by Ramaswamy H. Sarma.
AtıfScopus8OpenAlex8İncele - MakaleYalnız künye2024Scopus SJRQ2On β-titanium alloys: tailoring gamma-ray, and neutron transmission properties for nuclear and biomedical applications
Almisned, Ghada; Baykal, Duygu Sen; Alkarrani, Hessa; Güler, Ömer; Kilic, Gokhan; Mesbahi, Asghar; Tekin, Huseyin Ozan
This study explores the gamma-ray and neutron transmission properties of β-Titanium alloys pivotal for their performance in nuclear and biomedical applications. Utilizing the Monte Carlo N-Particle (MCNP 6.3) simulations, we analyzed a spectrum of Ti-based alloys modified with elements like molybdenum (Mo), zirconium (Zr), niobium (Nb), and hafnium (Hf) to determine their radiation attenuation properties. Key parameters such as mass and linear attenuation coefficients, half-value layers, exposure buildup factors, and fast neutron effective removal cross-section values were computed, revealing significant enhancements in attenuation with the addition of high-Z elements. Specifically, alloys like Ti50Hf50 and (TiZr)40Cu60 exhibited superior photon and fast neutron attenuation due to their high-Z constituents. For instance, Ti50Hf50 showed a mass attenuation coefficient of 0.217 cm2/g and a half-value layer of 2.97-cm at 0.1 MeV photon energy, while (TiZr)40Cu60 demonstrated similar performance with a mass attenuation coefficient of 0.198 cm2/g and a half-value layer of 3.26-cm. These alloys also exhibited effective neutron removal cross-section values of 0.115 cm-1 and 0.130 cm-1, respectively. Alloys with lower-Z elements showed less attenuation, which may be beneficial in scenarios requiring reduced radiographic contrast in biomedical applications. The MCNP outcomes were in strong agreement with standard data, affirming the accuracy of computational methods in predicting material behavior. In conclusion, tailored alloy development is crucial for improving radiation shielding and diagnostic visualization, with broader implications for patient safety and treatment efficacy.
AtıfScopus3OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1Novel formulations ameliorate osteoarthritis in rats by inhibiting inflammation and oxidative stress
Erten, Fusun; Ozdemir, Oguzhan; Tokmak, Muhammed; Durmus, Ali Said; Ozercan, Ibrahim Hanifi; Morde, Abhijeet; Padigaru, Muralidhara; Sahin, Kazim
The study tested new oral plant-based formulations (F) on rats with monosodium iodoacetate (MIA)-induced osteoarthritis, measuring inflammation, antioxidant levels, paw size, stride, and analyzing knee joint images. Fifty-six female Sprague Dawley rats were allocated into 8 groups: (1) Control, (2) MIA (OA induced with MIA), (3) MIA + F1 [curcuminoids+gingerols+acetyl-11-keto-β boswellic acid (AKBA)], (4) MIA + F2 (curcuminoids+Withania glycosides+AKBA), (5) MIA + F3 (curcuminoids+total withanolides+AKBA), (6) MIA + F4 (curcuminoids, AKBA), (7) MIA + UCII (type II collagen), and (8) MIA + GCHON (Glucosamine Chondroitin). Treatments F1 to F4 reduced right joint diameter and improved stride length and paw area in OA rats. Despite improvements with treatments F1 to F4, there was no significant difference between these groups (p >.05). In OA animals, F1 to F4 treatments decreased MDA levels and increased antioxidant enzymes activities (p <.001). This was done by reducing levels of inflammatory markers and enzymes like IL-1β, IL-6, MMP-8, TNF-α, CRP, COMP, and LOX-5, while increasing the anti-inflammatory cytokine IL-10. In conclusion, these plant-based treatments significantly reduced osteoarthritis severity, slowed disease progression by reducing inflammation, and protected joints from damage, showing a protective effect in rats with induced osteoarthritis, likely due to their anti-inflammatory and antioxidant properties.
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