Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2020Scopus SJRQ2Synthesis, and antimicrobial and anticancer activities of sodium acrylate copolymers
Torğut, Gülben; Pıhtılı, Güzin; Erecevit Sönmez, Pınar; Erden, Yavuz; Kırbağ, Sevda
This study was designed to synthesize poly(sodium acrylate-co-N-isopropylacrylamide) via aqueous free-radical polymerization using the 2,2′-azobisisobutyronitrile initiator system at 60°C. The structural characterization of the copolymer was determined by Fourier-transform infrared spectroscopy. The polymer was synthesized in two different ratios, namely, poly(NaAc-co-NIPA1:1) and poly(NaAc-co-NIPA2:1), to investigate whether it affects their antibacterial–antifungal activities and anti-tumour effects. When the antimicrobial activities of different proportions of the copolymer extracts prepared with pure water were examined using the agar disc diffusion sensitivity test (at 120 μL: 10.8 mg/µL), it was observed that they had effect at increasing rates against all the bacteria, yeasts and dermatophyte fungi such as Staphylococcus aureus COWAN 1, Staphylococcus cohnii ATCC 29974, Bacillus megaterium DSM 32, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae FMC 5, Pseudomonas aeruginosa DMS 50071 SCOTTA, Candida albicans FMC 17, Candida glabrata ATCC 66032, Trichophyton sp. and Epidermophyton sp. The results of this study revealed that the obtained copolymers have significant effects on the treatment of diseases. In addition, the anti-tumour activities of the poly(NaAc-co-NIPA1:1) copolymer on human breast (MCF-7) and ovarian cancer (A-2780) cell line were specified and it was determined that high doses of the copolymer showed anti-tumour effects on both types of cancer cell lines. Also, this article reviews its antimicrobial and anticancer activities that will be of help for future scientists.
AtıfScopus3WoS3OpenAlex6
İncele - MakaleAçık Erişim2020Scopus SJRQ4Investigation of curcumin role on doxorubicin-induced tissue damage in terms of trace metal levels using etaas
Ince, Olcay Kaplan; Kandemir, Fatih Mehmet; Ince, Muharrem; Benzer, Fulya; Onal, Ali; Kucukler, Sefa
Doxorubicin (DXR) is one of the commonly used chemotherapeutic agents, which is highly toxic and causes gastrointestinal and cardiac toxicity. Curcumin is used as a spice and coloring agent in food, but also possesses anti-proliferating, potent antioxidant, antitumor-promoting and anti-carcinogenic properties in vitro and in vivo. In this study, the change in element concentrations in the tissues of healthy animals was examined by administering doxorubicin and curcumin separately, or both at the same time. For this purpose, 35 wistar albino male rats were selected and randomly divided into five groups of seven each. The objective of this study was to assess and compare the levels of copper, iron, zinc and selenium in the liver, kidney, heart, and testis of the control group and in the doxorubicin-induced tissues. According to the results, the Cu, Fe, Zn, Se amounts and the Cu/Fe, Cu/Zn, and Cu/Se ratios were present at different levels in each of the five groups. In terms of element concentration, the most affected tissue by doxorubicin application is the heart, and the least affected is the kidney. The ratios of Cu/Fe and Cu/Se in the liver and the heart were highest in Group II and Group III, respectively.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2020Scopus SJRQ1Accurate deep neural network model to detect cardiac arrhythmia on more than 10,000 individual subject ECG records
Yildirim, Ozal; Talo, Muhammed; Ciaccio, Edward J.; Tan, Ru San; Acharya, U Rajendra
Background and objective: Cardiac arrhythmia, which is an abnormal heart rhythm, is a common clinical problem in cardiology. Detection of arrhythmia on an extended duration electrocardiogram (ECG) is done based on initial algorithmic software screening, with final visual validation by cardiologists. It is a time consuming and subjective process. Therefore, fully automated computer-assisted detection systems with a high degree of accuracy have an essential role in this task. In this study, we proposed an effective deep neural network (DNN) model to detect different rhythm classes from a new ECG database. Methods: Our DNN model was designed for high performance on all ECG leads. The proposed model, which included both representation learning and sequence learning tasks, showed promising results on all 12-lead inputs. Convolutional layers and sub-sampling layers were used in the representation learning phase. The sequence learning part involved a long short-term memory (LSTM) unit after representation of learning layers. Results: We performed two different class scenarios, including reduced rhythms (seven rhythm types) and merged rhythms (four rhythm types) according to the records from the database. Our trained DNN model achieved 92.24% and 96.13% accuracies for the reduced and merged rhythm classes, respectively. Conclusion: Recently, deep learning algorithms have been found to be useful because of their high performance. The main challenge is the scarcity of appropriate training and testing resources because model performance is dependent on the quality and quantity of case samples. In this study, we used a new public arrhythmia database comprising more than 10,000 records. We constructed an efficient DNN model for automated detection of arrhythmia using these records.
AtıfScopus143OpenAlex146
İncele - MakaleAçık Erişim2020Scopus SJRQ3An exhaustive review and analysis on applications of statistical forecasting in hospital emergency departments
Gul, Muhammet; Celik, Erkan
Emergency departments (EDs) provide medical treatment for a broad spectrum of illnesses and injuries to patients who arrive at all hours of the day. The quality and efficient delivery of health care in EDs are associated with a number of factors, such as patient overall length of stay (LOS) and admission, prompt ambulance diversion, quick and accurate triage, nurse and physician assessment, diagnostic and laboratory services, consultations and treatment. One of the most important ways to plan the healthcare delivery efficiently is to make forecasts of ED processes. The aim this study is thus to provide an exhaustive review for ED stakeholders interested in applying forecasting methods to their ED processes. A categorisation, analysis and interpretation of 102 papers is performed for review. This exhaustive review provides an insight for researchers and practitioners about forecasting in EDs in terms of showing current state and potential areas for future attempts.
AtıfScopus63WoS54OpenAlex80İncele - MakaleAçık Erişim2020Contribution of Polymorphism in PPARα Untranslated Region to The Development of Axial Spondyloarthritis; [PPARα Kodlanmayan Bölge Polimorfizminin Aksiyal Spondiloartrit Gelişimine Katkısı]
Akbulut, Ekrem; Özgen, Metin
The study aimed to contribute to the overall understanding of axial spondyloarthritis by investigating the polymorphism in 5’ untranslated region of peroxisome proliferator-activated receptor alpha gene in patients. The study included 194 patients and 197 controls recruited. The DNA obtained from the samples was genotyped by multiplex Polymerase Chain Reaction and then Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. Data were analyzed by logistic regression. Five polymorphic regions analyzed in this study, three of the sites were associated with disease risk. An allele in the rs1800204 polymorphic region (p < 0.001), C allele in the rs4253657 polymorphic region (p = 0.040) and C allele in the rs13909022 polymorphic region (p = 0.005) were associated with disease risk. The association of disease risk could not be detected with G and A alleles in the rs881740 (p = 0.456) and rs115640476 (p = 0.674) polymorphic regions, respectively. PPARα 5' untranslated region polymorphism, which is shown to be associated with disease risk, is thought to contribute to the elucidation of the molecular mechanism of the disease. In axial spondyloarthritis, studying the effects of genetic changes in PPARα on other genes with which it interacts will contribute to the full understanding of the molecular mechanism of the disease.
AtıfScopus1OpenAlex1İncele - MakaleYalnız künye2020Scopus SJRQ1Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study
Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Jekő, József; Cziáky, Zoltán
Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
AtıfScopus65OpenAlex64İncele - MakaleAçık Erişim2020Scopus SJRQ2The changes in semen quality, arginase activity and nitric oxide level in dexamethasone-treated rams
Ozer Kaya, Seyma; Erisir, Mine; Gur, Seyfettin; Kandemir, Fatih Mehmet; Benzer, Fulya; Kaya, Emre; Sonmez, Mustafa; Turk, Gaffari
This study was made to investigate the effects of intramuscular administrations of dexamethasone on seminal plasma nitric oxide levels and arginase activity, and some spermatological parameters in rams. Ten Akkaraman rams weighing 50–60 kg and 2 years old were used as material in this study. The study was performed during the breeding season (September–November) for rams. The semen was collected by artificial vagina at 1st, 4th, 24th, 48th, 72nd and 96th hours for control group before dexamethasone administration. For treatment group, 0.25 mg/kg dexamethasone was administered and semen was collected at the time points described for control group. Spermatological characteristics of semen samples (semen volume, pH, sperm motility, density and abnormal sperm rate), seminal plasma arginase enzyme activities and nitric oxide levels were determined. It was determined that the administration of dexamethasone was detected to decrease seminal plasma arginase activity (p <.05 and.01) and nitric oxide level (p <.05), semen volume (p <.05 and.01), mass activity (p <.05 and.01), sperm density (p <.05) and sperm motility (p <.05 and.01), and to increase abnormal sperm rate (p <.05 and.01). In conclusion, dexamethasone is not recommended to be used during the breeding season as it damages the sperm quality of the rams.
AtıfScopus10WoS7OpenAlex8İncele - MakaleAçık Erişim2020Scopus SJRQ2Salacia chinensis exerts its antidiabetic effect by modulating glucose-regulated proteins and transcription factors in high-fat diet fed-streptozotocin-induced type 2 diabetic rats
Erten, Fusun; Orhan, Cemal; Tuzcu, Mehmet; Er, Besir; Defo Deeh, Patrick Brice; Sahin, Nurhan; Özercan, Ibrahim Hanifi; Juturu, Vijaya; Sahin, Kazim
This study aimed to investigate the properties of Salacia chinensis (Celastraceae, SC) and its molecular mechanism in the type 2 diabetic rats. Forty-two Wistar rats were divided into six groups (n = 7): control, SC (100 mg/kg, per os), high-fat diet (HFD), HFD + SC (100 mg/kg), HFD + streptozotocin (STZ, 40 mg/kg, i.p.), and HFD + STZ+SC. SC decreased serum glucose, insulin, triglycerides, free fatty acid, and malondialdehyde levels, but increased serum total antioxidant capacity (0.33 ± 0.02 versus. 0.79 ± 0.03), compared with the untreated group (p <.001). Additionally, SC elevated the expression of glucose-regulated proteins GLUT2, PPAR-ɣ, p-IRS, and Nrf2, but downregulated NF-κB in the liver and kidney (p <.001). In conclusion, SC could improve insulin resistance by modulation of glucose-regulated proteins and transcription factors in diabetic rats. Practical applications: Present data has contributed to the current ethnomedicinal benefits of SC, through which the SC intake regulated the carbohydrate metabolism and increased the antioxidant capacity. The balance of transcription factors can mediate these efficacies partially and various key proteins involved in energy metabolism, along with oxidative stress and insulin sensitivity.
AtıfScopus8WoS8OpenAlex10İncele - MakaleYalnız künye2020Scopus SJRQ2A multi-method patient arrival forecasting outline for hospital emergency departments
Yucesan, Melih; Gul, Muhammet; Celik, Erkan
Patient arrivals at the emergency department (ED) of hospitals has an unpredictable behavior. So that, adequate forecasting of this process can serve a management baseline to better allocate ED human resources and medical equipment. In this paper, a multi-method patient arrival forecasting outline for EDs is developed. The methods followed within this study include single methods as linear regression (LR), autoregressive integrated moving average (ARIMA), artificial neural network (ANN), exponential smoothing and hybrid methods as ARIMA–ANN and ARIMA-LR. As the subject of the study, a private hospital ED case in Turkey is carried out. Data of ED patient arrivals for the year of 2016 was used to set up models. Forecasting performance of the multi-method outline was measured using mean absolute percentage error. The ARIMA–ANN hybrid model is shown to outperform in terms of forecasting accuracy. In order to contribute to the current knowledge, this paper is a novel attempt of applying these methods to model ED patient arrivals and making an overall assessment among them. The results can be used to aid in strategic decision-making on ED staffing and scheduling policy planning in response to predictable arrival variations.
AtıfScopus29WoS26OpenAlex37İncele - MakaleYalnız künye2020Scopus SJRQ4Quality changes and storage life of common carp (Cyprinus carpio) with the use of Ginger (Zingiber officinale) essential oil
Sönmez, Pınar Erecevi t; Kuzgun, Nermin Karaton; Kirbağ, Sevda
Ginger (Zingiber officinale) essential oil is considered safe. In this study, ginger (Zingiber officinale) essential oil was used to extend storage life of common carp (Cyprinus carpio) and detect its protective effects. The following tests were performed to assess the shelf life of carp (C:control) treated with ginger essential oil (G). The microbiota growth of the carp, sensory properties, pH, TVB TBA values, the shelf life of the carp changed positively by adding ginger oil in different concentrations to the carp (C1, C2, C3: 0.1%, 0.25%, 0.5%ginger essential oil was added to carp samples). On the other hand; ginger essential oil has a positive effect on TVB-N and TBA values of carp fillets. With reference to the results of microbiota growth, carp sample (C: control) showed the highest value (P < 0.05) on the 6th storage day. The results show the importance of the use of Zingiber officinale essential oil to prevent food spoilage.
AtıfScopus2WoS1İncele - MakaleAçık Erişim2020Scopus SJRQ4The Effect of Resveratrol on The Oxidative Stress in Rats Treated with Irradiation
Ozcelik, Mehtap; Erisir, Mine; Guler, Osman; Baykara, Murat; Bulmus, Funda Gulcu
The antioxidant and protective effect of resveratrol against irradiation induced oxidative damage were researched. Twenty-one rats were seperated into 3 groups; First group was the control group. Second group was the irradiation group; received physiological saline intraperitoneally (i.p.) for three days, then 9 Gray (Gy) irradiation was applied. Third group was irradiation+Resveratrol group; received 10 mg/kg resveratrol i.p. for three days and then the same dose of radiation was applied. As a result of irradiation, a significant increase was found in the level of malondialdehyde (MDA) in the liver, kidney and brain tissues of rats (P<0.001). Glutathione peroxidase (GSH-Px) activity in all the tissues and superoxide dismutase (SOD) activity, Glutathione (GSH) levels in liver decreased (P<0.01), GSH levels in kidney, spleen and ovarium tissues significantly increased (P<0.05). The giving of resveratrol significantly reduced the MDA levels increasing in liver, kidney, and brain as a result of irradiation (P<0.001) and the liver MDA levels reached to the control levels. By giving resveratrol, it was determined that all the antioxidants studied reduced significantly compared to the control group and/or the irradiation group (P<0.05). According to the data obtained as a result; It was concluded that resveratrol shows a corrective effect by changing the oxidant/antioxidant balance against oxidative stress caused by irradiation, therefore resveratrol is a powerful antioxidant.
AtıfScopus2OpenAlex3
İncele - MakaleYalnız künye2020Scopus SJRQ3Inhibitory effect of Tunceli garlic (Allium tuncelianum) on blastocystis subtype 3 grown in vitro
Aykur, Mehmet; Karakavuk, Emrah; Karakavuk, Muhammet; Akıl, Mesut; Can, Hüseyin; Döşkaya, Mert; Gürüz, Yüksel; Dağcı, Hande
Objective: Blastocystis is a common protozoan parasite detected worldwide. This study aims to investigate the in vitro inhibitory effect of ethyl alcohol extracts of Tunceli garlic (Allium tuncelianum) on growth of Blastocystis ST3 subtype. Methods: Blastocystis ST3 were grown in 3 ml Jones’s medium containing A. tuncelianum prepared at five different concentrations for 72 hours at 37°C. Distilled water was used as negative control whereas metronidazole (MTZ) and trimethoprim-sulfamethoxazole (TMP-SMX) prepared in 0.1, 0.5 and 1 mg/ml of concentrations was used as the positive control. Results: According to the results, the MIC90 of the A. tuncelianum was 115 mg/ml at 72 hours. MIC90 of MTZ was 1 mg/ml at 72 hours (94.96%). TMP-SMX had the highest growth MIC90 effect which was reached at 1 mg/ml concentration during 24 hours (88.18%). The growth inhibitory effect of A. tuncelianum extract increased gradually in all doses and timepoints. Conclusion: In this study, obtained findings show the potential inhibitory effect of A. tuncelianum plant extract against Blastocystis ST3 which causes symptomatic diarrhea in humans. It may be recommended to consume the whole A. tuncelianum plant as food supplement. A. tuncelianum extract could be considered as an alternative for the potential treatment of Blastocystis infection.
AtıfScopus6OpenAlex7İncele - MakaleYalnız künye2020Scopus SJRQ3A fuzzy-based occupational health and safety risk assessment framework and a case study in an international port authority
Gul, Muhammet
Ports are complex systems that play a crucial role in the transportation of maritime-related products and services. Since ports face various safety issues in design, installation, operation and maintenance processes, there are many aspects open for improvement in Occupational Health and Safety risk assessment and it is required to deal with risks, reduce them to an acceptable level and control. To struggle with emerging risks and manage this process better, a risk assessment framework is proposed for ports in this study. A case study is performed in a Turkish international port authority using the proposed framework. Fuzzy Analytic Hierarchy Process (FAHP), which is a commonly used fuzzy multi-criteria decision-making method, was used in weighting two risk factors: likelihood and severity. The orders of priority of hazards were then determined by a fuzzy-based VIKOR method based on the output of FAHP. The proposed framework overcomes some drawbacks, including a lack of assignment on the weight to two risk assessment factors and lack of the high dependence of the prioritisation on the experts’ opinions. To validate the results, a sensitivity analysis was conducted. In conclusion, the study contributes to the applicability of the proposed framework to assess the risks in ports and provides a distinct risk prioritisation.
AtıfScopus43WoS39OpenAlex49İncele - MakaleYalnız künye2020Scopus SJRQ1Evaluating occupational health and safety service quality by SERVQUAL: a field survey study
Demir, Pelin; Gul, Muhammet; Guneri, Ali Fuat
The adverse impact of occupational accidents and occupational diseases on the society have recently increased a lot since the industrial-oriented society is getting more and more widespread. Although attempts regarding occupational health and safety (OHS) increase in Turkey, they are still at an inadequate level. OHS experts prepare employees for a healthy and safer working environment, so that work accidents can be eliminated and employees can be healthy psychologically and physically. At the same time, the worksites can be prevented from being financially damaged and productivity can be improved. The aim of this study is to measure OHS service quality by the evaluations of OHS experts from various sectors and workplaces. In this way, the OHS performance is measured, the difference between perceptions and expectations of the OHS experts is determined and deficiencies are revealed. In the study, the OHS activities are examined in five dimensions using the SERVQUAL scale; tangibility, reliability, responsiveness, assurance and empathy. The questionnaire is carried out using a Likert-type five-point scale among 81 OHS experts from different sectors. In conclusion, SERVQUAL analysis is introduced as a useful tool for employers to better understand what they need to know about OHS services.
AtıfScopus20WoS15OpenAlex26İncele - MakaleAçık Erişim2019Isparta’da Yetişen Bazı Elma Çeşitlerinin Meyve Eti, Kabuk ve Çekirdek Yuvasındaki Antioksidan Kapasitesinin Belirlenmesi
Çimen, Murat; Benzer, Fulya; Yıldırım, Mahsum; Barış, Dilan; Yıldırım, Hüseyin; Karaca Sanyürek, Nesrin; Karakavuk, Emrah
Bu çalışmada Isparta ili Eğirdir ilçesinden temin edilen beş farklı elma çeşidinde meyve eti, kabuk ve çekirdek yuvasındaki antioksidan kapasiteleri ABTS, DPPH ve TFM yöntemleri kullanılarak belirlenmiştir. Analiz sonuçları incelendiğinde çeşitler, alınan kısımlar ve yöntemler bakımından antioksidan seviyelerinin farklılık gösterdiği görülmüştür. En yüksek antioksidan aktivite ‘Granny Smith’ çeşidinde bulunmuştur. En düşük antioksidan aktivite ise ‘Pink Lady’ çeşidinde tespit edilmiştir. Meyve eti, kabuk ve çekirdek yuvasındaki antioksidan miktarları sırasıyla %29.93, %21.95, %27.22 olarak tespit edilirken, TFM metodu ile yapılan analizlerde antioksidan miktarı ABTS ve DPPH metotlarına göre daha yüksek bulunmuştur.
AtıfOpenAlex6TR Dizin4İncele - MakaleAçık Erişim2019Entaurea kurdica Reichardt and Centaurea urvillei DC. subsp. hayekiana Wagenitz’nın Element İçeriği ve Antioksidan Enzimlerinin Belirlenmesi
Çakılcıoğlu, Uğur; Uruç Parlak, Kadriye
Kronik hastalıklar dünya çapında hızla artmaktadır. Tüm yaşam boyunca sağlığın iyileştirilmesi ve sürdürülmesinde beslenme ve diyet önemli bir yere sahiptir. Organizmadaki biyokimyasal ve fizyolojik değişim, biyomoleküllerde oksidatif hasara yol açan serbest radikallerin aşırı artmasına neden olabilir. Son zamanlarda tıbbi bitkilerin kullanımı antioksidanlar, antikanser ve hipoglisemik aktiviteler gibi yararlı özellikler nedeniyle artmıştır. Bu çalışmada kullanılan, Centaurea kurdica Reichardt ve Centaurea urvillei DC. subsp. hayekiana Wagenitz (Asteraceae) Elazığ'ın çeşitli bölgelerinde doğal olarak yetişen endemik türlerdir. Centaurea'nın birçok taksonu geleneksel olarak hem ülkemizde hem de dünyada tıbbi amaçlarla ve besinler için kullanılmaktadır. Centaurea kurdica Reichardt ve Centaurea urvillei DC. subsp. hayekiana Wagenitz (Asteraceae) taksonları Elazığ'daki doğal yaşam alanlarından elde edilmiştir. Bitki dokularında ağır metal akümülasyonu, antioksidan enzimler süperoksit dismutaz (SOD), glutatyon S transferaz (GST), askorbat peroksidaz (AP) ve katalaz (CAT) aktiviteleri gibi fizyolojik değişiklikler tespit edilmiştir. Çalışılan enzimlerden SOD en fazla aktiviteye sahip olan enzimdir. Yapılan çalışma sonucunda en fazla akümülasyonun genellikle yapraklarda olduğu tespit edilmiştir. Antioksidan enzim aktiviteleri: süperoksit dismutaz (SOD), glutatyon S transferaz (GST), askorbat peroksidaz (APX) ve katalaz (CAT) değerlendirildi Centaurea kurdica'da sırasıyla 1.315, 0.011, 0.031 ve 0.007 unit mg-1 olarak tespit edildi. C. kurdica'nın Centaurea urvillei DC. subsp. hayekiana’dan askorbat peroksidaz dışında değerlendirilen tüm enzim aktivitelerinde daha iyi olduğu belirlenmiştir.
AtıfOpenAlex4İncele - MakaleAçık Erişim2019Game, Environment and Peer Effect on Children on the Digital Gaming Habits in Game Arcades
Turgut, Yiğit Emrah; Yılmaz, Turkan Karakuş; Aslan, Alper
Game arcades that have turned into an important socialization area forchildren in Turkey, can affect children in many ways. The aim of thestudy is to investigate the factors that affect the digital game habits ofchildren and young people in game arcades. In this context, the effect ofgame, environment and peers on the habits of children that are gamingin game arcades were investigated. Qualitative research method waspreferred in the study. The study group consisted of 50 male and 2female participants randomly selected from four game arcades. Semistructured interview form was developed as a data collection tool andindividual interviews were conducted with the children participatingin the research. The findings show that children prefer digital gamesbecause they find it amusing, fun, enjoyable and exciting. Togetherwith the changing game structure, it has emerged that multi-playeronline games affect the usage of game arcades of children. Childrenstated that they prefer to play in game arcades because they can be withtheir friends and there is no parental supervision. It was determinedthat children knew these environments through their friends andwould not prefer these environments without their friends. Based onthese findings, it was concluded that multi-player online games had aneffect on the habits of children on using game arcades due to its facilityof socialization with friends and playing without any restrictions.
AtıfOpenAlex13TR Dizin5İncele - MakaleAçık Erişim2019Hemşirelik ve ebelik öğrencilerinin algılanan bakım davranışları ve empati eğilimleri
Önder, Eylem Yalçınkaya; Polat, Hilal Türkben; Serin, Emine Kaplan; Durmaz, Yadigar Çevik
Bu çalışma hemşirelik ve ebelik öğrencilerinin bakım davranışlarını ve empatik eğilimlerini belirlemeyi amaçlamaktadır. Çalışmaya 252 öğrenci (188 hemşirelik, 64 ebelik) katılmıştır. Bu çalışmaya katılan öğrencilerin çoğunu bayanlar oluşturmaktadır (201 kız, 51 erkek). Bu çalışmada very toplama aracı olarak ‘SosyoDemografik Anket Formu’, ‘Bakım Değerlendirme Anketi (Care-Q)’ ve ‘Empatik Eğilim Ölçeği’ uygulanmıştır. Veriler; betimleyici istatistikler, Kruskal Wallis testive Mann-Whitney U testi kullanılarak analiz edilmiştir. Sonuçlar, kız ve erkek öğrenciler arasında empati eğilimleri açısından anlamlı bir fark olmadığını göstermiştir. Ayrıca, hemşirelik öğrencilerinin empati eğilimlerinin ebelik bölümünde okuyan öğrencilere göre daha yüksek olmasına rağmen, hemşirelik ve ebelik öğrencileri arasında empati eğilimleri açısından anlamlı bir fark bulunamamıştır. Mesleğini isteyerek ve istemeden seçen öğrencilerin empati eğilimleri arasında anlamlı bir fark bulunmuştur. Beklendiği üzere, mesleklerini isteyerek seçenlerin empati eğilimi istekli olmayanlardan daha yüksek çıkmıştır. Öğrencilerin empati eğilimlerinin sınıf seviyelerine göre değişip değişmediği de incelenmiştir. 2.-3. sınıf, 3.-4. Sınıf ve 2.-4. Sınıf öğrencilerinin empati eğilimler iarasında anlamlı bir fark bulunamamıştır. Ancak, 2. Sınıf öğrencilerinin empati eğiliminin diğerlerinden daha yüksek olduğu dikkat çekmektedir. Kız ve erkek öğrenciler arasında her bir bakım davranışı algısı alt grubu ve toplam bakım davranışı (Care-Q/Bakım-Q) puanları açısından anlamlı bir fark bulunamamıştır. Öte yandan, hemşirelik ve ebelik öğrencileri arasında toplam Care-Q/Bakım-Q puanları bakımından hemşirelik öğrencilerinin lehine anlamlı bir fark bulunmuştur. Ek olarak, bakım davranışı ölçeğinin ‘ulaşılabilirlik’ ve ‘açıklamalar ve olanaklar’ alt boyutlarında hemşirelik ve ebelik öğrencileri arasında hemşirelik öğrencileri lehine anlamlı bir fark bulunmuştur. Öğrencilerin kariyer tercihlerine göre bakım davranış algıları arasında anlamlı bir fark bulunmamıştır. Diğer bir deyişle, öğrencilerin okudukları bölümleri isteyerek ya da rastgele seçmelerinin (kariyer tercihleri) bakım değerlendirme davranışları üzerinde hiçbir etkisi olmamıştır. Ayrıca, öğrencilerin bakım davranış algıları sınıf seviyelerine göre incelenmiş ve 2.-3. sınıf ile 3.-4. Sınıf öğrencileri arasında Care-Q/Bakım-Q testinin ‘ulaşılabilirlik’ alt boyutu açısından anlamlı bir fark tespit edilmiştir.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2019Masere sarımsak (Allium sativum Limne) ve Tunceli sarımsağı (Allium tuncelianum Kollman) yağlarının yoğun stoklanmış gökkuşağı alabalıklarının (Oncorhynchus mykiss W.) bazı kan parametrelerine ve NBT (Nitroblue Tetrazolium) seviyelerine etkileri
Aksu, Önder; Altınterim, Başar
Bu çalışmada, % 2 oranında masere sarımsak (Allium sativum L.) ve Tunceli sarımsağı(Allium tuncelianum Koll.) yağları, ortalama ağırlıkları: 39.0 ± 1.64 gr. olan gökkuşağıalabalıklarının yemlerine ilave edilmiştir. Çalışmanın sonunda, gökkuşağıalabalıklarının kan parametreleri ve NBT (Nitroblue Tetrazolium) seviyeleri tespitedilmiştir. Sarımsak uygulaması yapılan gruplarda, MCH, P-LCR, PCT, PLT ve MPVparametrelerinde kontrol ve stres gruplarına göre istatistiksel olarak farklılıkbulunmuştur (P<0.05). WBC, LYM, MID, RBC, HGB, HCT, MCV, MCHC, RDW-SD,RDW-CV ve PDW, değerleri arasında bir farklılık görülmemiştir (P> 0.05). Sarımsakuygulamaları sonucu NBT seviyeleri önemli derecede azalma göstermiştir (P<0.05). Budurum sarımsağın hücrelerdeki oksidatif stresi azalttığını göstermektedir.
AtıfOpenAlex8TR Dizin5İncele - BildiriYalnız künye2019Pneumonia Detection from Radiography Images using Convolutional Neural Networks
Talo, Muhammed
Pneumonia continues to be the leading cause of child mortality in children under the age of five, and 2,400 children, most of whom are babies under 2 years of age, die from pneumonia. In this study, an automated detection system is proposed for the diagnosis of pneumonia with chest radiography images. With the transfer learning technique, ResNet-152 convolutional neural network was customized to recognize pneumonia from radiography images. With this customized architecture, a recognition success of 97.4% was obtained in the detection of pneumonia disease without any preprocessing of raw data or manual feature extraction on radiography images. This model, which was proposed for the detection of pneumonia, found to be more successful when compared with the other successful studies in the literature.
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