Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2019Scopus SJRQ3Antifungal and antibacterial effect of dodder (Cuscuta campestris) used for hepatitis treatment of mothers and newborn infants in Province Mardin in Turkey; [Türkiye'de Mardin ilindeki annelerin ve yenidoğan bebeklerin sarılık tedavisinde kullanılan küsküt'ün (Cuscuta campestris) antifungal ve antibakteriyel etkileri]
Erecevit Sönmez, Pınar; Kirbağ, Sevda; İnci, Şule
Dodder is a plant used for the hepatitis treatment in new born infants in and around Mardin. The aim of this research to determine the antifungal and antibacterial effects of traditionally used dooder is known as a regional folk remedy. Thus and so, the efficacy of the drug has been demonstrated by the inclusion of natural therapeutic antimicrobial agents such as anti-inflammatory and wound healing, including infectious diseases. The antimicrobial effects of these plant was analyzed against bacteria, yeast and dermatopyta fungi by the agar disc diffusion method. The nominal concentration of the plant to prevent from the development of microorganisms was detected with the broth microdulitions method. It was determined that it had sensitive and moderately sensitive antimicrobial effect against all of microrganisms (13-19.66 mm/inhibition zone), growth of tested microrganisms were inhibited at 50-6.25 µL.It is though that this natural herbal resource can light the way for treatment of several diseases and direct the next studies because of having the potential for being used as a new antimicrobial agent.
AtıfScopus7OpenAlex8TR Dizin5
İncele - MakaleAçık Erişim2019Scopus SJRQ1Convolutional neural networks for multi-class brain disease detection using MRI images
Talo, Muhammed; Yildirim, Ozal; Baloglu, Ulas Baran; Aydin, Galip; Acharya, U Rajendra
The brain disorders may cause loss of some critical functions such as thinking, speech, and movement. So, the early detection of brain diseases may help to get the timely best treatment. One of the conventional methods used to diagnose these disorders is the magnetic resonance imaging (MRI) technique. Manual diagnosis of brain abnormalities is time-consuming and difficult to perceive the minute changes in the MRI images, especially in the early stages of abnormalities. Proper selection of the features and classifiers to obtain the highest performance is a challenging task. Hence, deep learning models have been widely used for medical image analysis over the past few years. In this study, we have employed the AlexNet, Vgg-16, ResNet-18, ResNet-34, and ResNet-50 pre-trained models to automatically classify MR images in to normal, cerebrovascular, neoplastic, degenerative, and inflammatory diseases classes. We have also compared their classification performance with pre-trained models, which are the state-of-art architectures. We have obtained the best classification accuracy of 95.23% ± 0.6 with the ResNet-50 model among the five pre-trained models. Our model is ready to be tested with huge MRI images of brain abnormalities. The outcome of the model will also help the clinicians to validate their findings after manual reading of the MRI images.
AtıfScopus276OpenAlex301
İncele - MakaleYalnız künye2019Scopus SJRQ3Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats
Aksu, Emrah Hicazi; Kandemir, Fatih Mehmet; Yıldırım, Serkan; Küçükler, Sefa; Dörtbudak, Muhammed Baheeddin; Çağlayan, Cüneyt; Benzer, Fulya
This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity.
AtıfScopus56WoS51OpenAlex68İncele - MakaleAçık Erişim2019Scopus SJRQ3Effect of the organophosphate insecticide chlorpyrifos exposure on oxidative stress and quality of Salmo coruhensis spermatozoa
Kutluyer, Filiz; Kocabaş, Mehmet; Erişir, Mine; Benzer, Fulya
The use of pesticides has been increasing along with increasing farming activities and has caused deleterious environmental impacts. Non-target organisms in particular, including fish, are affected by pesticides. In this work, the impacts of Chlorpyrifos (CPF) on sperm oxidative stress markers and sperm motility were investigated in vitro. CPF concentrations were 0 μg/L (control), 5 μg/L, 10 μg/L and 15 μg/L. Lipid peroxidation [malondialdehyde (MDA)], nonenzymatic antioxidants [glutathione (GSH)] and enzymatic [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] activities in sperm cells were examined for the determination of oxidative stress status. Our findings showed that motility and survival of sperm cells significantly decreased with exposure to Chlorpyrifos. Biochemical assays revealed that CAT activity and levels of MDA and, GSH increased in spermatozoa based on CPF concentration while activity of GSH-Px and SOD decreased. Consequently, spermatozoa were highly sensitive to CPF exposure. It can be deduced that CPF has the potential to disrupt sperm quality and to cause to oxidative stress in sperm cells of S. coruhensis.
AtıfScopus15WoS14OpenAlex13İncele - MakaleAçık Erişim2019Scopus SJRQ3Correlation between smartphone addiction and dysfunctional attitudes in nursing/midwifery students
Serin, Emine Kaplan; Durmaz, Yadigar Çevik; Polat, Hilal Türkmen
Purpose: The aim of this study is to determine the correlation between smartphone addiction and dysfunctional attitudes. Design and Methods: This descriptive study was conducted with the students of Nursing/Midwifery Department of a state university from March 01 to April 01, 2018. Findings: Participant students had a mean score of 27.25 ± 11.41 in smartphone addiction scale and a mean score of 27.96 ± 14.74 in dysfunctional attitudes scale. The number of students' friends was found to affect their problem solving skills. Loneliness levels of participant students affected their dysfunctional attitude scores. Practice Implications: It is highly important for our country to have sufficient knowledge of smartphone addiction, detect the dysfunctional attitudes and develop nursing care methods.
AtıfScopus11WoS10OpenAlex14İncele - MakaleAçık Erişim2019Scopus SJRQ3Examining sexual functions of women before and after menopause in Turkey
Yağmur, Yurdagül; Orhan, İlksen
Background: Sexuality is an important factor that completes the lives of individuals and affects people in all age groups. Objectives: To examine the sexual functions of women before and after menopause. Methods: This cross-sectional study was conducted at the Family Health Centers in Tunceli Turkey,\ between September 2014 and February 2015. The study data were obtained using a Questionnaire and the Female Sexual Function Index. The data were analyzed by number, percentage distribution, mean, standard deviation, t-test, and using binary logistic regression analysis. Results: The mean Female Sexual Function Index score of the women was 23.8±8.0. The Female Sexual Function Index score of 59.7% of women was below the cut-off score (26.55) and was accepted indicative of sexual dysfunction. Low educational level (P < 0.01), low income (P < 0.01), and menopausal status (P < 0.0001) of the women were risk factors for sexual dysfunction. Conclusion: Prevalence of sexual dysfunction in the women was very high and they indicated no effort to seek medical care. Low educational and income level and menopausal status of the women were three factors increasing the risk of sexual dysfunction. Awareness of the society and the healthcare professionals about the issue should be increased.
AtıfScopus18WoS18OpenAlex19İncele - MakaleAçık Erişim2019Scopus SJRQ1Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Diuzheva, Alina; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João
Several species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucheri (SA), Smyrniopsis munzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (α-amylase, α-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase's inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyl- and butyrylcholinesterase, respectively). The extracts showed higher inhibition against α-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to α-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigatus growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.
AtıfScopus51OpenAlex47İncele - MakaleAçık Erişim2019Scopus SJRQ3The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats
Ozcelik, Mehtap; Erişir, Mine; Guler, Osman; Baykara, Murat; Kirman, Esra
The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/ kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P ˂ 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P ˂ 0.01), liver SOD (superoxide dismutase) activity decreased (P ˂ 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P ˂ 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P ˂ 0.01), it did not return the increased MDA levels in the liver tissue to normal (P ˂ 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P ˂ 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P ˂ 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.
AtıfScopus8OpenAlex9İncele - MakaleYalnız künye2019Scopus SJRQ1Lactose hydrolysis and protein fortification pose an increased risk for the formation of Maillard reaction products in UHT treated milk products
Aktağ, Işıl Gürsul; Hamzalıoğlu, Aytül; Gökmen, Vural
This study aimed to survey the content of Maillard reaction products in different UHT-treated milk products and to assess how formation of these products and lysine blockage is affected by the composition. For this purpose, different commercial UHT milks including milk (whole, semi-skimmed and skimmed), lactose-hydrolyzed, protein-fortified, lactose-hydrolyzed protein fortified and follow-on infant milks were analyzed. Among the Maillard reaction products, dicarbonyl compounds, 5-hydroxymethylfurfural, furosine, N-ε-carboxymethyllysine and N-ε-carboxyethyllysine were monitored. The results showed that fortification of UHT milks with protein and carbohydrates as well as hydrolysis of lactose promoted the Maillard reaction. Among the dicarbonyl compounds, 3-deoxyglucosone formation, which was the dominant dicarbonyl compound in milks, varied between 3.12–12.67 mg/L, 13.45–21.98 mg/L and 4.59–40.38 mg/L in lactose hydrolyzed, lactose-hydrolyzed protein-fortified and follow-on infant milks whereas it was 0.22-0.40 mg/L in milks, respectively. Similarly, 5-hydroxymethylfurfural could not be detected in milks, whereas mean 5-hydroxymethylfurfural concentration was found to be 56.3 mg/L and 31.5 mg/L in protein-fortified milks and lactose-hydrolyzed protein-fortified milks, respectively. Accordingly, % blocked lysine, furosine, N-ε-carboxymethyllysine and N-ε-carboxyethyllysine content of different UHT milks were found to be significantly higher than milks (p < 0.05). This is the first study reporting the Maillard reaction products in protein-fortified and infant milks.
AtıfScopus55WoS51OpenAlex54İncele - MakaleAçık Erişim2019Scopus SJRQ2Paenidigyamycin A, potent antiparasitic imidazole alkaloid from the ghanaian Paenibacillus sp. De2Sh
Osei, Enoch; Kwain, Samuel; Mawuli, Gilbert Tetevi; Anang, Abraham Kwabena; Owusu, Kofi Baffour-Awuah; Camas, Mustafa; Camas, Anil Sazak; Ohashi, Mitsuko; Alexandru-Crivac, Cristina-Nicoleta; Deng, Hai
A new alkaloid paenidigyamycin A (1) was obtained from the novel Ghanaian Paenibacillus sp. isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Ghana. Compound 1 was isolated on HPLC at tR = 37.0 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against L. major, 1 (IC50 0.75 µM) was just as effective as amphotericin B (IC50 0.31 µM). Against L. donovani, 1 (IC50 7.02 µM) was twenty-two times less active than amphotericin B (IC50 0.32 µM), reinforcing the unique effectiveness of 1 against L. major. For T. brucei brucei, 1 (IC50 0.78 µM) was ten times more active than the laboratory standard Coptis japonica (IC50 8.20 µM). The IC50 of 9.08 µM for 1 against P. falciparum 3d7 compared to artesunate (IC50 36 nM) was not strong, but this result suggests the possibility of using the paenidigyamycin scaffold for the development of potent antimalarial drugs. Against cercariae, 1 showed high anticercaricidal activity compared to artesunate. The minimal lethal concentration (MLC) and minimal effective concentration (MEC) of the compound were 25 and 6.25 µM, respectively, while artesunate was needed in higher quantities to produce such results. However, 1 (IC50 > 100 µM) was not active against T. mobilensis.
AtıfScopus32OpenAlex32İncele - Kitap BölümüYalnız künye2019Scopus SJRQ2TRAIL Mediated Signaling in Breast Cancer: Awakening Guardian Angel to Induce Apoptosis and Overcome Drug Resistance
Yin, Ning; Yi, Liu; Khalid, Sumbul; Ozbey, Ulku; Uteuliev, Yerzhan Sabitaliyevich; Farooqi, Ammad Ahmad; Ahmad, A
Sequencing technologies have allowed us to characterize highly heterogeneous molecular landscape of breast cancer with unprecedented details. Tremendous breakthroughs have been made in unraveling contributory role of signaling pathways in breast cancer development and progression. It is becoming progressively more understandable that deregulation of spatio-temporally controlled pathways underlie development of resistance against different drugs. TRAIL mediated signaling has attracted considerable appreciation because of its characteristically unique ability to target cancer cells while leaving normal cells intact. Discovery of TRAIL was considered as a paradigm shift in molecular oncology because of its conspicuous ability to selectively target cancer cells. There was an exponential growth in the number of high-quality reports which highlighted cancer targeting ability of TRAIL and scientists worked on the development of TRAIL-based therapeutics and death receptor targeting agonistic antibodies to treat cancer. However, later studies challenged simplistic view related to tumor targeting ability of TRAIL. Detailed mechanistic insights revealed that overexpression of anti-apoptotic proteins, inactivation of pro-apoptotic proteins and downregulation of death receptors were instrumental in impairing apoptosis in cancer cells. Therefore researchers started to give attention to identification of methodologies and strategies to overcome the stumbling blocks associated with TRAIL-based therapeutics. Subsequent studies gave us a clear picture of signaling cascade of TRAIL and how deregulation of different proteins abrogated apoptosis. In this chapter we have attempted to provide an overview of the TRAIL induced signaling, list of proteins frequently deregulated and modern approaches to strategically restore apoptosis in TRAIL–resistant breast cancers.
AtıfScopus6WoS7OpenAlex7İncele - MakaleYayıncıda açık erişim2019Scopus SJRQ2Evaluation of pharmacological activity of heterobimetallic coordination compounds containing n, n-bis (2-hydroxyethyl)-ethylenediamine on ht29, hela, c6 and vero cells
Aydin, Ali; Korkmaz, Şengül Aslan
The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2 ][Ni(CN)4 ] (C1), [Cu2 (N-bishydeten)2 Co(CN)6 ].3H2 O (C2), and K[Cd(N-bishydeten)Co(CN)6 ].1.5H2 O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration and human topoisomerase I and to interact with DNA/BSA; this paper also evaluates the potential mechanisms of action exhibited by these compounds via the use of powerful measurement techniques. Studies on HT29, HeLa, C6 and Vero cells revealed that each compound demonstrated significant antiproliferative activity in conjunction with regressed cell migration velocity and caused apoptotic changes in morphology. There are strong data suggesting that the mechanisms of action exhibited by these compounds are associated with their DNA/BSA binding features. The IC50 and binding constant range for the compounds are 20-180 µM and 1.2-3.2 x 104 M-1, respectively. Moreover, we observed that these compounds alter the P53-Bcl-2 ratio and inhibit the relaxation activity of human topoisomerase I. Furthermore, a correlation between the antiproliferative effects of these compounds and their cytotoxic activity was observed. In conclusion, preliminary information demonstrates that these compounds have been found to exhibit effective antiproliferative activity against cancer cell lines, indicating that they are a potent candidate for further pharmacological study.
AtıfScopus5WoS5OpenAlex3İncele - MakaleAçık Erişim2019Scopus SJRQ2Automated detection of diabetic subject using pre-trained 2D-CNN models with frequency spectrum images extracted from heart rate signals
Yildirim, Ozal; Talo, Muhammed; Ay, B.; Baloglu, Ulas Baran; Aydin, G.; Acharya, U. Rajendra
In this study, a deep-transfer learning approach is proposed for the automated diagnosis of diabetes mellitus (DM), using heart rate (HR) signals obtained from electrocardiogram (ECG) data. Recent progress in deep learning has contributed significantly to improvement in the quality of healthcare. In order for deep learning models to perform well, large datasets are required for training. However, a difficulty in the biomedical field is the lack of clinical data with expert annotation. A recent, commonly implemented technique to train deep learning models using small datasets is to transfer the weighting, developed from a large dataset, to the current model. This deep learning transfer strategy is generally employed for two-dimensional signals. Herein, the weighting of models pre-trained using two-dimensional large image data was applied to one-dimensional HR signals. The one-dimensional HR signals were then converted into frequency spectrum images, which were utilized for application to well-known pre-trained models, specifically: AlexNet, VggNet, ResNet, and DenseNet. The DenseNet pre-trained model yielded the highest classification average accuracy of 97.62%, and sensitivity of 100%, to detect DM subjects via HR signal recordings. In the future, we intend to further test this developed model by utilizing additional data along with cloud-based storage to diagnose DM via heart signal analysis.
AtıfScopus145OpenAlex152İncele - MakaleAçık Erişim2019Scopus SJRQ2A deep learning model for automated sleep stages classification using PSG signals
Yildirim, Ozal; Baloglu, Ulas Baran; Acharya, U Rajendra
Sleep disorder is a symptom of many neurological diseases that may significantly affect the quality of daily life. Traditional methods are time-consuming and involve the manual scoring of polysomnogram (PSG) signals obtained in a laboratory environment. However, the automated monitoring of sleep stages can help detect neurological disorders accurately as well. In this study, a flexible deep learning model is proposed using raw PSG signals. A one-dimensional convolutional neural network (1D-CNN) is developed using electroencephalogram (EEG) and electrooculogram (EOG) signals for the classification of sleep stages. The performance of the system is evaluated using two public databases (sleep-edf and sleep-edfx). The developed model yielded the highest accuracies of 98.06%, 94.64%, 92.36%, 91.22%, and 91.00% for two to six sleep classes, respectively, using the sleep-edf database. Further, the proposed model obtained the highest accuracies of 97.62%, 94.34%, 92.33%, 90.98%, and 89.54%, respectively for the same two to six sleep classes using the sleep-edfx dataset. The developed deep learning model is ready for clinical usage, and can be tested with big PSG data.
AtıfScopus255OpenAlex265İncele - MakaleAçık Erişim2019Scopus SJRQ2Automated Depression Detection Using Deep Representation and Sequence Learning with EEG Signals
Ay, Betul; Yildirim, Ozal; Talo, Muhammed; Baloglu, Ulas Baran; Aydin, Galip; Puthankattil, Subha D.; Acharya, U. Rajendra
Depression affects large number of people across the world today and it is considered as the global problem. It is a mood disorder which can be detected using electroencephalogram (EEG) signals. The manual detection of depression by analyzing the EEG signals requires lot of experience, tedious and time consuming. Hence, a fully automated depression diagnosis system developed using EEG signals will help the clinicians. Therefore, we propose a deep hybrid model developed using convolutional neural network (CNN) and long-short term memory (LSTM) architectures to detect depression using EEG signals. In the deep model, temporal properties of the signals are learned with CNN layers and the sequence learning process is provided through the LSTM layers. In this work, we have used EEG signals obtained from left and right hemispheres of the brain. Our work has provided 99.12% and 97.66% classification accuracies for the right and left hemisphere EEG signals respectively. Hence, we can conclude that the developed CNN-LSTM model is accurate and fast in detecting the depression using EEG signals. It can be employed in psychiatry wards of the hospitals to detect the depression using EEG signals accurately and thus aid the psychiatrists.
AtıfScopus279OpenAlex291İncele - MakaleYalnız künye2019Scopus SJRQ2Evaluation of health risks from exposure to arsenic and heavy metals through consumption of ten fish species
Varol, Memet; Kaya, Gülderen Kurt; Sünbül, Muhammet Raşit
In this study, the levels of 11 heavy metal(loid)s (HMs) were determined in ten different fish species (wild, farmed, freshwater, and marine) frequently consumed in Turkey and compared with the maximum permissible limits (MPLs) established by international standards. Also, human health risks for the consumers were assessed. Among 11 HMs, only Al and Cr levels did not show significant differences among fish species. The highest concentrations of As were found in red mullet, which is a demersal fish. The average concentrations of Cd, Cr, Cu, and Pb in all fish species were below the MPLs, whereas those of Zn in European anchovy and Mediterranean horse mackerel, and that of inorganic As in red mullet exceeded the MPLs. The highest and lowest toxic metal contents (Al, As, Cd, and Pb) were recorded in red mullet and farmed rainbow trout, respectively. The estimated daily intakes of HMs in each fish species were very lower than their corresponding tolerable daily intakes, suggesting the daily intake of HMs through fish consumption would not pose health risks for the consumers. The target hazard quotient for individual HMs and hazard index for combined HMs in fish species were below 1, which indicated that non-carcinogenic health effects are not expected. The carcinogenic risk results revealed that there was a carcinogenic risk from exposure to inorganic As via the consumption of red mullet. Among all investigated fish species, rainbow trout and common carp were safer in terms of both non-carcinogenic and carcinogenic risks from exposure to HMs.
AtıfScopus72WoS63OpenAlex82İncele - MakaleAçık Erişim2019Scopus SJRQ3Optimization of medical waste routing problem: The case of TRB1 region in Turkey
Mete, Suleyman; Serin, Faruk
A fundamental problem concerning medical waste disposal is the evaluation of the real and potential risks arising from waste with the focus on the risk of infection. Therefore, the optimization of medical waste routing from collection to disposal center can minimize the risk of infection. The routing of medical waste considers significant to determine potential routes and select the route with minimum distance. The management of the medical waste is important decision for environmental sustainability and includes the collection, transportation and disposal of these materials. In this paper, a geographic information system (GIS) solution approach is proposed to determine the best location of disposal center. Proposed approach is applied to medical waste transportation between 167 health institutions (collection centers) and predetermined 5 disposal centers through TRB1 region in Turkey, which consist of Malatya, Elazığ, Bingöl and Tunceli provinces. The results of case study are examined and suggestions for future research are provided.
AtıfScopus7OpenAlex7İncele - MakaleAçık Erişim2018Scopus SJRQ4The Effect of Naringenin on Oxidative Stress in Some Tissues (Heart, Lung, Brain, Spleen, Muscle) of Lead-treated Rats
Benzer, Fulya; Dağ, Üzeyir; Erişir, Mine; Özkaya, Ahmet
Naringenin, a flavonoid increases resistance against oxidative stress. The present study aims to investigate the effect of lead on lipid peroxidasyonu and some antioxidants in heart, lung, brain, spleen, muscle and the effect of naringenin on these parameters. Naringenin was administered by orogastric gavage (50 mg/kg, dissolved in corn oil) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. In the rats exposed to lead, MDA levels in the brain, lungs, spleen and muscle tissues significantly increased (P<0.001), in the heart tended to increase but not significantly (P>0.05). Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P<0.05). The administration of alone naringenin caused a statistically significant decrease in MDA levels in the heart and muscle, but a significant increase in the lung (P<0.05). Although increased MDA levels in the heart, lungs, brain, muscle and spleen tissues were significantly decreased by use of the naringenin together with lead (P<0.05), increased MDA levels in the lungs and spleen tissues could not be recovered to the normal level. Generally the decreased GSH-Px and CAT activities in these tissues due to lead were significanly increased by naringenin supplementation (P<0.05). In addition, the reduced GSH levels in lung and muscle, the inceased GSH levels in heart with effect of lead were returned to the normal by naringenin. Lead particularly causes to an increase in lipid peroxidation by consuming antioxidants of cells. Naringenin was able to prevent as tissue-specific (brain, muscle) the oxidative stress caused by lead.
AtıfOpenAlex2TR Dizin2İncele - MakaleAçık Erişim20181965 Erzurum (Tekman, Cat, Ilıca, Hınıs) Measles Outbreak
Zengin, Ersoy; Küçükuğurlu, Murat
Studies on epidemic diseases in Turkey's recent history show that measles and the damage done by this disease are not adequately covered. As can be seen in the example of Erzurum, the disease, which caused massive child deaths in the late Ottoman period, did not come to an end in the first years of the Republic, but as late as 1965, especially in the southern provinces of Erzurum, hundreds of children had died. In February and March 1965, measles outbreaks in Erzurum's Tekman, Çat, Hınıs and Ilıca districts resulted in the deaths of hundreds of children in a short time. There was a violent winter in Erzurum that year; roads were closed due to snow and food and medicare aid was not available for weeks. At the time of this catastrophe, the reasons for measles disease and the remedies for the disease were discussed in national and local newspapers. There were discussions on various administrative and social issues such as malnutrition, which is called "hidden hunger", lack of health services, lack of child care knowledge, bureaucratic insensitivity, lack of transportation and communication possibilities. When studies on infectious and epidemic diseases are examined; the devastation caused by the measles disease in the Turkish society has not been adequately addressed. In this article; how the 1965 measles outbreak, which resulted in death of nearly 300 children, occurred, the helping efforts, the causes of death, and the impact on the society will be investigated.
- MakaleAçık Erişim2018Tunceli İlindeki Trafik Kazası Oranlarının İncelenmesi
Zengin, Bilgin; Arslannur, Bircan
Bu çalışmada, Tunceli ilinde 2012 - 2016 yılları arasında meydana gelen trafik kazası sayıları ile bu kazalardaki ölü ve yaralı sayıları incelenmiş, sonuçlar Türkiye oranlarıyla karşılaştırılmıştır. İncelenen yıllarda araç başına düşen kaza, ölüm ve yaralı yüzdelik oranları belirlenmiştir. Anlamlı bir değerlendirme yapabilmek için yüzdelik oranların ortalamaları dikkatlice hesaplanmıştır. Ayrıca incelenen yıllar için Tunceli ilinin ve Türkiye’nin kişi başına düşen araç sayıları belirlenmiş ve sonraki analizler için ortalamaları hesaplanmıştır. Buradan Türkiye’de kişi başına düşen araç sayısının Tunceli ili ortalamasından 2.83 kat büyük olduğu belirlenmiştir. Bu durumun aksine araç başına düşen kaza yüzdelik ortalamalarına bakıldığında ise; Tunceli ili oranının Türkiye geneli oranından 2.33 kat daha büyük olduğu görülmektedir. Buna paralel olarak, araç başına düşen ölü ve yaralı yüzdelik oran ortalamalarının da Türkiye geneli ortalamalarından sırasıyla 2.67 ve 2.77 kat daha büyük olduğu görülmüştür. Diğer yandan, Tunceli ilinde kişi başına düşen araç sayısının Türkiye ortalamasından çok düşük olmasına rağmen kaza, ölüm ve yaralı oranlarının büyük oluşunun nedenleri de araç cinsi bakımından incelenmiştir. Bu açıdan bakıldığında, Tunceli ili ve Türkiye için toplu taşıma (otobüs + minibüs) araçlarının genel araç toplamı yüzdelerinin sırasıyla %9.94 ve %3.45 olduğu hesaplanmıştır. Buradan Tunceli ilinin toplu taşıma araçları oranının Türkiye geneli oranından 2.88 kat daha büyük olduğu görülmektedir. Bu değerler bize Tunceli ilindeki trafik kazalarının toplu taşıma araçları ile yapılma olasılığının daha büyük olduğunu göstermektedir. Böylece, elde ettiğimiz bu veriler Tunceli ilindeki kazalarda ölü ve yaralı oranlarının Türkiye ortalamasından yaklaşık 3 kat büyük olması durumunu açıklamaktadır.
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