Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleYalnız künye2025Scopus SJRQ2Effects of Teach-Back intervention on teachers’ epilepsy knowledge, attitudes, self-efficacy, and first aid practices
Gürçayır, Dilek; Karabulut, Neziha; Söylemez, Nilgün
Purpose: This study investigates not only the impact of first aid training but also how the Teach-Back method influences teachers’ overall epilepsy knowledge, attitudes toward epilepsy, and self-efficacy in managing epileptic seizures. Methods: A total of 166 preschool teachers who filled out the questionnaire form and gave their consent were included in the study between April and June 2022. A quasiexperimental single-group pre-test post-test design was used in the study, Data were collected using the questionnaire form, Epilepsy Knowledge Scale, Childhood Epilepsy Attitude Scale and General Self-Efficacy Scale. The research data were collected by the researchers through face-to-face interviews. Results: It was determined that the rate of correct answers given by preschool teachers to most questions about first aid practices in epileptic seizures increased significantly after the training (p < 0.05). There was a significant improvement in preschool teachers’ first aid practices at the end of the training compared to before the training. The mean score of the Epilepsy Knowledge Scale before the training was 11.16 ± 4.04, after the training was 14.59 ± 2.08, and the difference was statistically significant (p < 0.001). The mean Childhood Epilepsy Attitude Scale score before the training was 47.90 ± 4.02, after the training was 51.53 ± 4.55, and the difference was statistically significant (p < 0.001). Conclusion: Epilepsy education significantly improved teachers’ knowledge and attitudes towards childhood epilepsy. However, the increase in general self-efficacy remained limited. This situation reveals the necessity of practical and long-term programs in addition to theoretical education.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleAçık Erişim2025Scopus SJRQ2Hybrid CNN-Transformer Model for Accurate Impacted Tooth Detection in Panoramic Radiographs
Küçük, Deniz Bora; Imak, Andaç; Özçelik, Salih Taha Alperen; Çelebi, Adalet; Türkoğlu, Muammer; Sengur, Abdulkadir; Koundal, Deepika
Background/Objectives: The integration of digital imaging technologies in dentistry has revolutionized diagnostic and treatment practices, with panoramic radiographs playing a crucial role in detecting impacted teeth. Manual interpretation of these images is time consuming and error prone, highlighting the need for automated, accurate solutions. This study proposes an artificial intelligence (AI)-based model for detecting impacted teeth in panoramic radiographs, aiming to enhance accuracy and reliability. Methods: The proposed model combines YOLO (You Only Look Once) and RT-DETR (Real-Time Detection Transformer) models to leverage their strengths in real-time object detection and learning long-range dependencies, respectively. The integration is further optimized with the Weighted Boxes Fusion (WBF) algorithm, where WBF parameters are tuned using Bayesian optimization. A dataset of 407 labeled panoramic radiographs was used to evaluate the model’s performance. Results: The model achieved a mean average precision (mAP) of 98.3% and an F1 score of 96%, significantly outperforming individual models and other combinations. The results were expressed through key performance metrics, such as mAP and F1 scores, which highlight the model’s balance between precision and recall. Visual and numerical analyses demonstrated superior performance, with enhanced sensitivity and minimized false positive rates. Conclusions: This study presents a scalable and reliable AI-based solution for detecting impacted teeth in panoramic radiographs, offering substantial improvements in diagnostic accuracy and efficiency. The proposed model has potential for widespread application in clinical dentistry, reducing manual workload and error rates. Future research will focus on expanding the dataset and further refining the model’s generalizability.
AtıfScopus36OpenAlex34İncele - MakaleAçık Erişim2025Scopus SJRQ4Protective Effect of Sumac and Terebinth Extracts Against the Negative Effects of Breast Cancer on Cardiac Tissues of in Rats; [Efecto protector de los extractos de zumaque y terebinto contra los efectos negativos del cáncer de mama en los tejidos cardíacos de ratas]
Erişir, Figen Erdem; Aydın, Sevinç; Tuzcu, Zeynep; Yılmaz, Ökkeş
Due to the toxic side effects of chemotherapeutic drugs used in breast cancer, interest in medicinal plants has increased in order to develop alternative cancer drugs. The experimental model of this study was created to observe the remedial impacts of the Terebinth (Pistacia terebinthus L.) and the Sumac (Rhus coriaria L.) plants against the negative effects of 7,12-Dimethylbenz[a]anthracene induced breast cancer on cardiac tissues in rats. For this purpose, the levels of malondialdehyde were analyzed the indicator of the oxidative stress breast cancer will cause on cardiac tissues, the catalase, glutathione transferase and superoxide dismutase enzymes, glutathione, which holds and important place among antioxidant impacts and proteins. At the end of the study, it was determined that there was an increase in malondialdehyde levels, a decrease in glutathione and protein amounts, and a decrease in antioxidant enzyme levels in rats treated with cancer-induced 7,12-Dimethylbenz[a]anthracene.
- MakaleAçık Erişim2025Scopus SJRQ2Localization of phoenixin-14 and nesfatin-1, known as pleiotropic peptides, in some central and peripheral organs of female and male rats
Esen, Engin; Parlak Ak, Tuba; Yaman, Mine
Neuropeptides are diverse neuronal signaling molecules that regulate cellular and physiological functions. Phoenixin (PNX) and Nucleobindin 2 (NUCB2)/nesfatin-1, which are known to co-localize and interact in some hypothalamic nuclei such as arcuate nucleus (ARC) and paraventricular nucleus (PVN), have important pleiotropic roles. The aim of this study was to investigate the immunohistochemical distribution of these neuropeptides in biological tissues of adult female and male rats. For this purpose, a total of 12 Spraque-Dawley rats, 6 female and 6 male, aged 3–4 months, were sacrificed and hypothalamus, pituitary, brain, cerebellum, adrenal gland, ovary and testis tissues were taken. Serum gonadotropin-releasing hormone (GnRH), plasma PNX-14, and NUCB2/nesfatin-1 concentrations showed no statistically differences between sexes. PNX-14 immunoreactivity was more prominent in the ARC of male rats, whereas NUCB2/nesfatin-1 immunoreactivity was markedly higher in the PVN of females. In the anterior pituitary, PNX-14 and NUCB2/nesfatin-1 staining was more intense in females relative to males. PNX-14 immunoreactivity in the brain was quite high in female and male rats, and this immunoreactivity in the cerebellum was low in both sexes. NUCB2/nesfatin-1 exhibited moderate immunoreactivity in these organs in both sexes. In the adrenal cortex of both sexes, PNX-14 immunoreactivity was quite intense, while NUCB2/nesfatin-1 was a moderate intensity. PNX-14 immunoreactivity was more intense in the ovary, whereas NUCB2/nesfatin-1 immunoreactivity was more prominent in the testis. In conclusion, we demonstrated the immunohistochemical localization of PNX-14 and NUCB2/nesfatin-1 neuropeptides, in conjunction with serum GnRH levels, in organs associated with the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes of adult male and female rats.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Nursing Students' Attitudes Towards Clinical Practice and Occupational Risk Perceptions
Daşbilek, Ferhat; Yeşiltepe, Akgün; Erçel, Şeyda
Aims and Objectives: In this study, it was aimed to determine nursing students' attitudes towards clinical practice and their perceptions of occupational risk. Method: The research is descriptive and cross-sectional. The population of this study consisted of second-, third- and fourth-year students studying in the Department of Nursing affiliated to the Faculty of Health Sciences of a university located in Turkey. The analysis was conducted using JASP 0.19.1.0 and SPSS 25 software. Mann–Whitney U and Kruskal–Wallis tests were applied. The Bonferroni test was performed to identify the group causing the difference. Results: A significant positive correlation was found between nursing students' perception of occupational risk and nursing students' attitude toward clinical practice (r = 0.434, p = 0.000). The mean score of the nursing students' perception of occupational risk in nursing students was 68.74 ± 15.04. The mean score of attitude towards clinical practice in nursing students was 100.04 ± 24.83. A statistically significant difference was found between the presence of attitude towards clinical practice in nursing students and perception of occupational risk in nursing students in the gender variable (p < 0.05), whereas a statistically significant difference was found between adequate information about the nursing profession and attitude towards clinical practice in nursing students (p < 0.05). Conclusion: In the findings of the study, nursing students' perception of occupational risk and attitudes towards clinical practice were found at a high level. A statistically significant difference was found between the presence of perception of occupational risk in nursing students and attitude towards clinical practice in nursing students in the gender variable. In addition, a statistically significant difference was found between adequate knowledge and nursing profession about the nursing profession and attitude towards clinical practice in nursing students.
AtıfOpenAlex1İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2COVID-19 Alters Respiratory Function Associations in High-Level Athletes
Kabak, Banu; Erdoğan, Murat; Tortu, Erkan; Deliceoğlu, Gökhan; Bulgay, Celal; Kızar, Oktay; Baydaş, Giyasettin; Szabo, Attila
Background and Objectives: Coronavirus disease 2019 (COVID-19) has affected multiple physiological systems, including respiratory function, which is critical for athletic performance. Although alterations in pulmonary dynamics have been observed in high-level athletes recovering from COVID-19, the effects on respiratory function remain unclear. In this context, the present study aimed to examine the impact of COVID-19 on the interrelationships among respiratory function parameters in high-level athletes. Materials and Methods: Sixty-eight high-level athletes participated in the present study, including 34 with a history of COVID-19 and 34 controls without prior infection. Respiratory function and respiratory muscle strength were assessed using a digital spirometer (Pony FX, Cosmed, Italy). Key variables included Forced Vital Capacity (FVC), Peak Expiratory Flow (PEF), Maximum Voluntary Ventilation (MVV), Forced Expiratory Volume in one second (FEV1), and Maximum Inspiratory/Expiratory Pressure (MIP/MEP). Results: High-level athletes with prior COVID-19 infection exhibited significant differences in the correlations (p < 0.05) between FVC and PEF, FVC and MVV, FEV1 and FEV1/FVC, and MIP and MVV compared to controls. Conclusions: These findings suggest that COVID-19 can disrupt the interrelationships among respiratory function parameters in high-level athletes, highlighting the need for further longitudinal investigations.
AtıfScopus1OpenAlex1İncele - MakaleYalnız künye2025Scopus SJRQ2Evaluation of Nano-Zinc Borate Effects on Thermal Properties, Morphology, Antibacterial Activity, and Drug Release Behavior of Starch/Gelatin Hydrogel Films for Biomedical Applications
Koçak, Berna; Gürler, Nedim; İpek, Yeliz; Yazdıç, Ferit Can; Karaman, Altuğ
Starch and gelatin offer opportunities for use due to their non-toxicity, biocompatibility, physical and functional properties. In this study, different amounts of nano-zinc borate were added to starch/gelatin composition for biological applications and their properties were studied. The structure of the films was investigated by various techniques. Nanostructured zinc borate was synthesized using a chemical method and particle sizes were determined as 196 nm. The atenolol drug was doped into the polymer composite. The atenolol release was performed at pH 7.4 and in phosphate-buffered saline solution medium. Cumulative drug release was 76% with the inclusion of nano-zinc borate in the polymer mixture. The atenolol release was approximately 50%–70% in films with nano-zinc borate added after 300 min. Furthermore, thermal resistance of the films improved with the addition of nano-zinc borate. The investigated chemical compound exhibited pronounced antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), with significantly greater potency compared to Gram-negative bacteria (E. coli and Pseudomonas aeruginosa). Notably, the formulation containing 1.5% starch, 0.5% gelatin, and 1% nano-zinc borate demonstrated broad-spectrum efficacy against all tested pathogens, highlighting its potential as a promising antibacterial agent. The observed differential activity against bacterial strains suggests that fine-tuning the concentrations of starch, gelatin, and nano-zinc borate may optimize antibacterial efficacy and broaden the spectrum. The results showed us that non-toxic and biocompatible polymer films can be realized in pharmaceutical industry systems and biomedical applications.
- MakaleAçık Erişim2025Scopus SJRQ1The Mediating Role of Physical Literacy in the Relationship Between e-Health Literacy and a Sustainable Healthy Lifestyle Among Adolescents
Akarsu, Mehmet; Güllü, Mehmet; Günata, Gül Polat; Kızılkaya, Aysel; Aydın, Savaş; Özcan, Ecesu; Norman, Göktuğ; Kurhan, Cihad Onur
Background: It is well-established that, for adolescents to adopt sustainable healthy lifestyle behaviors, not only access to information but also the skills required to translate that information into action are critical. In this field, research that examines the relationship between e-health literacy and sustainable healthy lifestyle behaviors within the context of physical literacy is notably scarce. In this context, the aim of this study is to examine the effect of e-health literacy on a sustainable healthy lifestyle and to evaluate the mediating role of physical literacy in this relationship. Methods: A total of 835 adolescents from high schools across Türkiye voluntarily participated in this study. During the data collection process, the e-Health Literacy Scale, the Perceived Physical Literacy Scale, and the Healthy and Sustainable Lifestyle Scale were utilized. Data were analyzed using the JASP (version 0.18.3.0) software. Correlation analysis and structural equation modeling were conducted, and the bootstrap method (n = 5000) was employed for mediation analysis. Results: The effect of e-health literacy on a sustainable healthy lifestyle was found to be positive and statistically significant (β = 0.452, p < 0.001). Similarly, e-health literacy significantly predicted physical literacy (β = 0.755, p < 0.001), and physical literacy significantly predicted a sustainable healthy lifestyle (β = 0.310, p < 0.001). The mediating effect was also statistically significant (β = 0.234, p < 0.001). The model explained 32% of the variance in healthy lifestyle behaviors. Conclusions: The findings indicate that evaluating e-health literacy and physical literacy together provides a holistic approach to fostering sustainable healthy lifestyle habits among adolescents. It is recommended that intervention programs be structured to encompass both areas of competence.
AtıfScopus4OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ3Bioactive Compounds and Antioxidant Properties of Mucus from Freshwater Snails Viviparus contectus and Planorbis rubrum
Kocabaş, Filiz Kutluyer; Kocabaş, Mehmet; Kızak, Volkan; Korkmaz, Büşra; Benzer, Fulya; Erişir, Mine
Abstract: As a viscous-elastic substance, snail mucus has a great attention in the medical and cosmetic industries in recent years due to contain many bioactive compounds. Freshwater snails are cosmopolite aquatic invertebrates and distribute nearly all types of inland aquatic bodies due to their adaptive abilities, rapid growth and short life cycles and, the compounds of mucus derived from freshwater snails has not been well documented. Hence, this study focused on identification bio-active ingredients and determination of protein content and antioxidant enzyme activities in freshwater snails Viviparus contectus and Planorbis rubrum mucus. Bioactive constituents of mucus in freshwater snails were characterized by Gas Chromatography-Mass Spectrometry (GC-FID-MS) analysis. Antioxidants (GSH, SOD, CAT and GSH-Px) and protein content were assessed in freshwater snails. Our data revealed that thirteen compounds are characterized with nonadecanoic acid methyl ester (11.57%), nonadecane (5.01%) and heptadecanoic acid methyl ester (4.19%) as the main components of P. rubrum mucus while eleven compounds are characterized with farnesol (11.23%), 5-hydroxymethyl-1,1,4α-Trimethyl-6-methylene-decahydronphthalen-2-ol (9.73%), kaur-16-en-18-oic acid methyl ester (9.64%), tricosane (9.62%), and kaurene (8.44%) as the main components of V. contectus mucus. Nonadecanoic acid methyl ester and nonadecane, known as effective bioactive constituents having antimutagenic and antitumor capability, were determined with 11.57 and 5.01% of the total bio-active composition of P. rubrum mucus, respectively. As a major constituent, farnesol was detected with 11.23% of the total bio-active composition of V. contectus mucus. Moreover, the presence of kaurene, known as a potent bioactive compound for cancer treatment, in notably quantity in V. contectus mucus. In addition, GSH levels and SOD, CAT, and GPx activities was highest level in P. rubrum compared to V. contectus. Protein content was highest level in V. contectus than P. rubrum. Overall, individual compounds of V. contectus and P. rubrum mucus could be isolated and purified and used for the treatment of a variety of human ailments.
- MakaleAçık Erişim2025Scopus SJRQ1One-pot synthesis of quercetin-functionalized silver and copper nanoparticles for enhanced optical, antimicrobial, and computational properties
Aziz, Dara Muhammed; Amin, Alla Ahmed Muhammed; Hassan, Sangar Ali; Özmen, Habibe; INCILI, Gökhan Kursad; Say, Yakup
The emergence of multidrug-resistant bacterial strains has intensified the need for novel antimicrobial agents. Herein, we report a facile one-pot green synthesis of quercetin-stabilized silver (Qn@AgNPs) and copper (Qn@CuNPs) nanoparticles using quercetin as both reductant and capping ligand. The resulting nanocomposites were fully characterized by UV–Vis spectroscopy (surface plasmon resonance peaks at 420 nm for Ag and 580 nm for Cu), FTIR (confirming quercetin–metal coordination), SEM/EDX (spherical particles, and XRD (face-centered cubic Ag and Cu phases). Density functional theory (B3LYP/3-21G) calculations yielded frontier molecular orbital gaps of 0.164 eV for Qn@AgNPs and 0.245 eV for Qn@CuNPs, with corresponding high softness values (12.20 and 8.16 eV⁻¹), indicating enhanced electron-transfer propensity. Molecular electrostatic potential maps revealed increased charge polarization around the metal centers. Antibacterial assays against Escherichia coli and Staphylococcus aureus demonstrated minimum inhibitory concentrations of 2.11 ± 1.22 µg/mL and 4.69 ± 2.68 µg/mL for Qn@AgNPs, and 7.50 ± 0.00 µg/mL and 6.25 ± 0.17 µg/mL for Qn@CuNPs, significantly outperforming free quercetin (188 and 375 µg/mL). In silico docking against the S. epidermidis TcaR regulator (PDB: 1KZN) and E. coli DNA gyrase B (PDB: 1HSK) revealed strong binding affinities (–7.54 to − 10.15 kcal·mol⁻¹), consistent with the observed antimicrobial potency. This integrated experimental–computational study elucidates the mechanistic underpinnings of quercetin-mediated nanoparticle bioactivity and provides a rational framework for designing next-generation flavonoid-functionalized metal nanotherapeutics.
AtıfScopus12WoS11OpenAlex14İncele - MakaleYalnız künye2025Scopus SJRQ2Enhanced gastrointestinal disease classification using a convvit hybrid model on endoscopic images
Utku, Anıl
Endoscopy is a procedure that allows examination of the gastrointestinal system, including the stomach, esophagus, large intestine, and duodenum, with the help of an endoscope. Processing of endoscopic images is important for early detection and treatment of gastrointestinal diseases. In this study, hybrid ConvViT was developed using CNN and ViT to increase the classification accuracy of pathologies in gastrointestinal endoscopic images. CNNs are well-suited for capturing local spatial features through hierarchical convolutions, making them highly effective in detecting fine-grained textures and edge patterns. These capabilities complement the ViT’s global attention mechanism, which excels at modeling long-range dependencies in images. The motivation of this study is to increase the classification accuracy and reliability with the ConvViT model, which was developed by combining the practical features of CNN and ViT models, which are individually successful in different aspects of image processing. The ConvViT model was compared with VGG-16, ResNet-50, Inception-V3 and ViT. Comparable models were tested using a gastrointestinal endoscopic image dataset containing ulcers, polyps, inflammation, bleeding, and regular anatomical features. Experiments showed that ConvViT had better prediction performance than compared models, with 95.87% classification accuracy.
AtıfScopus5WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ3The Level of Intimate Partner Violence Against Women, Contributing Factors, and its Effects on Psychological Resilience: An Evaluation of Women in Turkey
Orhan, İ.; Ünal, E.; Ağralı, C.; Küçükkelepçe, D.Ş.
Background: Violence by intimate partners is a serious public health problem that negatively affects women’s physical, emotional, and social well-being. In Turkey, factors such as traditional gender roles, economic inequalities, and cultural norms contribute to the continuation of this form of violence. Understanding how such experiences influence women’s psychological strength is essential for effective support and prevention strategies. Aim: This study aims to determine the relationship between domestic violence against women, the factors affecting it, and levels of psychological resilience among women in Turkey. Patients and Methods: We conducted this research with 425 women residing in Tunceli, Turkey. In this cross-sectional, relational study, data were collected using a personal information form, the Violence Against Women Scale (SVAWS), and the Brief Resilience Scale (BRS). The relationship between scores obtained from the scales was determined through correlation and linear regression analyses. Cronbach’s alpha coefficient was calculated to assess the reliability of the scales. Results: The average age of the women who participated in the study was 41.22 ± 12.93 years. Approximately one in four women (24.5%) experienced violence, with the primary reasons for violence being financial problems (40.4%) and issues caused by family members of the couple (28.8%). A significant negative correlation was found between the SVAWS and BRS scores (r = −0.228, P < 0.01). Additionally, there was a significant negative relationship between all subdimensions of the violence scale and psychological resilience. Conclusion: The study found that as the level of violence experienced by women increased, their level of psychological resilience decreased.
- MakaleAçık Erişim2025Scopus SJRQ4Is There a Difference Between Postpartum Depression and Mother-baby Bonding in Pregnant Women Who Had and Did Not Have COVID-19? A Comparative and Cross-sectional Study; [COVID-19 Geçiren ve Geçirmeyen Gebelerde Doğum Sonrası Depresyon ve Anne-bebek Bağlanması Arasında Fark Var mıdır? Karşılaştırmalı ve Kesitsel Bir Çalışma]
Karatay, Gülnaz; Gürarslan Baş, Nazan; Yüksekol, Aslı
Objective: This study was conducted to examine the effect of being diagnosed with coronavirus disease-2019 (COVID-19) during pregnancy on postpartum depressive symptoms and infant-mother bonding. Method: This comparative cross-sectional study was conducted in a city in southeastern Turkey. Using the purposeful sampling method, 210 postpartum women (106 had COVID during pregnancy, 104 did not) constituted the sample of the study. The data were collected through face-to-face interviews between 15 March and 30 May 2022. Data were collected using the mother introductory information form, mother-infant bonding scale, and Edinburgh postnatal depression scale. The obtained data were analyzed using percentages, means, t-test, chi-square, Mann-Whitney U, and regression analysis. Results: According to the findings of the study, a significant relationship has been observed between contracting COVID-19 and both the birth weight of the baby and the week of birth. Moreover, having COVID-19 negatively affected infant-mother bonding and increased postpartum depressive symptoms. Conclusion: According to the findings of the study: it was observed that the babies of mothers who had COVID-19 had lower birth weight, were born before the full term, mother-baby bonding was lower, and postpartum depression was higher in mothers.
- MakaleAçık Erişim2025Scopus SJRQ1Effect of neuro-linguistic programming on comfort after cesarean: a randomized controlled trial neuro-linguistic programming comfort level cesarean
Doğan, Aysel; Dal, Nursel Alp; Beydag, Kerime Derya
Background: Due to the deterioration in comfort experienced after cesarean section, mothers go through troubled hours, have problems with breastfeeding, and cannot even meet their own and their baby’s needs. This study was conducted to determine the effect of neuro-linguistic programming on mothers’ comfort levels following cesarean section in the postpartum period. Methods: This study was performed from 1 January to 1 September 2023 as a prospective randomized controlled single-blind clinical trial with 100 participants (50 experimental, 50 control). The research data were collected using the Personal Information Form and the Postpartum Comfort Scale. The dependent samples t test and independent samples t test were used in the analysis of research data as well as numbers, percentages, and means. Analysis of covariance (ANCOVA) was used to evaluate the effect of the NLP more accurately by controlling the pre-test scores. Results: There were statistically significant differences between the mean pretest and posttest postpartum comfort scale scores, physical comfort scores, psycho-spiritual comfort scores, and sociocultural comfort scores of mothers in the intervention group. In this regard, mothers in the intervention group had higher mean postpartum comfort scale scores, physical comfort scores, psycho-spiritual comfort scores, and sociocultural comfort scores in the posttest phase than in the pretest phase. Conclusions: This study revealed that neuro-linguistic programming enhanced the postpartum comfort levels of mothers who underwent cesarean delivery. In this context, it is recommended that nurses and midwives enhance participants’ comfort through the use of neuro-linguistic programming techniques in care processes. Trial registration: NCT05646537.
AtıfScopus3WoS2OpenAlex2İncele - Derleme MakaleYalnız künye2025Scopus SJRQ2Revolutionizing biomedicine with rare earth element nanoparticles: physical properties and biotechnological potential
Şahal, Hakan
Rare earth elements (REEs) are used in the creation of many promising technologies that have the potential to revolutionize many medical and biotechnological fields such as medical imaging, cancer treatment and diagnosis, biosensors and diagnostic kits, tissue engineering and regenerative medicine, cosmetics and dermatology, gene therapy and molecular biology, pharmacology, and drug delivery systems today and in the future. Their use as targeted treatment approaches, biocompatible materials and imaging agents with anticancer, antimicrobial, antibacterial, and antioxidant properties enables revolutionary developments in modern medicine and biotechnology. The versatile uses of these elements may contribute to the development of more effective and sensitive methods in medical treatment and diagnosis in the future. For this reason, they are intensively researched worldwide. The focus of this research is that rare earth elements and their derivatives can provide innovative solutions for diagnosis and treatment at the molecular level. Doping with rare earth elements, which are considered as vitamins of industries, redefines the properties of materials and increases their efficiency. For this reason, research is aimed at obtaining new properties and applications by creating hybrid structures of rare earth elements with different components. In recent years, scientific interest in investigating the molecular interactions of REEs with biomolecules has increased. These studies aim to activate drug-specific molecules in target cells, reduce their side effects, and provide more effective treatment methods. These studies aim to create potential structures in gene therapy, biosensor technologies, and cancer research with modifications performed using REEs. This study investigates the transformative potential of REE nanoparticles in various biotechnological and biomedical applications and emphasizes their promise as versatile tools for innovation in multiple disciplines by highlighting their roles in advancing targeted therapies, reducing side effects and addressing critical challenges in modern healthcare.
AtıfScopus2WoS1OpenAlex2İncele - MakaleYalnız künye2025Scopus SJRQ2Highly sensitive DNA-based electrochemical biosensor for analysis of oseltamivir used in treatment of COVID–19
Keçeci, Ali; Koçak, Berna; İpek, Yeliz
Promising clinical results were obtained in the treatment of coronavirus disease by using favipiravir, umifenovir, remdesivir, ribavirin, lopinavir–ritonavir, oseltamivir, etc., antiviral drug active agents. In this study, quantitative analysis of oseltamivir neuraminidase inhibitor was carried out using electrochemical techniques. DNA-based electrochemical biosensors are generally used for analysis of anticancer and antitumor medicines. The present study introduces a novel DNA-based electrochemical sensor for neuraminidase inhibitor drug oseltamivir. The developed sensor enables the analysis of oseltamivir in a more environmentally friendly, more economical and faster way. It can be used in quality control laboratories in tablet production and will provide traceability of the drug in drug development studies and analysis in urine samples. For this purpose, a modified glassy carbon electrode was used as a working electrode. The glassy carbon electrodes alone cannot detect the oseltamivir. Guanine base, which was determined to interact with oseltamivir and found in the deoxyribonucleic acid structure, was used as an electrochemical biosensor agent. The guanine base was immobilized on glassy carbon electrode using glutardialdehyde as a crosslinker material and GA2–Guanine/GCE electrode was achieved. Two working ranges were determined for the Britton-Robinson buffer solution, tablet sample, and urine sample containing oseltamivir. The lowest detection limits (LODs) were calculated as 7.16 × 10−9 mol L−1, 9.05 × 10−9 mol L−1 and 6.19 × 10−6 mol L−1 for Britton-Robinson buffer solution, tablet sample solution, and urine sample solution, respectively. The recovery ratio for the proposed sensor ranged between 86.6 and 103.5%.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ2HASK-Net: new hybrid attention selective kernel network for automatic colon cancer detection from colonoscopy images
Imak, Andaç; Doğan, Gürkan; Sengur, Abdulkadir; Ergen, Burhan
Colorectal cancer is a frequently analyzed cancer type seen today. It is the third leading of cancer in terms of incidence. It is among the second leading cases resulting in death. However, when detecting pre-cancerous polyps using traditional methods, the rate of being overlooked is high. Therefore, the rate of missed polyps can be greatly reduced with deep learning-based computer-aided diagnosis (CADx) methods. In this study, a novel convolutional neural network based on CADx, called HASK-Net, is proposed for automatic polyp detection. While HASK-Net uses ResNet50 as a feature extractor in the encoder network, the novely designed hybrid attention selective kernel convolution uses it in the decoder network to increase the representation power in feature maps and learn more complex features. In experimental results on the publicly available Hiper-Kvasir and EndoTech 2020 benchmark datasets, HASK-Net showed extremely promising performance with a dice similarity score of 97.02% and 84.83% and an mIoU score of 95.38% and 84.32%, respectively.
- MakaleAçık Erişim2025Scopus SJRQ1Green Synthesis of Multi-Walled Carbon Nanotube-Reinforced Hydroxyapatite Doped with Silver and Silver-Core Selenium-Shell Nanoparticles: Synthesis, Characterization, and Biological Activity
Unal, İlkay
Hydroxyapatite (HAp) is widely used in biomedical applications due to its biocompatibility, osteoconductivity, and bioactivity. However, its low mechanical strength, tendency toward rapid corrosion, and lack of bactericidal properties present significant limitations in applications. This study aimed to improve the properties of HAp by reinforcing it with multi-walled carbon nanotubes (MWCNTs) and doping it with silver nanoparticles (AgNPs) and silver-core selenium-shell nanoparticles (Ag@SeNPs). Ocimum basilicum extract was used as both a reducing and stabilizing agent in the synthesis of nanoparticles using an environmentally friendly and non-toxic method as an alternative to traditional methods. The synthesized HAp, HAp/MWCNT, Ag-HAp/MWCNT, and Ag@Se-HAp/MWCNT nanocomposites were characterized by TEM, SEM, XRD, Raman spectroscopy, and BET analysis. BET analysis showed a reduction in surface area from 109.4 m2/g for pure HAp to 71.4 m2/g, 47.5 m2/g, and 35.3 m2/g for HAp/MWCNTs, Ag- HAp/MWCNTs, and Ag@Se-HAp/MWCNTs, respectively. Antimicrobial activities against P. aeruginosa, E. coli, S. aureus, E. faecalis, and C. albicans were evaluated. HAp and HAp/MWCNT did not show any antimicrobial activity, while Ag-HAp/MWCNTs showed inhibition zones of 14 mm for Escherichia coli and 18 mm for Pseudomonas aeruginosa at 5 mg/mL. Ag@Se-MWCNTs/HAp exhibited superior efficacy with inhibition zones of 18 mm, 12 mm, and 20 mm for S. aureus, E. faecalis, and Candida albicans, respectively. The incorporation of Ag@SeNPs enhanced HAp’s antibacterial and antifungal properties through a synergistic mechanism.
AtıfScopus12WoS10OpenAlex12İncele - MakaleAçık Erişim2025Scopus SJRQ1The effect of motivational interviewing on healthy lifestyle behaviors and quality of life in on menopausal women: a pilot randomized controlled trial
Orhan, İlksen; Yağmur, Yurdagül
Background: This study aims to determine the effect of motivational interviewing (MI), an effective communication technique, on healthy lifestyle behaviors and quality of life in menopausal women. Methods: This is a randomized controlled empirical study. The study was conducted with a total of 136 women, including 68 for experimental group and 68 for control group. The data were collected using an introductory information form, the Health Promoting Lifestyle Profile II (HPLPL II) and the Menopause-Specific Quality of Life (MENQOL). Women in the experimental group received 6 sessions of motivational interviewing and 2 follow-up interviews in two family health centers (FHCs) from the researcher. No intervention was applied to women in the control group. The data were analyzed using number, percentage, mean, standard deviation, chi-square test, Bonferroni test, independent samples t test and repeated ANOVA. Results: There was a statistically significant difference between the HPLPL II total scale and health responsibility, nutrition, spiritual development, interpersonal relationships, and stress management subscales pre-test, interim test and post-test mean scores of women in the experimental group, and their mean scores increased positively (p < 0.001). In addition, a statistically significant difference was also found between their MENQOL vasomotor, psychosocial, physical and sexual domains pre-test, mid-test and post-test mean scores (p < 0.05). Conclusion: Motivational interviewing was found to be effective in increasing healthy lifestyle behaviors and quality of life in menopausal women. Trial registration: Current Controlled Trials NCT06802458, 17/01/2025 (https//clinicaltrials.gov/study/NCT06802458), “Retrospectively registered”.
AtıfScopus3WoS3OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1ADAMTS-1, a multifunctional proteinase, in the uterus of both estrous cycle rats and ovariectomized rats can be regulated via hormones
Parlak Ak, Tuba; Yaman, Mine; Bayrakdar, Ali; Bulmus, Ozgur
Remodeling of the extracellular matrix (ECM) throughout the estrous cycle is one of the most striking features of the uterus. A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS-1) is a metalloproteinase responsible for the degradation of some proteoglycans, which are ECM components. In this study, ADAMTS-1 distribution was analyzed in the uterus of ovariectomized rats administered 17β-estradiol (E2) and progesterone (P4) and in the uterus at different estrous stages. Ovariectomized (OVX) rats were subjected to single and combined E2 (0.2 mg/kg) and P4 (10 mg/kg) hormone replacement therapies. E2 was administered for 3 consecutive days, followed by E2, P4, or E2 + P4 for 4 consecutive days. The serum level of E2 decreased from the proestrus phase to the diestrus phase, but that of P4 was the highest in the estrus phase. During the estrus phase, the serum level of luteinizing hormone (LH) was the lowest and that of follicle-stimulating hormone (FSH) was the highest. P4 level increased significantly in the OVX + P4 and OVX + E2 + P4 groups compared with the OVX group. The serum levels of LH and FSH decreased in the OVX + E2 and OVX + P4 groups compared with the OVX group, and were the lowest in the OVX + E2 + P4 group. ADAMTS-1 immunoreactivity in luminal, glandular, and stromal cells of the uterus decreased from proestrus to diestrus. When immunoreactivity in hormone replacement groups was compared, weak immunoreactivity was observed in the OVX group. ADAMTS-1 immunoreactivity gradually increased in OVX + P4 and OVX + E2 groups, and was particularly notable in luminal, glandular, and stromal cells in the OVX + E2 + P4 group. ADAMTS-1 distribution was affected by the estrous cycle process and hormone replacement therapy in the OVX procedure.
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