Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleYalnız künye2018Scopus SJRQ2Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage
Benzer, Fulya; Kandemir, Fatih Mehmet; Kucukler, Sefa; Comaklı, Selim; Caglayan, Cuneyt
Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However, nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate protective effects of curcumin (CMN) against DXR-induced nephrotoxicity. Rats were subjected to oral treatment of CMN (100 and 200 mg/kg body weight) for 7 days. Nephrotoxicity was induced by single intra peritoneal injection of DXR (40 mg/kg body weight) on the fifth day and then the experiment was terminated on the eighth day. Nephroprotective effects of CMN were associated with decrease in serum toxicity markers and increase in antioxidant enzyme activities. CMN was able to reduced the levels of inflammatory markers such as TNF-α, NF-κB, IL-1β, iNOS and COX-2 in the rats. It also reduced the expressions of apoptotic marker including caspase-3, and oxidative DNA damage marker including 8-OHdG. Collectively, these findings indicated that CMN protect against DXR-induced nephrotoxicity.
AtıfScopus116WoS111OpenAlex122
İncele - MakaleAçık Erişim2018Scopus SJRQ3A New Application Based on GPLVM, LMNN, and NCA for Early Detection of the Stomach Cancer
Korkmaz, Sevcan Aytaç; Esmeray, Furkan
In this article, speeded-up robust features (SURF) for each image have been calculated. Discrete Fourier transform (DFT) method has been applied to these SURF. High dimensions of these SURF–DFT feature vectors are reduced to low dimensions with large-margin nearest neighbor (LMNN), Gaussian process latent variable models (GPLVM), and neighborhood component analysis (NCA). When size reduction process was done, effect on the GPLVM, LMNN, and NCA of the 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 feature numbers has been examined. These features are classified by naive Bayes (NB) classifier. Thus, SURF_DFT_GPLVM_NB, SURF_DFT_NCA_NB, and SURF_DFT_LMNN_NB methods for gastric histopathological images have been developed. Classification results obtained with these methods have been compared. According to the obtained results, the highest classification result was obtained as 90.24% by using 4 features by SURF_DFT_GPLVM_NB method for second group images.
AtıfScopus5WoS4OpenAlex7İncele - MakaleAçık Erişim2018Heartbeat type classification with optimized feature vectors
Yıldırım, Özal; Baloglu, Ulas Baran
In this study, a feature vector optimization based method has been proposed for classification of the heartbeat types. Electrocardiogram (ECG) signals of five different heartbeat type were used for this aim. Firstly, wavelet transform (WT) method were applied on these ECG signals to generate all feature vectors. Optimizing these feature vectors is provided by performing particle swarm optimization (PSO), genetic search, best first, greedy stepwise and multi objective evoluationary algorithms on these vectors. These optimized feature vectors are later applied to the classifier inputs for performance evaluation. A comprehensive assessment was presented for the determination of optimized feature vectors for ECG signals and best-performing classifier for these optimized feature vectors was determined.
AtıfScopus7OpenAlex7
İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats; [Ratlarda bakır fazlalığına karşı yem tüketimi, antioksidan durum ve karaciğer ile böbrek dokularının histolojik parametreleri üzerine propolis ve fluniksin meglümin'in koruyucu etkileri]
Tatli Seven, Pınar; Gül Baykalir, Burcu; Parlak Ak, Tuba; Seven, İsmail; Başak, Neşe; Yaman, Mine
This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.
AtıfScopus10OpenAlex9İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of chrysin and flunixin meglumine against excess copper in male rats
Seven, Pinar Tatli; Baykalir, Burcu Gül; Seven, Ismail; Ak, Tuba Parlak; Başak, Neşe; Güllüoglu, Hakan
Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: Control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-α levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.
AtıfScopus8WoS7OpenAlex9TR Dizin2İncele - MakaleYalnız künye2018Scopus SJRQ3An efficient compression of ECG signals using deep convolutional autoencoders
Yildirim, Ozal; Tan, Ru San; Acharya, U. Rajendra
Background and objective: Advances in information technology have facilitated the retrieval and processing of biomedical data. Especially with wearable technologies and mobile platforms, we are able to follow our healthcare data, such as electrocardiograms (ECG), in real time. However, the hardware resources of these technologies are limited. For this reason, the optimal storage and safe transmission of the personal health data is critical. This study proposes a new deep convolutional autoencoder (CAE) model for compressing ECG signals. Methods: In this paper, a deep network structure of 27 layers consisting of encoder and decoder parts is designed. In the encoder section of this model, the signals are reduced to low-dimensional vectors; and in the decoder section, the signals are reconstructed. The deep learning approach provides the representations of the low and high levels of signals in the hidden layers of the model. Hence, the original signal can be reconstructed with minimal loss. Very different from traditional linear transformation methods, a deep compression approach implies that it can learn to use different ECG records automatically. Results: The performance was evaluated on an experimental data set comprising 4800 ECG fragments from 48 unique clinical patients. The compression rate (CR) of the proposed model was 32.25, and the average PRD value was 2.73%. These favourable observation suggest that our deep model can allow secure data transfer in a low-dimensional form to remote medical centers. We present an effective compression approach that can potentially be used in wearable devices, e-health applications, telemetry and Holter systems.
AtıfScopus201OpenAlex206İncele - Derleme MakaleYalnız künye2018Scopus SJRQ2A review of occupational health and safety risk assessment approaches based on multi-criteria decision-making methods and their fuzzy versions
Gul, Muhammet
Occupational health and safety (OHS) is a multidisciplinary activity working under the tasks of protection of workers and worksites. Risk assessment, as a compulsory process in implementation of OHS, stands out as evaluating the risks arising from the hazards, taking into account the required control measures, and deciding whether or not the risks can be reduced to an acceptable level. The diversity in risk assessment approaches is such that there are many methods for any industry. Multicriteria decision-making (MCDM)-based approaches contribute to risk assessment knowledge with their ability on solving real-world problems with multiple, conflicting, and incommensurate criteria. This article conducts a critical state-of-the-art review of OHS risk assessment studies using MCDM-based approaches. Additionally, it includes fuzzy versions of MCDM approaches applied to OHS risk assessment. A total of 80 papers are classified in eight different application areas. The papers are reviewed by the points of publication trend, published journal, risk parameters/factors, and tools used. This critical review provides an insight for researchers and practitioners on MCDM-based OHS risk assessment approaches in terms of showing current state and potential areas for attempts to be focused in the future.
AtıfScopus181WoS144OpenAlex189İncele - MakaleYalnız künye2018Scopus SJRQ3Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats
Benzer, Fulya; Kandemir, Fatih Mehmet; Ozkaraca, Mustafa; Kucukler, Sefa; Caglayan, Cuneyt
Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. The present study aimed to assess the ameliorative effect of curcumin against DXR-induced cardiotoxicity in rats. Rats were subjected to oral treatment of curcumin (100 and 200 mg/kg body weight) for 7 days. Cardiotoxicity was induced by single intraperitoneal injection of DXR (40 mg/kg body weight) on the 5th day and the rats sacrificed on 8th day. Curcumin ameliorated DXR-induced lipid peroxidation, glutathione depletion, decrease in antioxidant (superoxide dismutase, catalase, and glutathione peroxidase) enzyme activities, and cardiac toxicity markers (CK-MB, LDH, and cTn-I). Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-α, and interleukin-1β, and cardiac tissue damages that were induced by DXR. Moreover, curcumin decreased the expression of 8-OHdG and 3,3′-dityrosine. This study demonstrated that curcumin has a multi-cardioprotective effect due to its antioxidant, anti-inflammatory, and antiapoptotic properties.
AtıfScopus154WoS143OpenAlex163İncele - MakaleAçık Erişim2018Scopus SJRQ2Observations of crayfish plague infections in commercially important narrow-clawed crayfish populations in Turkey
Kokko, Harri; Harlioglu, Muzaffer M.; Aydin, Hamdi; Makkonen, Jenny; Gökmen, Gökhan; Aksu, Önder; Jussila, Japo
We studied the presence of possible Aphanomyces astaci infections in eight Turkish narrow-clawed crayfish (Astacus leptodactylus) populations by analyzing the prevalence and genotypes of the disease agent A. astaci. The qPCR analyses revealed A. astaci infection in seven of the studied eight populations, with the agent level A2 or higher. The agent levels among the infected populations varied from A0 to A5, i.e., from negative to high level of infection, based on qPCR ranking. Based on the sequencing of the chitinase gene and the mitochondrial ribosomal rnnS and rnnL subunits, we detected both A (As) and B (PsI) haplogroups of A. astaci in our samples, with each of the studied populations being carriers of only one haplotype. The results confirm previous detections of A. astaci in Turkish narrow-clawed crayfish populations and reveal, that both A and B haplogroup A. astaci carriers exist widely in A. leptodactylus populations of Turkey.
AtıfScopus28WoS29OpenAlex23İncele - MakaleYalnız künye2017Scopus SJRQ2Marine Fungi Against Aquaculture Pathogens and Induction of the Activity via Co-Culture
Özkaya, Ferhat Can; Peker, Zerife; Camas, Mustafa; Camas, Anil Sazak; Altunok, Muhammet
Ethyl acetate extracts from 70 strains of marine-derived fungi, isolated from sponges, were screened against four fish pathogenic bacteria. Sixteen of the fungal isolates exhibited antibacterial activity against at least one pathogen. All the strains showed antibacterial activity against Vagococcus salmoninarum. Three isolates showed strong inhibition against all test pathogens and they may therefore be remarkable as a broad-spectrum antimicrobial. Nine isolates showed antibacterial activity against Lactococcus garvieae, six were against Vibrio anguillarum, and four isolates inhibited the growth of Yersinia ruckeri. Co-culture of the fungus with the mix of the pathogen bacteria led to the induction of bioactivity in two isolates. Aspergillus iizukae produced strong and broad-spectrum antibacterial activity against pathogens with minimum inhibitory concentrations of 0.8-406 mu gmL(-1). The screening results confirmed the sponge associated fungi as a source of environmentally friendly antimicrobials that may contribute the sustainable development of aquaculture. In addition, co-culture technique is a promising strategy to increase antimicrobial activity that can stimulate the production of novel compounds, and increases the antimicrobial activities of marine derived fungi.
AtıfWoS5OpenAlex7İncele - MakaleYalnız künye2017Scopus SJRQ2Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2) Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines
Aydin, Ali; Korkmaz, Sengul Aslan; Demir, Veysel; Tekin, Saban
Background: In cancer, apoptosis relevant proteins-such as CaM kinase, Bcl-2 or P53, topoisomerase I, cell migration feature and DNA/BSA-macromolecules represent significant targets for current chemotherapeutics. Objective: We recently reported two coordination compounds-[Cu(C6H16N2O2)(2)][Ni(CN)(4)] (1) and [Cu(C6H16 N2O2) Pd(CN)(4)] (2)-together with their IR spectra, magnetic properties, thermal analyses and crystal structures. Herein, we describe the ability of these complexes to induce apoptosis in relevant proteins and stimulate topoisomerase I activity, cell migration velocity and DNA/BSA binding properties. Method: The in vitro antiproliferative effects and cell toxicity of both compounds were investigated through pharmacological measurement techniques, and interactions between both compounds and CT-DNA/BSA were studied with UV-Vis spectroscopy and fluorescence spectroscopy. Results & Conclusion: Studies on cells revealed that 2 (i) demonstrated a high antiproliferative effect, which was higher toward HeLa and C6 cancer cells than toward healthy Vero cells; (ii) impaired the migration of HeLa cells; (iii) altered the P53-Bcl-2 ratio in favor of apoptosis; (iv) strongly bound to DNA/BSA macromolecules; and (v) inhibited human topoisomerase I and KpnI or BamHI restriction endonucleases. In conclusion, this preliminary information demonstrates that 2 may represent a promising antiproliferative agent and a potential candidate for a therapeutic approach against HeLa.
AtıfWoS3OpenAlex4İncele - MakaleAçık Erişim2017Scopus SJRQ2Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus)
Kaya, Hasan; Duysak, Muge; Akbulut, Mehmet; Yilmaz, Sevdan; Guerkan, Mert; Arslan, Zikri; Demir, Veysel; Ates, Mehmet
Zinc nanoparticles (ZnNPs) are among the least investigated NPs and thus their toxicological effects are not known. In this study, tilapia (Oreochromis niloticus) were exposed to 1 and 10 mg/L suspensions of small size (SS, 40-60 nm) and large size (LS, 80-100 nm) ZnNPs for 14 days under semi-static conditions. Total Zn levels in the intestine, liver, kidney, gill, muscle tissue, and brain were measured. Blood serum glucose (GLU), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactate dehydrogenase (LDH) were examined to elucidate the physiological disturbances induced by ZnNPs. Organ pathologies were examined for the gills, liver, and kidney to identify injuries associated with exposure. Significant accumulation was observed in the order of intestine, liver, kidney, and gills. Zn levels exhibited time- and concentration-dependent increase in the organs. Accumulation in kidney was also dependent on particle size; NPs SS-ZnNPs were trapped more effectively than LS-ZnNPs. No significant accumulation occurred in the brain (p>0.05) while Zn levels in muscle tissue increased only marginally (p0.05). Significant disturbances were noted in serum GOT and LDH (p<0.05). The GPT levels fluctuated and were not statistically different from those of controls (p>0.05). Histopathological tubular deformations and mononuclear cell infiltrations were observed in kidney sections. In addition, an increase in melano-macrophage aggregation intensity was identified on the 7th day in treatments exposed to LS-ZnNPs. Mononuclear cell infiltrations were identified in liver sections for all treatments. Both ZnNPs caused basal hyperplasia in gill sections. Fusions appeared in the gills after the 7th day in fish treated with 10 mg/L suspensions of SS-ZnNPs. In addition, separations in the secondary lamella epithelia were observed. The results indicated that exposure to ZnNPs could lead to disturbances in blood biochemistry and cause histopathological injuries in the tissues of O. niloticus. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1213-1225, 2017.
AtıfWoS22OpenAlex28İncele - MakaleYalnız künye2017Scopus SJRQ2Occupational health and safety risk assessment in hospitals: A case study using two-stage fuzzy multi-criteria approach
Gul, Muhammet; Ak, M. Fatih; Guneri, Ali Fuat
Occupational Health and Safety (OHS) is a basis to reduce occupational accidents in an acceptable level, and it covers employee health, safety, and welfare in the workplaces. Hospitals as the largest employer group in healthcare industry in Turkey face major hazards categorized as chemical, biological, physical, ergonomic, and psychosocial risks. Although Turkey demonstrates rapid economic growth, OHS practices have not been fully put into practice, and necessary attention has not been paid to the health industry. For this reason, this paper aims to assess risks for health staff, contribute for planning of health services, and enhance regulations. A case study was carried out in a leading hospital in Turkey using a two-stage fuzzy multi-criteria approach, which provides more consistency in decision-making process and gives an appropriate final rank of hazard types. Fuzzy Analytic Hierarchy Process (FAHP) is used in weighing five risk parameters, which are severity, occurrence, undetectability, sensitivity to maintenance non-execution, and sensitivity to personal protective equipment (PPE) non-utilization. The fuzzy VIKOR (FVIKOR) approach is then applied for prioritization of hazard types in each department of the hospital. On conclusion of the hazard control hierarchy, measures are overtaken for the hazards, and areas open for improvement are presented.
AtıfWoS97OpenAlex125İncele - MakaleYalnız künye2017Scopus SJRQ1Examination of the Correlation Between Internet Addiction and Social Phobia in Adolescents
Yayan, Emriye Hilal; Arikan, Duygu; Saban, Fatma; Bas, Nazan Gurarslan; Özcan, Ozlem Ozel
This was a descriptive and cross-sectional study conducted with adolescents to examine the correlation between Internet addiction and social phobia. The population of the study consisted of 24,260 students aged between 11 and 15 years. Sampling method was used from population with known number, and 1,450 students were calculated as sample of the study. In this study, 13.7% of the adolescents had an Internet addiction, and 4.2% spent more than 5 hr on the computer every day. There was a positive correlation between Internet addiction and social phobia. The form of time spent on Internet was examined in terms of addiction and social phobia; although Internet addiction was related to games, dating sites, and web surfing, social phobia was related to homework, games, and web surfing. It was hypothesized that adolescents with social phobia were Internet addicts, and the participants used the Internet to spend time rather than socialize.
AtıfWoS25OpenAlex45İncele - MakaleAçık Erişim2017An Epidemiological Examination of Suicides That Have Occurred in Tunceli During 2005-2015
Günderci, Azad; Karatay, Gulnaz; Gökçe, Seher; Güler, Burcu
Objective: The study aims to investigate the phenomena in suicides and attempted suicides that have occurred in Tunceli during 2005-2015, with respect to certain characteristics. Method: The files for 435 suicides and attempted suicide incidents in total, which have been recorded in Tunceli during 2005-2015, have been examined in this paper. Results: The suicide incidents have been determined most frequently among individuals under 24 years of age. In the evaluation of the causes for suicide, unknown reasons (51.5%) have been followed by family problems (21.1%) and psychiatric disorders (18.2%). Drug intoxications, use of stabbing instruments and hanging methods have taken the top three ranks among the suicide methods. 91.3% of the incidents consisted of suicide attempts and 8.7% completed suicides. While the ratio of completed suicides has been determined to be meaningfully higher in males (7.1%), the ratio of attempted suicides has been determined to be higher in females (95.6%) (p<0.05). Furthermore, it has been determined that the suicide incidents were observed more frequently during the spring and summer seasons and more in urban zone. Conclusion: Our findings indicate that the causes of almost half of the suicide incidents in Tunceli are not known. The most important risk factors for suicide have been identified as young age, male gender, unemployment, urban life, impaired mental health and in-family problems. Further comprehensive studies are recommended as aimed to assess the suicide incidents in Tunceli and take protective measures for the risk factors.
AtıfWoS2OpenAlex6İncele - MakaleYalnız künye2017Scopus SJRQ1Evaluation of School of health students' ethics position in Turkey
Sen, Emine; Dal, Nursel Alp; Üstün, Cagatay; Okursoy, Algin
Background: The advances in science and technology increasingly lead to the appearance of ethical issues and to the complexity of care. Therefore, it is important to define the ethics position of students studying in health departments so that high quality patient care can be achieved. Objectives: The aim of this study was to examine the ethics position of the students at Shool of Health of an University in western Turkey. Methods: The study design was descriptive and cross-sectional. The study population included 540 first, second, third, and fourth year students from the Departments of Nursing, Midwifery, and Rescue and Disaster Management in the 2013-2014 academic year. Data were collected with a Personal Identification Form and The Ethics Position Questionnaire. Obtained data were analyzed with Chi-square test, Confirmatory Factor Analysis, and Nested Analysis of Variance. Ethical considerations: Before conducting the research, approval was obtained from Ege University Clinical Research Ethics Committee in Izmir and written informed consent was taken from all the participants. Findings: There was no significant difference in the mean scores for the Ethics Position Questionnaire between the students in terms of years and fields of study. Although the mean scores for the subscale idealism did not differ between fields of study, the mean scores significantly differed between years of study. However, the mean scores for the subscale relativism did not differ in terms of years and fields of study. Discussion: Whether students are idealistic or relativistic in terms of ethical judgment will be effective in ethical decision-making skills during patient care. Therefore, we need to define the factors that influence students' ethics position in the future. Conclusion: It is suggested that the courses and practices that teach students to be aware of their ethics position to create an ethical outlook can be placed in the curriculum in health schools.
AtıfWoS7OpenAlex9İncele - MakaleYalnız künye2017Scopus SJRQ2Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey)
Güneş, Suzan; Savran, Ahmet; Paksoy, Mehmet Yavuz; Koşar, Müberra; Çakılcıoğlu, Uğur
This study identifies wild plants collected for medical purposes by local people of Karaisalı County in the Mediterranean Region of Turkey, together with the uses and local names of these plants. A field study was carried out over a period of approximately 2 years (2008–2010). During this period, 129 vascular plant specimens were collected. Demographic characteristics of participants, local plant names, parts used and methods of preparation of the plants were investigated and recorded. Within the scope of the study, relevant plant species were collected; herbarium materials were prepared; and the specimens were labelled. In addition, the use-value of the species was determined and calculated for the medicinal plants included in the study. A total of 129 medical plants belonging to 59 families were identified in the region. The most common families were: Lamiaceae (14 plants), Asteraceae (11 plants), Rosaceae (10 plants), Apiaceae (5 plants), Euphorbiaceae (5 plants). A comparison of the data obtained in this study with experimental data obtained in previous laboratory studies, confirmed most of the ethnobotanical uses. The plant flora of Karaisalı is threatened by such factors as grazing, expansion of new agricultural lands, and unsustainable harvesting of plants to generate income. Steps should be taken immediately to ensure the inclusion of relevant flora within conservation designations.
AtıfScopus89WoS76OpenAlex95İncele - MakaleYalnız künye2017Scopus SJRQ1Biodegradation of hydroxyapatite coated Rex-734 alloy with silver and selenium/chitosan substitutions: In vitro analysis
Aksakal, B.; Say, Y.; Buyukpinar, Ç.; Bakirdere, S.
Hydroxyapatite (HA) based bioceramic coatings; such as single-HA, double layered with Silver-Ag, Selenium-Se and Chitosan substitutions on Rex-734 alloy were executed by using the sol-gel method. Surface morphologies and adhesion strengths of the obtained coatings were investigated and coating material weight losses and metal ion releases from the substrates were determined in SBF (Simulated Body Fluid) environment. The coatings were characterized by SEM, EDS, XRD and adhesion strengths between the substrate and bioceramic coatings were measured with adhesion tests. SEM analyses revealed that crack-free surface morphologies were obtained in all bioceramic coatings. The coatings were kept in SBF for immersion periods from one to four weeks and the weight loss (%) in coatings and changes in ion release rates were determined. HA/Ag double layered coatings applied on the Rex-734 alloy increased the adhesion strength and accordingly reduced the weight losses (%) of coating materials in SBF. Se/Chitosan double layered coatings were found to decrease the adhesion strength and increase the weight losses (%) in SBF. Additionally, all bioceramic coatings were observed to prevent the elemental ion release by physical barrier effect for the release of metal ions during the four weeks immersion period in SBF.
AtıfScopus12WoS11OpenAlex12İncele - MakaleYalnız künye2017Scopus SJRQ2The effect and characterization of newly synthesized SrBr2 reinforced bone grafts on structure and cell viability
Demirel, Mehtap; Aksakal, Bünyamin; Kaya, Ali İhsan
Abstract: In this study, a highly durable SrBr2 compound was added to Ca(NO3)2·4H2O, KOH, NaNO3, P2O5, and urea (CO(NH2)2) compounds at different ratios (wt 10–30%); biografts were synthesized in different compositions using the sol gel method They were characterized using X-ray diffraction, Fourier transform infrared spectrometer, scanning electron microscope, and mechanical tests e.g. hardness and compression. Structural, mechanical properties and cell viabilities of the synthesized biografts were comparatively examined. Fourier transform infrared spectrometer and X-ray diffraction analysis results showed that, including SrBr2, hydroxyapatite had formed in the biografts. Also, hardness and compression tests revealed that compressive stress and hardness values of the grafts increased as the amount of SrBr2 increased. The cell viability ratios also enhanced with the amount of SrBr2 increased in the synthesized biografts. Graphical Abstract: [InlineMediaObject not available: see fulltext.]
AtıfScopus2WoS2OpenAlex3İncele - Derleme MakaleYayıncıda açık erişim2017Scopus SJRQ3Regulation of signaling pathways by tanshinones in different cancers
Lin, X.; Qureshi, M.Z.; Romero, M.A.; Khalid, S.; Aras, A.; Ozbey, U.; Farooqi, A.A.
Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics. However, the insights gained from work in this natural product research have far-reaching impact because of rapidly increasing repertoire of medicinally and biologically efficient phytochemicals. How Tanshinones mediate targeting of JAK-STAT, ER stress associated signaling cascade,PI3K/AKT/mTOR pathway,autophagy, TRAIL pathway and microRNAs are being discovered and will prove to be helpful in getting a step closer to personalized medicine.
AtıfScopus12OpenAlex12İncele
